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Emerging Areas in Bioengineering

Ho Nam Chang (Editor), Sang Yup Lee (Series Editor), Jens Nielsen (Series Editor), Gregory Stephanopoulos (Series Editor)
ISBN: 978-3-527-34088-0
904 pages
February 2018
Emerging Areas in Bioengineering (3527340882) cover image


With more than 40 contributions from expert authors, this is an extensive overview of all important research topics in the field of bioengineering, including metabolic engineering, biotransformations and biomedical applications.

Alongside several chapters dealing with biotransformations and biocatalysis, a whole section is devoted to biofuels and the utilization of biomass. Current perspectives on synthetic biology and metabolic engineering approaches are presented, involving such example organisms as Escherichia coli and Corynebacterium glutamicum, while a further section covers topics in biomedical engineering including drug delivery systems and biopharmaceuticals. The book concludes with chapters on computer-aided bioprocess engineering and systems biology.

This is a part of the Advanced Biotechnology book series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.
Invaluable reading for biotechnologists and bioengineers, as well as those working in the chemical and pharmaceutical industries.
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Table of Contents

Contents to Volume 1

List of Contributors xvii

About the Series Editors xxxiii

Part I Biocatalysis 1

1 Introduction to Emerging Areas in Bioengineering 3
Ho Nam Chang

2 Over-Expression of Functionally Active Inclusion Bodies of Enzymes in Recombinant Escherichia coli 21
Wen-Chien Lee and Shao-Yen Hsu

3 Enzymatic Reactions in Ionic Liquids 35
Ngoc Lan Mai and Yoon-Mo Koo

4 Enzyme Immobilization on Nanoparticles: Recent Applications 67
Cheng-Kang Lee and Ai-Nhan Au-Duong

5 Whole Cell Biocatalysts Using Enzymes Displayed on Yeast Cell Surface 81
Kentaro Inokuma, Tomohisa Hasunuma, and Akihiko Kondo

6 Design of Artificial Supramolecular Protein Assemblies by Enzymatic Bioconjugation for Biocatalytic Reactions 93
Geisa A.L.G. Budinova, Yutaro Mori, and Noriho Kamiya

7 Production of Valuable Phenolic Compounds from Lignin by Biocatalysis: State-of-the-Art Perspective 105
Somchart Maenpuen, Ruchanok Tinikul, Pirom Chenprakhon, and Pimchai Chaiyen

Part II Biofuels and Renewable Energy from Biomass 125

8 Biofuels, Bio-Power, and Bio-Products fromSustainable Biomass: Coupling Energy Crops and OrganicWaste with Clean Energy Technologies 127
Serpil Guran, Foster A. Agblevor, and Margaret Brennan-Tonetta

9 Potential Lignocellulosic Biomass Resources in ASEAN Countries 163
Shankar Ramanathan, Madihah Md Salleh, Adibah Yahya, Huszalina Hussin, Wan R.Z.Wan Dagang, Shaza E. Mohamad, Zaharah Ibrahim, Rohaya Mohd Noor, Nursyifaaiyah Abdul Aziz, Zulkefflizan Jamaludin, and Syariffah Nuratiqah Syed Yaacob

10 Volatile Fatty Acid Platform: Concept and Application 173
Nag-Jong Kim, Seong-Jin Lim, and Ho Nam Chang

11 Biological Pretreatment of Lignocellulosic Biomass for Volatile Fatty Acid Production 191
Suraini Abd-Aziz, Mohamad F. Ibrahim, and Mohd A. Jenol

12 Microbial Lipid Production from Volatile Fatty Acids by Oleaginous Yeast 203
Gwon W. Park, Nag-Jong Kim, and Ho Nam Chang

13 Gasification Technologies for Lignocellulosic Biomass 215
Su J. Jeon, Soo H. Jeong, Beom J. Kim, and Uen D. Lee

14 Separation of Butanol, Acetone, and Ethanol 255
Di Cai, Song Hu, Peiyong Qin, and Tianwei Tan

15 Overview of Microalgae-Based Carbon Capture and Utilization 287
Ye Sol Shin, Jaoon Y. H. Kim, and Sang Jun Sim

16 Bioengineering of Microbial Fuel Cells: FromExtracellular Electron Transfer Pathway to Electroactive Biofilm 295
Yang-Yang Yu, Dan-Dan Zhai, and Yang-Chun Yong

