Catalytic Asymmetric Friedel-Crafts Alkylations

GENERAL ASPECTS AND HISTORICAL BACKGROUND
Introduction
General Aspects and Historical Background
Catalytic Enantioselective FC Reactions: An Introduction
MICHAEL ADDITION
Chelating Alpha, Beta-Unsaturated Compounds
Simple Alpha, Beta-Unsaturated Substrates
Nitroalkenes
ADDITION TO CARBONYL COMPOUNDS
Aldehydes/Ketones
Imines
NUCLEOPHILIC ALLYLIC ALKYLATION AND HYDROARYLATION OF ALLENES
Introduction
Allylic Alkylations
Metallo-Catalyzed Hydroarylation of Allenes
NUCLEOPHILIC SUBSTITUTION ON CSP3 CARBON ATOMS
Ring-Opening of Epoxides
Direct Activation of Alcohols
UNACTIVATED ALKENES
Introduction
Early Studies
Rh(I)-Catalyzed Enantioselective Hydroarylation of Iminoarenes
Pt(II)-Catalyzed Enantioselective Hydroarylation of Alkenylidoles
Au(II)-Catalyzed Enantioselective Hydroarylation of Allenylindoles
Conclusions and Outlook
Experimental: Selected Procedures
CATALYTIC ASYMMETRIC FRIEDEL-CRAFTS ALKYLATIONS IN TOTAL SYNTHESIS
Introduction
Total Synthesis of Indole-Containing Compounds
Total Synthesis of Pyrrole-Containing Compounds
Friedel-Crafts Alkylation of Furan Derivatives in Total Synthesis
Friedel-Crafts Alkylation of Arenes in Total Synthesis
Asymmetric Synthesis of Natural Products Based on Diastereoselective Friedel-Crafts Reactions
INDUSTRIAL FRIEDEL-CRAFTS IN CHEMISTRY
Introduction
Green Chemistry and the Friedel-Crafts Reaction
Heterogeneous Catalysts for the Friedel-Crafts Reaction
Large Scale Hydrocarbon Processing
Conclusions and Perspectives