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Asymmetric Synthesis with Chemical and Biological Methods

Dieter Enders (Editor), Karl-Erich Jaeger (Editor), Günter Helmchen (Foreword by)
ISBN: 978-3-527-31473-7
470 pages
April 2007
Asymmetric Synthesis with Chemical and Biological Methods (3527314733) cover image


Edited by two of the leading researchers in the field, this book provides a deep, interdisciplinary insight into stoichiometric and catalytic reactions in this continuously expanding area. A plethora of top German scientists with an international reputation covers various aspects, from classical organic chemistry to process development, and from the theoretical background to biological methods using enzymes. Throughout the focus is on the development of new synthetic methods in asymmetric synthesis, the synthesis of natural and bioactive compounds and the latest developments in both chemical and biological methods of catalysis, as well as the investigation of special technical and biotechnical aspects.
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Table of Contents

Development of Novel Enantioselective Synthetic Methods
Asymmetric Synthesis of Natural Products Employing the SAMP/RAMP-Hydrazone Methodology
Asymmetric Synthesis Based on Sulfonimidoyl-Substituted Allyltitanium Complexes
The "Daniphos" Ligands: Synthesis and Catalytic Applications
New Chiral Ligands Based on Substituted Heterometallocenes

Sulfoximines as Ligands in Asymmetric Metal Catalysis
Catalyzed Asymmetric Aryl Transfer Reactions
Substituted [2.2]-Paracyclophane Derivatives as Efficient Ligands for Asymmetric 1,2- and 1,4-Addition Reactions
Palladium-Catalyzed Allylic Alkylation of Sulfur and Oxygen Nucleophiles -
Asymmetric Synthesis, Kinetic Resolution and Dynamic Kinetic Resolution
The QUINAPHOS Ligand Family and its Application in Asymmetric Synthesis
Immobilization of Transition Metal Complexes and their Application to Enantioselective Catalysis

Directed Evolution to Increase the Substrate Range of Benzoylformate Decarboxylase from Pseudomonas Putida
C-C Bonding Microbial Enzymes: Thiamine Diphosphate-Dependent Enzymes and Class I Aldolases
Enzymes for Carboligation -
2-Ketoacid Decarboxylases and Hydroxynitrile Lyases
Preparative Syntheses of Chiral Alcohols using (R)-specific Alcohol Dehydrogenases from Lactobacillus strains
Biocatalytic C-C Bond Formation in Asymmetric Synthesis
Exploring and Broadening the Biocatalytic Properties of Recombinant Sucrose Synthase 1 for the Synthesis of Sucrose Analogues
Flexible Asymmetric Redox Reactions and C-C Bond Formation by Bioorganic Synthetic Strategies

Reaction Engineering in Asymmetric Synthesis
Biocatalyzed Asymmetric Syntheses Using Gel-Stabilized Aqueous-Organic Two-Phase Systems
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Author Information

Dieter Enders completed his PhD at the Justus-Liebig-Universität Giessen under the supervision of D. Seebach. After postdoctoral studies at Harvard University with E. J. Corey, he returned to Giessen and completed his habilitation. He became Associate Professor at the Universität Bonn in 1980, and moved to his present position as Professor of Organic Chemistry at the RWTH Aachen in 1985. He has received many awards (Leibniz-Prize of the DFG, Emil Fischer Medal of the GDCh, Yamada Prize, Japan) for his research, which focuses on the asymmetric synthesis of biologically active compounds and the development of new synthetic methods.

Karl-Erich Jaeger was born in Dortmund and studied biology and chemistry at the Ruhr-University Bochum, where he received his PhD under the supervision of U. Winkler. After postdoctoral studies with Robert E.W. Hancock at the Department of Microbiology of the University of British Columbia in Vancouver, he received his habilitation in Bochum in 1995. Karl-Erich Jaeger is currently Professor at the Heinrich-Heine University of Düsseldorf and Director of the Institute of Molecular Enzyme Technology at the Research Centre Jülich. His research interests include the expression, folding and secretion of bacterial enzymes, their optimization by directed evolution, and enantioselective biocatalysis.
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Reasonable contribution to the literature and indeed is a fantastic testimony to SFB 280 and its many talent participants. (Journal of the American Chemical Society, July 9, 2008)
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