List of Contributors.

1 The Physics and Modeling of Biofunctionalized Nanoelectromechanical Systems (Mark R. Paul and Jerry E. Solomon).

1.1 Introduction.

1.2 The Stochastic Dynamics of Micro- and Nanoscale Oscillators in Fluid.

1.3 The Physics Describing the Kinetics of Target Analyte Capture on the Oscillator.

1.4 Detecting Noise in Noise: Signal-processing Challenges.

1.5 Concluding Remarks.

Acknowledgments.

References.

2 Mathematical and Computational Modeling: Towards the Development and Application of Nanodevices for Drug Delivery (John P. Sinek, Hermann B. Frieboes, Balakrishnan Sivaraman, Sandeep Sanga, and Vittorio Cristini).

2.1 Introduction.

2.2 RES Avoidance.

2.3 Tumoral Vasculature and Hemodynamics.

2.4 Receptor–Ligand-mediated Binding.

2.5 Intratumoral and Cellular Drug Kinetics and Pharmacodynamics.

2.6 Conclusion.

References.

3 Nanolithography: Towards Fabrication of Nanodevices for Life Sciences (Johnpeter Ndiangui Ngunjiri, Jie-Ren Li, and Jayne Carol Garno).

3.1 Introduction: Engineering Surfaces at the Nanoscale.

3.2 Immobilization of Biomolecules for Surface Assays.

3.3 Methods for Nanolithography with Proteins.

3.4 Detection of Protein Binding at the Nanoscale.

3.5 Future Directions.

References.

4 Microcantilever-based Nanodevices in the Life Sciences (Horacio D. Espinosa, Keun-Ho Kim, and Nicolaie Moldovan).

4.1 Introduction.

4.2 Microcantilevers.

4.3 Cantilevers with Integrated Micro- and Nano.uidics.

4.4 Applications.

4.5 Conclusions and Outlook.

References.

5 Nanobioelectronics (Ross Rinaldi and Giuseppe Maruccio).

5.1 Introduction.

5.2 Bio-self-assembly and Motivation.

5.3 Fundamentals of the Bio-building Blocks.

5.4 Interconnection, Self-assembly and Device Implementation.

5.5 Devices Based on DNA and DNA Bases.

5.6 Devices Based on Proteins.

5.7 Conclusions.

Acknowledgments.

References.

6 DNA Nanodevices: Prototypes and Applications (Friedrich C. Simmel).

6.1 Introduction.

6.2 DNA as a Material for Nanotechnology.

6.3 Simple DNA Devices.

6.4 Towards Functional Devices.

6.5 Autonomous Behavior.

6.6 Conclusion.

Acknowledgments.

References.

7 Towards the Realization of Nanobiosensors Based on G-protein-coupled Receptors (Cecilia Pennetta, Vladimir Akimov, Eleonora Al.nito, Lino Reggiani, Tatiana Gorojankina, Jasmina Minic, Edith Pajot-Augy, Marie-Annick Persuy, Roland Salesse, Ignacio Casuso, Abdelhamid Errachid, Gabriel Gomila, Oscar Ruiz, Josep Samitier, Yanxia Hou, Nicole Ja.rezic, Giorgio Ferrari, Laura Fumagalli, and Marco Sampietro).

7.1 Introduction.

7.2 Preparation and Immobilization of GPCRs on Functionalized Surfaces.

7.3 Signal Techniques.

7.4 Theoretical Approach.

7.5 The Impedance Network Model.

7.6 Equilibrium Fluctuations.

7.7 Conclusions.

Acknowledgments.

References.

8 Protein-based Nanotechnology: Kinesin–Microtubule-driven Systems for Bioanalytical Applications (William O. Hancock).

8.1 Introduction.

8.2 Kinesin and Microtubule Cell Biology and Biophysics.

8.3 Theoretical Transport Issues for Device Integration.

8.4 Interaction of Motor Proteins and Filaments with Synthetic Surfaces.

8.5 Controlling the Direction and Distance of Microscale Transport.

8.6 Cargo Attachment.

8.7 System Design Consideration.

8.8 Conclusion.

Acknowledgments.

References.

9 Self-assembly and Bio-directed Approaches for Carbon Nanotubes: Towards Device Fabrication (Arianna Filoramo).

9.1 Introduction.

9.2 CNTs: Basic Features, Synthesis and Device Applications.

9.3 Fabrication of CNT Transistors and Self-assembly Approaches.

9.4 In situ CVD Growth.

9.5 Selective Deposition of CNTs by SAM-assisted Techniques.

9.6 DNA-directed Self-assembly.

9.7 Conclusion.

References.

10 Nanodevices for Biosensing: Design, Fabrication and Applications (Laura M. Lechuga, Kirill Zinoviev, Laura G. Carrascosa, and Miguel Moreno).

10.1 Introduction.

10.2 From Biosensor to Nanobiosensor Devices.

10.3 Nanophotonic Biosensors.

10.4 Nanomechanical Biosensors.

10.5 Conclusions and Future Goals.

Acknowledgments.

References.

11 Fullerene-based Devices for Biological Applications (Ginka H. Sarova, Tatiana Da Ros, and Dirk M. Guldi).

11.1 Introduction.

11.2 Solubility.

11.3 Toxicity.

11.4 DNA Photocleavage.

Acknowledgments.

References.

12 Nanotechnology for Biomedical Devices (Lars Montelius).

12.1 Introduction.

12.2 Nanotechnologies.

12.3 Applications.

12.4 Discussion and Outlook.

Acknowledgments.

References.

13 Nanodevices in Nature (Alexander G. Volkov and Courtney L. Brown).

13.1 Introduction.

13.2 Multielectron Processes in Bioelectrochemical Nanoreactors.

13.3 Cytochrome Oxidase: A Nanodevice for Respiration.

13.4 Photosynthetic Electrochemical Nanoreactors, Nanorecti.ers, Nanoswitches and Biologically Closed Electrically Circuits.

13.5 Phototropic Nanodevices in Green Plants: Sensing the Direction of Light.

13.6 Membrane Transport and Ion Channels.

13.7 Molecular Motors.

13.8 Nanodevices for Electroreception and Electric Organ Discharges.

13.9 Neurons.

References.

Index.