This comprehensive overview of the whole field of fatigue and fracture of metallic materials covers both the theoretical background and some of the latest experimental techniques. It provides a summary of the complex interactions between material microstructure and cracks, classifying them with respect to the overall damage process with a focus on microstructurally short cracks and dynamic embrittlement. It furthermore introduces new concepts for the numerical treatment of fatigue microcrack propagation and their implementation in fatigue-life prediction models.This comprehensive overview of the whole field of fatigue and fracture of metallic materials covers both the theoretical background and the latest experimental techniques. It provides a summary of the complex interactions between material microstructure and cracks, classifying them with respect to the overall damage process. It furthermore introduces new concepts for the numerical treatment of fatigue microcrack propagation and their implementation in fatigue-life prediction models.