Enzyme Catalysis in Organic Synthesis, Third, Completely Revised and Enlarged Edition, 3 Volume Set

VOLUME 1


PART I PRINCIPLES OF ENZYME CATALYSIS

Introduction -
Principles and Historical Landmarks of Enzyme Catalysis in Organic Synthesis
Concepts in Biocatalysis
Discovery of Enzymes
Rational Design of Enzymes
Directed Evolution of Enzymes
Production and Isolation of Enzymes
Reaction and Process Engineering

PART II HYDROLYSIS AND FORMATION OF C-O BONDS

Hydrolysis and Formation of Carboxylic Acid Esters
Hydrolysis and Formation of Epoxides
Hydrolysis and Formation of Glycosidic Bonds
Addition of Water to C¼C Bonds and its Elimination
Industrial Application and Processes Forming C-O Bonds


VOLUME 2

PART III HYDROLYSIS AND FORMATION OF C-N BONDS


Hydrolysis of Nitriles to Amides
Hydrolysis of Nitriles to Carboxylic Acids
Hydrolysis of Amides
Hydrolysis and Formation of Hydantoins
Hydrolysis and Synthesis of Peptides
C-N Lyases Catalyzing Addition of Ammonia, Amines, and Amides to C¼C and C¼O Bonds
Application of Transaminases
Industrial Applications and Processes Using Enzymes Acting on C-N Bonds

PART IV FORMATION AND CLEAVAGE OF C-C BONDS

Aldol Reactions
Acyloin and Benzoin Condensations
Cleavage and Formation of Cyanohydrins
Industrial Application and Processes Using Carbon-Carbon Lyases

PART V HYDROLYSIS AND FORMATION OF P-O BONDS

Hydrolysis and formation of P-O Bonds

PART VI REDUCTIONS

Reduction of Ketones and Aldehydes to Alcohols
Reduction of C¼C Double Bonds
Reductive Amination of Keto Acids
Industrial Application of Oxidoreductase catalyzed Reduction of Ketones and Aldehydes

VOLUME 3
PART VII OXIDATIONS

Oxyfunctionalization of C-H Bonds
Oxyfunctionalization of C-C Multiple Bonds
Oxidation of Alcohols, Aldehydes, and Acids
Baeyer-Villiger Oxidations
Aromatic Oxidations
Oxidation of C-N Bonds
Oxidation at Sulfur and Oxidation of Amino Groups
Halogenation
Industrial Application and Processes Using Biocatalysts for Oxidation Reactions

PART VIII ISOMERIZATIONS

Isomerizations
Industrial Application and Processes Using Isomerases

PART IX EXTENDED APPLICATIONS OF ENZYME CATALYSIS

Enzymatic Catalytic Promiscuity and the Design of New Enzyme Catalyzed Reactions
Catalytic Antibodies
Chemoenzymatic Dynamic Kinetic Resolution and Related Dynamic Asymmetric Transformations
Biocatalysis in Material Science
Industrial Applications of Enzymes in Emerging Areas
PART X TABULAR SURVEY OF AVAILABLE ENZYMES

Tabular Survey of Available Enzymes