Endogenous Toxins: Targets for Disease Treatment and Prevention, 2 Volume Set

Wiley-VCH is pleased to announce the timely publication of a unique new reference on a hitherto neglected topic. Endogenous Toxins: Targets for Disease Treatment and Prevention is the only comprehensive handbook on a rising concern for our aging and progressively overfed world population.

Contrary to common belief, a great many human diseases are not dependent on outside factors (such as pathogens or hazardous chemicals), but are caused by molecules generated within the body. These so-called endogenous toxins come in many varieties and their presence can be due to malnutrition, an imbalanced diet, excessive eating or drinking, or genetic defects. There is a growing awareness of these "silent toxins" which are ever-present and largely determine our risk of developing chronic diseases such as diabetes, metabolic syndrome or neurodegeneration.

Endogenous Toxins: Targets for Disease Treatment and Prevention is the very first resource to tie together all the current knowledge from many disciplines. Until now this has only been available from widely dispersed sources in the primary literature. The importance of this publication cannot be underestimated, with diet- and metabolism-related diseases having become a prime global health concern.

The authors, both of whom are leaders in the field, have designed a truly comprehensive one-stop reference for researchers and professionals in toxicology, pharmacology and medicine. They present the complete picture on what is currently known about endogenous toxins, including their generation, modes of action, resulting disease conditions, and available countermeasures.

Endogenous Toxins: Targets for Disease Treatment and Prevention will appeal to a broad group of toxicologists, biochemists, nutrition specialists and physiologists, as well as food scientists and the food industry.

CONTENTS

Part 1 systematically covers important toxic molecule species, including metabolic intermediates and reactive oxygen species.

Part 2 discusses the role of genetically determined metabolic malfunctions, such as galactosemia, hyperlipidemia, porphyria, hemochromatosis and related conditions.

Part 3 discusses acquired and chronic diseases caused or exacerbated by endogenous toxins, such as hepatic injury, asthma, rheumatism, colorectal cancer, reperfusion diseases, neurodegeneration and aging.

Part 4 reviews current strategies to control and minimize the effect of endogenous toxins, either by nutritional or pharmacological interventions.