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Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology

ISBN: 978-3-527-31707-3
249 pages
March 2008, Wiley-Blackwell
Neural Degeneration and Repair: Gene Expression Profiling, Proteomics and Systems Biology (3527317074) cover image
With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases.
Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.
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1. INTRODUCTION
Microarrays in Translational Neuroscience - from Laboratory to Clinical Applications

2. REACTIONS OF PERIPHERAL NERVE TO TRAUMATIC INJURY AND AXON REGENERATION
The Potential of Genomewide Expression Profiling in Models of Peripheral Nervous System Injury and Repair

Largescale Screening for Regeneration-Associated Neural Proteins and Genes

Patterns of Genetic Regulation and Target Remodelling in Response to Molecular Signals to Neurons

Microarray Analysis to Decipher Peripheral Nerve Myelination

Unravelling the Mechanism of Neuropathic Pain using cDNA Arrays

Comparison of Axotomy-induced Neuronal Gene Expression Profiles in Regenerating Peripheral Nerve and Non-regenerating CNS Fiber Tract

3. CENTRAL NERVOUS SYSTEM TRAUMA AND NEURODEGENERATION
Single Cell Gene Expression and cDNA Microarray Analysis to Study Molecular Events in TBI, Neurological Degeneration and Restoration

Gene Expression Changes Induced by Blocking or Ablation of Nogo A in Spinal Cord Injury and Brain

Microarray Hybridization to Search for Genes Involved in Inhibition and Promotion of Spinal Cord Regeneration

Proteomics Technology Applied to Traumatic Brain Injury: Implications for the Identification of Diagnostic Predictors and New Therapeutic Targets

Molecular Changes in Neurodegenerative Disorders and Oxidative Stress Responses in Brain Injury

Proteomics in Molecular Medicine: Applications to CNS Diseases


4. GLYCOMIC TECHNOLOGIES APPLIED TO NERVOUS SYSTEM FUNCTION

Glycomic Approaches to Analyze Neural Functions of Glacosaminoglycans and Proteoglycans

Glycoproteomics and Glycan Profiling: Implications for Nervous System Function and Repair

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Hans Werner Müller has been Professor of Molecular Neurobiology at Düsseldorf University since 1993. From 2001 onwards he has acted as the founder of the Neuraxo Biotec GmbH company, where he is also Chairman of the board of directors. He has published more than 150 scientific articles in the field of neurobiology and neuroscience and is an active member of many scientific societies including the American Society for Neurosciences, and the German Society for Neuroscience, where he is chairman of the molecular neurobiology section.
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