"The overall quality of the book is high and it will be an important resource to the modified nucleoside community. The book contains a number of excellent individual chapters that offer a new and interesting perspective on the field … I believe that this book will be an excellent resource for synthesis chemists looking for summaries of existing strategies to generate a wide range of modified nucleosides. Along that line, the more clinically based chapters provide good summaries of the biological activities of the modified nucleotides. There is a nice balance of older and newer literature that should be of use to established as well as novice researchers, and most of the chapters are well referenced and up-to-date. I would certainly recommend this book to anyone interested in the bioorganic and medicinal chemistry of modified nucleosides and nucleic acids." (Journal of the American Chemical Society, March 25, 2009)

"Herdewijn, with the help of the contributing authors, has assembled a fine collection of well-written and well-edited reviews. This book will be indispensable to students and researchers." (ChemBioChem, January 2009)