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Biomimetic Organic Synthesis, 2 Volume Set

Erwan Poupon (Editor), Bastien Nay (Editor)
ISBN: 978-3-527-32580-1
1024 pages
June 2011
Biomimetic Organic Synthesis, 2 Volume Set (3527325808) cover image
In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature.

Volume 1 describes the biomimetic synthesis of alkaloids.

Volume 2 covers terpenes, polyketides, and polyphenols.

A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook.

Key features:

  • Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field.
  • Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.
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VOLUME 1
PART I BIOMIMETIC TOTAL SYNTHESIS OF ALKALOIDS
Biomimetic Synthesis of Ornithine/Arginine and Lysine-Derived Alkaloids: Selected Examples
Biomimetic Synthesis of Alkaloids Derived from Tyrosine: The Case of FR-901483 and TAN-1251 Compounds
Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Indolemonoterpene Alkaloids
Biomimetic Synthesis of Alkaloids Derived from Tryptophan: Dioxopiperazine Alkaloids
Biomimetic Synthesis of Alkaloids with a Modified Indole Nucleus
Biomimetic Synthesis of Manzamine Alkaloids
Biomimetic Synthesis of Marine Pyrrole-2-Aminoimidazole and Guanidinium Alkaloids
Biomimetic Syntheses of Alkaloids with a Non-Amino Acid Origin
Biomimetic Synthesis of Azole- and Aryl-Peptide Alkaloids
Biomimetic Synthesis of Indole-Oxidized and Complex Peptide Alkaloids
VOLUME 2
PART II BIOMIMETIC SYNTHESIS OF TERPENOIDS AND POLYPRENYLATED NATURAL COMPOUNDS
Biomimetic Rearrangements of Complex Terpenoids
Polyprenylated Phloroglucinols and Xanthones
PART III BIOMIMETIC SYNTHESIS OF POLYKETIDES
Polyketide Assembly Mimics and Biomimetic Access to Aromatic Rings
Biomimetic Synthesis of Non-Aromatic Polycyclic Polyketides
Biomimetic Synthesis of Polyether Natural Products via Polyepoxide Opening
Biomimetic Electrocyclization Reactions toward Polyketide-Derived Natural Products
PART IV BIOMIMETIC SYNTHESIS OF POLYPHENOLS
Biomimetic Synthesis and Related Reactions of Ellagitannins
Biomimetic Synthesis of Lignans
Synthetic Approaches to the Resveratrol-Based Family of Oligomeric Natural Products
Sequential Reactions Initiated by Oxidative Dearomatization. Biomimicry or Artifact?
PART V FRONTIERS IN BIOMIMETIC CHEMISTRY: FROM BIOLOGICAL TO BIO-INSPIRED PROCESSES
The Diels?Alderase Never Ending Story
Bio-Inspired Transfer Hydrogenations
Life?s Single Chirality: Origin of Symmetry Breaking in Biomolecules
PART VI CONCLUSION: FROM NATURAL FACTS TO CHEMICAL FICTIONS
Artifacts and Natural Substances Formed Spontaneously
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Erwan Poupon is a pharmacist, he obtained his PhD in organic chemistry under the supervision of Dr. Nicole Kunesch and Prof. Henri-Philippe Husson in 2000 at Paris-Descartes University. He was subsequently a post-doctoral fellow at the University of California at San Diego working with Prof. Emmanuel Theodorakis. He then joined the faculty at the School of Pharmacy of Paris-Sud University where he is now Professor of pharmacognosy and natural product chemistry. His fields of interest relate to the chemistry of natural products, including biomimetic synthesis and chemical biology.

Bastien Nay obtained his diploma of Pharmacy in 1998 and his PhD in organic chemistry in 2000 under the guidance of Prof. Joseph Vercauteren at the School of Pharmacy of Bordeaux, France. He then joined Prof. J. Stephen Clark's group as a post-doctoral fellow at the University of Nottingham, UK. In 2003 he was appointed research scientist at the CNRS, now working and teaching at the National Museum of Natural History in Paris, where he is managing the natural product chemistry team. His research interests non only concern the synthetic strategies towards natural products, but also their origin and raion d'Ítre.
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"The volumes will be widely acclaimed as an important, meticulously researched and engagingly presented
contribution unrivalled in comprehensiveness and quality . . . A single most thoroughly self-consistent and comprehensively inspiring work that will ensure the continued development in an exciting field." (Current Engineering Practice, 2011)
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