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Chemoprevention of Cancer and DNA Damage by Dietary Factors

ISBN: 978-3-527-32058-5
838 pages
April 2009, Wiley-Blackwell
Chemoprevention of Cancer and DNA Damage by Dietary Factors (352732058X) cover image
This reference work provides a comprehensive overview of the field of dietary chemoprevention of cancer. It reviews the wide variety of dietary factors and mechanisms of anticarcinogenesis and antimutagenesis that have been identified in vitro and in animal and human studies. This volume covers the most recent molecular mechanism by which dietary antimutagens and anticarcinogens function, and also notes the needs for further research in this potentially important area of public health. It is a must-have reference for nutritional scientists, medicinal chemists, food scientists, biotechnologists, pharmacists, and molecular biologists working in academia or the pharmaceutical and food industries, as well as governmental and regulatory agencies concerned with nutrition and cancer. 

With a foreword by Bruce N. Ames.

Sections of the book:

● General Principles

● Experimental Models and Methods Used in Chemoprevention

● Selected Chemoprotective Dietary Factors and Components

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GENERAL PRINCIPLES
Molecular Mechanisms of Cancer Induction and Chemoprevention (Bartsch and Gerhäuser)
Types and Consequences of DNA Damage (Shaughnessy and DeMarini)
Induction of DNA Damage and Cancer by Dietary Factors (Parzefall, Kager and Knasmüller)
Mechanisms of Chemoprevention, Antimutagenesis, and
Anticarcinogenesis: An Overview (De Flora, Bennicelli, Battistella and Bagnasco)
Antioxidants and Cancer: Fact and Fiction (Collins and Favier)
Xenobiotic Metabolism: A Target for Nutritional Chemoprevention of Cancer? (Hansruedi Glatt)
Dietary Factors Regulate Metabolism of Carcinogens through Transcriptional Signaling Pathways (Shin and Kensler)
Endocrine-Related Cancers and Phytochemicals (Huber and Ott)
Inflammation-Induced Carcinogenesis and Chemoprevention (Ohshima, Tomono, Lai and Miyoshi)
DNA Methylation (Johnson, Belshaw and Elliott)
Prevention of Angiogenesis and Metastasis (Bhat,Mittal and Singh)
Impact of Dietary Factors on the Immune System (Meyer)
Epidemiological Studies (Miller)

EXPERIMENTAL MODELS AND METHODS USED IN CHEMOPREVENTION STUDIES
Methods Used for the Detection of Antimutagens: An Overview (Nersesyan, Misík and Knasmüller)
Methods to Determine Total Antioxidative Capacity and Oxidative DNA Damage (Wagner, Misík, Nersesyan and Knasmüller)
Measurement of Enzymes of Xenobiotic Metabolism in Chemoprevention Research (Huber and Grusch)
Methods for the Analysis of DNA Methylation (Rand and Molloy)
Methods Used to Study Alterations of Cell Signaling and Proliferation (Gerhäuser)
Methods for the Assessment of Antiangiogenic Activity (Gerhäuser)
Nutrigenomics (Frank and Rimbach)
Preneoplastic Models and Carcinogenicity Studies with Rodents (Ehrlich and Knasmüller)
The Role of Nutrition in the Etiology of Human Cancer: Methodological Considerations Concerning Epidemiological Studies (Boeing)

SELECTED CHEMOPROTECTIVE DIETARY FACTORS AND COMPONENTS
Carotenoids and Vitamin A (Polidori and Stahl)
Selected Vitamins
Folate and Vitamins (Thomas and Fenech)
Micronutrients and Susceptibility to Cancer: Focus on Selenium and Zinc (Ford and Hesketh)
DNA Damage and Cancer Chemoprevention by Polyphenols (Kunnumakkara, Anand, Harikumar and Aggarwal)
Antioxidant, Anti-inflammatory, and Anticarcinogenic Effects of Ginger and Its Ingredients (Na, Kundu and Surh)
Tannins: Bioavailability and Mechanisms of Action (Saura-Calixto and Pérez-Jiménez)
Selected Flavonoids
Phytoestrogens
Chemopreventive Properties of Coffee and Its Constituents (Faustmann, Cavin, Nersesyan, and Knasmüller)
Tea and Its Constituents
Protective Effects of Alcoholic Beverages and their Constituent
Sulfides in Allium Vegetables
Glucosinolates and Cruciferous Vegetables (Boyd, Gill, Borkowski, and Rowland)
Chlorophyll (Hayatsu, Negishi, and Arimoto-Kobayashi)
Dietary Fibers (Harris and Ferguson)
Dietary Fiber Carbohydrates and their Fermentation Products (Ferguson and Harris)
Lactobacilli and Fermented Foods (Fuchs, Stidl, Koller, Sontag, Nersesyan and Knasmüller)
Fatty Acids and Cancer Prevention (Lund)
Protease Inhibitors (Kennedy)

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Siegfried Knasmüller is head of the Chemoprevention Group at the Institute of Cancer Research. Having obtained his academic degrees from the Vienna University he continued his studies in the fields of genetic toxicology and cancer research at the University of Leiden, Case Western Reserve University, at US EPA in North Carolina and at the Institute of Experimental Cancer Research in Innsbruck before taking up his present appointment at the Medical University of Vienna. Prof. Knasmüller authored over 160 scientific publications and organized several international conferences on cancer chemoprevention and antimutagenesis and is member of the editoral board of a number of scientific journals such as Mutation Research, Mutagenesis and Food and Chemical Toxicology.
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