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The Sugar Code: Fundamentals of Glycosciences

ISBN: 978-3-527-32089-9
597 pages
October 2009, Wiley-Blackwell
The Sugar Code: Fundamentals of Glycosciences (352732089X) cover image

Description

A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy.
Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
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Table of Contents

CHEMICAL BASIS
The Biochemical Basis and Coding Capacity of the Sugar Code (Rüdiger, Gabius)
Three-dimensional Aspects of the Sugar Code (Kozár, André, Ulicny, Gabius)
The Chemist's Way to Synthesize Glycosides (Oscarson)
The Chemist's Way to Prepare Multivalency (Chabre, Roy)
Analytical Aspects: The Analysis of Protein-Bound Glycans (Nakagawa)
NATURAL GLYCOSYLATION -
GLYCOPROTEINS
N-Glycosylation (Zuber, Roth)
O-Glycosylation: Structural Diversity and Functions (Patsos, Corfield)
Glycosylation of Model and "Lower" Organisms (Wilson, Paschinger, Rendic)
Glycosylphosphatidylinositol Anchors: Structure, Biosynthesis and Functions (Shams-Eldin, Debierre-Grockiego, Schwarz)
NATURAL GLYCOSYLATION -
GLYCOLIPIDS, PROTEOGLYCANS, CHITIN
Glycolipids (Kopitz)
Proteoglycans (Buddecke)
Chitin (Merzendorfer)
PROTEIN-CARBOHYDRATE INTERACTIONS
Protein-Carbohydrate Interactions: Basic Concepts and Methods for Analysis (Solís, Romero, Menéndez, Jiménez-Barbero)
How to Determine Specificity: From Lectin Profiling to Glycan Mapping and Arrays (Tateno, Kuno, Hirabayashi)
The History of Lectinology (Rüdiger, Gabius)
Ca2+: Mastermind and Active Player for Lectin Activity (Including a Gallery of Lectin Folds) (Gabius)
Bacterial and Viral Lectins (Holgersson, Gustafsson, Gaunitz)
Plant Lectins (Rüdiger, Gabius)
Animal and Human Lectins (Gabius)
Routes in Lectin Evolution: Case Study on the C-Type Lectin-Like Domains (Gready, Zelensky)
Carbohydrate-Carbohydrate Interactions (Bucior, Burger, Fernŕndez-Busquets)
BIOMEDICAL ASPECTS AND CASE STUDIES
Diseases of Glycosylation (Hennet)
Animal Models to Delineate Glycan Functionality (Honke, Taniguchi)
Glycobiology of Fertilization and Early Embryonic Development (Habermann, Sinowatz)
Glycans as Functional Markers in Malignancy? (André, Kopitz, Kaltner, Villalobo, Gabius)
Small is Beautiful: Mini-Lectins in Host Defense (Lehrer)
Inflammation and Glycosciences (Schwartz-Albiez)
Sugars as Pharmaceuticals (Osborn, Turkson)
Platelet Glycoproteins as Lectins in Hematology (Hoffmeister, Falet)
Neurobiology meets Glycosciences (Ledeen, Wu)

COMPANION WEB-SITE: www.wiley-vch.de/home/thesugarcode
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Author Information

Hans-Joachim Gabius obtained his Ph.D. in 1982 at the Max-Planck-Institute for Experimental Medicine in Göttingen. After doing post-doctoral research from 1984-1985 in the group of S. H. Barondes at the UC San Diego, he was appointed first as assistant professor for biochemistry at the Max-Planck-Institute for Experimental Medicine in Göttingen (1987) and then as associate professor for pharmaceutical chemistry at the University of Marburg (1991). Since 1993 he is heading the Institute for Physiological Chemistry, Faculty of Veterinary Medicine at the University of Munich. Prof. Gabius received numerous research awards including the Otto-Hahn-Medal (1983), the Award of the Dr. Carl-Duisberg-Foundation (1988) and the Award of the Paul-Martini-Foundation (1990). His research interests are focused on chemical, biophysical and biochemical analysis of protein - carbohydrate interactions with biomedical relevance, such as the development of glycoscientific strategies for tumor diagnosis and therapy and the elucidation of functions of mammalian lectins. His research led to a prominent placement in the ISI ranking of highly cited papers in 1998.
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Reviews

“In summary, this ambitious book is a must-have for every library collection on carbohydrates and a great resource for chemistry and biology students curious for an entry into the rapidly growing area of glycosciences. The decoding process has just begun.” (ChemBioChem, 2010)
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Related Websites / Extra

Companion Website Click here to find files for lectures and tutorials. All figures (incl. legends) are presented in an easy to use, student-friendly format.
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Press Release

December 04, 2009
Decipher the Building Blocks of Life with ‘The Sugar Code’

The view that glycans are more complex and difficult to study than proteins and nucleic acids is no longer true. ‘The Sugar Code’ teaches us they are sweet and easy.”

Rocco Ungaro – University of Parma, Italy.

Glycans are one of the three major classes of biological macromolecules which encode the information essential for life, yet because of their complex structure and their diversity of functions glycosciences have been widely neglected in university courses. In this pioneering new textbook, The Sugar Code: Fundamentals of Glycosciences, editor Hans-Joachim Gabius and his team offer an engaging introduction to ‘the third alphabet of life’.

The book is strategically structured to deliver the best possible introduction to glycosciences guiding from the basics of the sugar alphabet and pertinent aspects of chemical/natural glycosylation to functional carbohydrate recognition (sugar code), with an eye on emerging medical relevance.

This title offers a uniquely multinational approach by bringing together a team of contributors from the forefront of science to cover the significant topics of the field, each explained in an engaging and thought provoking style with frequent cross-references to ensure a coherent overview. This structure makes the title ideal for designing a lecture series or as a stand-alone guide for independent study.

Glycobiology is a rapidly growing field that affects every known biological organism from fungi and plants to vertebrates, invertebrates and infectious viruses and bacteria. This diversity is reflected in the inter-disciplinary nature of the text, drawing together experts from across the scientific spectrum, from chemistry and biochemistry/cell biology to pharmacy and molecular medicine.

The chapters are consistently structured around the sugar code concept, revealing the molecular relations between different biological phenomenon. Each chapter shares the same interdisciplinary approach making the information readily digestible, with story-telling info boxes adding an entertaining touch.

Early chapters focus on the chemical basis of the sugar code and the process of glycosylation, the complex and biologically unique glycan assembly process.  The emphasis is then placed on the diverse biological functions that glycans perform, the interactions between molecules and the relation to diseases with implications for new routes of drug design

This engaging title not only serves as an accessible introduction to the fundamentals of Glycosciences, but is also a valuable resource for researchers across the scientific spectrum, with specific relevance for different specialities in chemistry, such as organic, physical, computational, inorganic, as well as the disciplines of cell biology, pharmacy, molecular biology, biomedicine and clinical disciplines such as medical microbiology or hematology.

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