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Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology

ISBN: 978-3-527-31261-0
294 pages
February 2006
Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology (3527312617) cover image


This keenly awaited first overview of the field represents a complete guide to the structure and function of the most important mammalian cell membrane organelles. Filling a huge gap in the primary literature, this book is the first to cover the subject in detail.
Following an introduction by Kai Simons, the discoverer of lipid rafts and the most prominent scientist in the field, chapters include:
Historical background
Distinct structures and functions
Structural basis
Viral entry and virion budding
Cholesterol transport
Lipid shells
Cell polarity and intracellular trafficking
Cancer cells
Of prime importance to molecular and cell biologists, biochemists, membrane scientists, cancer researchers, and virologists.
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Table of Contents

Lipid Rafts, Caveolae, and Membrane Traffic
The Forces that Shape Caveolae
The Biophysical Characterization of Lipid Rafts
The Role of Caveolae and Noncaveolar Rafts in Endocytosis
Role of Cholesterol in Signal Transduction from Caveolae
Phosphorylation of Caveolin and Signaling from Caveolae
Role of Lipid Microdomains in the Formation of Supramolecular Protein Complexes and Transmembrane Signaling
Caveolin and its Role in Intracellular Chaperone Complexes
The Roles of Caveolae and Caveolin in Cell Shape, Locomotion, and Stress Fiber Formation
Lipid Rafts in Trafficking and Processing of Prion Protein and Amyloid Precursor Protein
Caveolae and the Endothelial Nitric Oxide Synthase
The Role of Caveolin-1 in Tumor Cell Survival and Cancer Progression
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Author Information

Christopher Fielding is Neider Professor of Cardiovascular Physiology at the University of California at San Francisco (UCSF). He graduated from University College in London (UK) where he also received his PhD. After appointments at Oxford University and at the University of Chicago, he joined the faculty at UCSF in 1971, being appointed full professor in 1985.
Professor Fielding's main research interest is in the trafficking of cholesterol, its regulation and its role in signal transduction.
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"... well written and useful chapters."
Natural Cell Biology

"This is a book that will be useful to everyone interested in membrane biophysics. The chapters highlight the many unanswered questions in the field and detail some work that should be done in the future. Perhaps this book will stimulate more of us to get involved in the development of novel experimental methods and to continue trying to answer the critical unanswered questions." ChemBioChem

"... a timely summary of our current picture of the raft concept ... clarifies some misunderstood ideas."
Future Medicine

"In conclusion, this book is a delightful mix of structural biology, biophysics, cell biology, biochemistry, physiology and medicine. All researchers in biomedicine with an interest in membrane biology will find this book both informative and an excellent point of reference. Its acquisition would provide a valuable addition to the bookshelves of all who purchase it."
BSCB Newsletter
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Lipid Rafts and Caveolae: From Membrane Biophysics to Cell Biology (US $245.00)

-and- Student Companion to Accompany Fundamentals of Biochemistry, 4th Edition (US $102.95)

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