Surface Enhanced Raman Spectroscopy: Analytical, Biophysical and Life Science Applications

Preface

BASIC ELECTROMAGNETIC THEORY OF SERS
Introduction
Plasmon Resonances and Field Enhancements
Field Enhancement Distribution and Localization
Electromagnetic Model for the SERS and Fluorescence Enhancement Factors
The Magnitude of the SERS Enhancement Factor in Typical Cases
Conclusions

NANOPARTICLE SERS SUBSTRATES
Introduction
Preparation and Stability of Metal Nanoparticle Colloidal SERS Substrates
Characterization of Nanoparticle-Based SERS Substrates
Nanoparticles on the Unfunctionalized Solid Surface as SERS Substrates
Conclusion and Outlook

QUANTITATIVE SERS METHODS
Introduction
SERS Media
Stability and Shelf Life
Reproducibility and Internal Standards
Selectivity
Conclusion

SINGLE-MOLECULE- AND TRACE DETECTION BY SERS
Introduction
Experiments and Results
Conclusions

DETECTION OF PERSISTENT ORGANIC POLLUTANTS BY USING SERS SENSORS BASED ON ORGANICALLY FUNCTIONALIZED Ag NANOPARTICLES
Introduction
Inclusion Hosts
Contact Hosts
Occlusion Hosts
Conclusions

SERS AND PHARMACEUTICALS
Introduction
SERS of Antipyretics and Analgesics
SERS of Antimalarials
SERS of Anticarcinogenics andf Antimutagenics
Concluding Remarks

SERS AND SEPARATION SCIENCE
Introduction
SERS and Capillary Electrophoresis (CE)
SERS and Liquid Chromatography (LC)
SERS and Gas Chromatography (GC)
SERS and Thin Layer Chromatography (TLC)
Other Separation Methods
Conclusions

SERS AND MICROFLUIDICS
Introduction
Lab-on-a-Chip Technology
Microfluidic Platforms and Application for SERS
Summary

ELECTROCHEMICAL SERS AND ITS APPLICATION IN ANALYTICAL, BIOPHYSICAL AND LIFE SCIENCE
Electrochemical Surface-Enhanced Raman Spectroscopy
Features of Electrochemical Surface-Enhanced Raman Spectroscopy
Experimental Techniques of EC-SERS
Applications of EC-SERS
Perspectives

ELECTRON TRANSFER OF PROTEINS AT MEMBRANE MODELS
Introduction
Model Membranes and Membrane Models
Methods for Probing Electron Transfer Processes of Cytochrome c at Coated Electrodes
The Unusual Distance Dependence of the Interfacial Electron Transfer Process
Electron Transfer and Protein Orientational Dynamics
Electric Field Effects on the Electron Transfer Dynamics
Electron Transfer and Protein Structural Changes
Overall Description of the Mechanism and Dynamics of the Interfacial Processes
Interfacial Electric Fields and the Biological Functions of Cytochrome c

QUANTITATIVE DNA ANALYSIS USING SURFACE-ENHANCED RESONANCE RAMAN SCATTERING
Introduction
SERRS Surfaces
Raman Reporters
SERRS DNA Probes
Sensitivity
Multiplexing
Assays
Conclusion

SERS MICROSCOPY: NANOPARTICLE PROBES AND BIOMEDICAL APPLICATIONS
Introduction
SERS Nanoparticle Probes
Biomedical Applications of SERS Microscopy
Summary and Outlook

1-P AND 2-P EXCITED SERS AS INTRACELLULAR PROBE
From Tags to Probes: Challenges in Intracellular Probing
Probing of Intracellular Parameters
Surface-Enhanced Hyper Raman Scattering and Its Potential in Studies of Cells

SURFACE- AND TIP-ENHANCEMENT CARS
Introduction
CARS: Coherent Anti-Stokes Raman Scattering
Local Enhancement of CARS by Metallic Nanostructures
Surface-Enhanced CARS
Tip-Enhanced CARS