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Handbook of Metathesis, Volume 2: Applications in Organic Synthesis, 2nd Edition

ISBN: 978-3-527-33949-5
744 pages
May 2015
Handbook of Metathesis, Volume 2: Applications in Organic Synthesis, 2nd Edition (3527339493) cover image


The second edition of the "go-to" reference in this field is completely updated and features more than 80% new content, with emphasis on new developments in the field, especially in industrial applications. No other book
covers the topic in such a comprehensive manner and in such high quality.

Edited by the Nobel laureate R. H. Grubbs and D. J. O´Leary, Volume 2 of the 3-volume work focusses on applications in organic synthesis. With a list of contributors that reads like a "Who's-Who" of metathesis, this is an
indispensable one-stop reference for chemists in academia and industry.

View the set here - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527334246.html

Other available volumes:

Volume 1: Catalyst Development and Mechanism, Editors: R. H. Grubbs and A. G. Wenzel - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339485.html

Volume 3: Polymer Synthesis, Editors: R. H. Grubbs and E. Khosravi - http://www.wiley.com/WileyCDA/WileyTitle/productCd-3527339507.html

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Table of Contents

About the Editors xxxiii

Preface xxxvii

List of Contributors of Volumes 1 and 2 xxxix

Abbreviations and Acronyms xli

Theory and instrumentation of mass spectrometry and its application to drug metabolism 393
Stacy L. Gelhaus and Ian A. Blair

Mass spectral interpretation 419
Li-Kang Zhang and Birendra N. Pramanik

Computational approaches in drug biotransformation studies: metabolite prediction 457
Nigel J. Waters and Michelle K. Dennehy

High-throughput metabolite detection and quantitative–qualitative bioanalysis 481
Donghui Cui and Sean Yu

Metabolic stability screen in drug discovery 499
Chuang Lu

Application of triple-quadrupole and its hybrid mass spectrometers for the identification of drug metabolites 523
Zhi-Yi Zhang, Chandra Prakash, and Lin Xu

Role of ion trap LC-MS techniques for the identification of drug metabolites 553
Robert D. Pelletier and W. George Lai

Drug metabolite identification with high-resolution mass spectrometry 567
Haiying Zhang and Mingshe Zhu

Strategies for the identification of unusual and novel metabolites using derivatization, hydrogen–deuterium exchange (HDX), and liquid chromatography-nuclear magnetic resonance (LC-NMR) spectroscopy techniques 591
Amin Kamel, Shawn Harriman, and Chandra Prakash

The use of nanoelectrospray mass spectrometry for the quantitation of metabolites in the absence of synthetic standards 619
Jing-Tao Wu

Quantitation of drug metabolites by radioactivity detection including accelerator mass spectrometry (AMS) 633
Angus N.R. Nedderman and Mark E. Savage

Application of quantitative NMR in drug metabolism studies 661
Abdul E. Mutlib

Early assessment of exposure of drug metabolites in humans using mass spectrometry 693
Natalia A. Penner, Joanna Zgoda-Pols, and Chandra Prakash

Profiling and characterization of bioactive substances of herbal medicine and their metabolites using mass spectrometry 723
Xiaoyan Chen

Application of in silico metabolism and environmental degradation data to support chemical PBT assessment 787
Sabcho Dimitrov, Gilman Veith, and Ovanes Mekenyan

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Author Information

Robert H. Grubbs received his Ph.D. from Columbia University for work with Ron Breslow. After a postdoctoral year with Jim Collman at Stanford University, he joined the faculty at Michigan State University. In 1978, he moved to the California Institute of Technology, where he is now the Victor and Elizabeth Atkins Professor of Chemistry. Among many other awards he received the Nobel Prize in 2005 for his research on the metathesis reaction. His research interests include polymer chemistry, organometallic catalysis, and development of new synthetic organic methodology.

Daniel J. O´Leary received his PhD at UCLA in the group of Prof. Frank A. L. Anet. Following an NSF postdoctoral fellowship with Prof. Yoshito Kishi at Harvard University, he became Assistant Professor at Pomona College, where he is presently the Carnegie Professor of Chemistry.His research interests are in the area of organic synthesis, isotope effects, and nuclear magnetic resonance. 

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