Preface.

Part I Basic Aspects.

1 Some Introductory Concepts in Tumor Biology: Clonal Evolution and Autonomy versus Non-autonomy of Cancer Cells.

2 The Cell’s Life and Death: Cell Cycle, Senescence and Apoptosis.

Part II Genes Involved in Carcinogenesis.

3 Oncogenes.

4 Tumor-suppressor Genes.

5 Genomic Instability.

6 ATwist in the (Genetic) Tail: Cancer Epigenetics.

7 Nonautonomous Interactions in Carcinogenesis: Role of the Tumor Stroma.

8 Telomerase and Cellular Immortality.

9 Tumor Angiogenesis.

10 Metastasis.

Part III Specific Topics.

11 Tissue Context as a Determinant of the Tumor-suppressive or Oncogenic Function of Certain Genes.

12 Cancer Stem Cells.

13 Determination of Therapeutic Efficacy – Pharmacogenomics.

14 Certain Chemicals Induce Cancer: Chemical Carcinogenesis.

15 Hormones and Cancer.

16 Viral Oncogenesis.

Part IV Unifying the Concepts.

17 Cooperation of Multiple Biological Processes is Needed for the Development of Fully Fledged Malignancy.

18 Carcinogenesis In Vivo: Animal Models and Basic Approaches to Generate Genetically Modified Animals.

19 Multistage Carcinogenesis in Humans: Molecular Epidemiology and the Colon Cancer Model.

Part V Future Perspectives.

20 Epilogue.

Index.