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Modern Biophysical Chemistry

ISBN: 978-3-527-32360-9
310 pages
March 2009
Modern Biophysical Chemistry (3527323600) cover image
The only introductory text to address contemporary methods, the really interesting stuff to spice up a standard biophysics course is to be found here. Accessible and didactically written, it is based on a graduate course taught by the author for several years. By presenting a mix of basic theory and real life application examples, he successfully bridges the gap between theory and experiment.
Divided into two major parts, this advanced textbook explains all relevant methods used in current industrial research. The first part, basic biophysical chemistry, surveys basic spectroscopic techniques and properties that are the prerequisite for the more sophisticated technologies discussed in the remainder of the book. The second part covers modern, cutting-edge bioanalytical techniques based on physical methods, such as confocal fluorescence, ultrafast spectroscopy, optical tweezers, single molecule electrical measurements, quantum dots, and single molecule force microscopy. Equally, any student contemplating a career in the chemical, pharmaceutical or bio-industry will greatly benefit from the technological knowledge presented.
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Introduction: What is Biophysical Chemistry?

Basic Optical Principles
Optical Properties of Biomolecules
Basic Fluorescence Techniques
Chiroptical and Scattering Methods
Magnetic resonance techniques
Mass spectrometry

Fluorescence Microscopy
Super-Resolution Fluorescence Microscopy
Ultrafast and Nonlinear Spectroscopy
DNA Sequencing and Next Generation Sequencing Methods
Assay Development, Readers and High-Throughput Screening

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Peter J. Walla is a group leader at the Max-Planck-Institute for Biophysical Chemistry in Göttingen (Germany), and Professor for Biophysical Chemistry at the University of Braunschweig. Having obtained his academic degrees from the Universities of Heidelberg and Göttingen, Professor Walla did postdoctoral research at the University of California at Berkeley, and headed a department in a Biotech company co-founded by Nobel Laureate Manfred Eigen, before taking up his current position.
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The book is strong on the basics, with appropriate treatments of fundamental molecular spectroscopy leading on to more recent application in single-molecule manipulation and analysis. (Chemistry World, August 2009)
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