Part III Synthetic Biology and Metabolic Engineering 305

17 Genome Editing Tools for Escherichia coli and Their Application in Metabolic Engineering and Synthetic Biology 307
Chandran Sathesh-Prabu and Sung K. Lee

18 Synthetic Biology for Corynebacterium glutamicum: An Industrial Host forWhite Biotechnology 321
Han Min Woo

19 Metabolic Engineering of Solventogenic Clostridia for Butanol Production 331
Sang-Hyun Lee and Kyoung Heon Kim

20 Metabolic Engineering of Microorganisms for the Production of Lactate-Containing Polyesters 349
Yokimiko David, Sang Yup Lee, and Si Jae Park

21 MicrobialMetabolic Engineering for Production of Food Ingredients 359
Eun J. Oh, Yong-Su Jin, and Jin-Ho Seo

Contents to Volume 2

List of Contributors xix

About the Series Editors xxxv

Part IV Products 373

22 Application of Lactic Acid Bacteria for Food Biotechnology 375
Ling Li and Nam Soo Han

23 Biopolymers Based on Raw Materials from Biomass 399
Jonggeon Jegal

24 Bacterial Biofertilizers: High Density Cultivation 429
S. Mutturi and Virendra S. Bisaria

25 Current Research in Korean Herbal Cosmetics 441
Jun S. Park, Ga Y. Cho, and Sung-Il Park

Part V Biosensing and Nanobiotechnology 463

26 Advanced Genetic Engineering of Microbial Cells for Biosensing Applications 465
Do Hyun Kim, Byung Jo Yu, and Moon II Kim

27 Bioelectronic Nose 477
Hwi Jin Ko, Eun Hae Oh, and Tai Hyun Park

28 Noninvasive Optical Imaging Techniques in Clinical Application 497
Uk Kang and Soo-Jin Bae

29 Advanced Short Tandem Repeat Genotyping for Forensic Human Identification 509
Yong T. Kim, Hyun Y. Heo, and Tae S. Seo

30 DNA Microarray-Based Technologies to Genotype Single Nucleotide Polymorphisms 531
Jung H. Park, Ye L. Jung, Kyungmee Lee, Changyeol Lee, Batule Bhagwan, and Hyun G. Park

31 Advanced Applications of Nanoscale Measuring Systemfor Biosensors 557
Jong M. Kimand Sang-Mok Chang

32 Biosynthesis and Applications of Silver Nanoparticles 579
Bipinchandra K. Salunke and Beom Soo Kim

Part VI Biomedical Engineering and Biopharmaceuticals 591

33 Smart Drug Delivery Devices and Implants 593
Ki Su Kim, Ho Sang Jung, Hyunsik Choi, Songeun Beack, Hyemin Kim, Jong Hwan Mun,Myeong Hwan Shin, Do Hee Keum, Heebeom Koo, Seok Hyun Yun, and Sei Kwang Hahn

34 Controlled Delivery Systems of Protein and Peptide Therapeutics 607
Hwiwon Lee,Minsoo Cho, Jeong Ho Lee, Jong HwanMun, ByungWoo Hwang, Hyemin Kim, and Sei Kwang Hahn

35 Cell Delivery Systems Using Biomaterials 617
Youngro Byun and Jee-Heon Jeong

36 Bioengineered Cell-Derived Vesicles as Drug Delivery Carriers 631
Vipul Gujrati and Sangyong Jon

37 Advanced Genetic Fusion Techniques for Improving the Pharmacokinetic Properties of Biologics 645
Seung R. Hwang and JinW. Park

38 Mussel-Mimetic Biomaterials for Tissue Engineering Applications 655
Yun Kee Jo, Hyo Jeong Kim, Eun Yeong Jeon, Bong-Hyuk Choi, and Hyung Joon Cha

39 Mass Production of Full-Length IgG Monoclonal Antibodies from Mammalian, Yeast, and Bacterial Hosts 679
Sang T. Jung and Dong-Il Kim

40 Recent Advances in Mass Spectrometry-Based Proteomic Methods for Discovery of Protein Biomarkers for Complex Human Diseases 697
Sangchul Rho, Hyobin Jeong, Sehyun Chae, Hee-Jung Jung, Sanghyun Ahn, Yun-Hwa Kim, Ju-Young Lee, Soyoung Choi, and Daehee Hwang

Part VII Computer-Aided Bioprocess Design and Systems Biology 713

41 Overview on Bioprocess Simulation 715
Shin Je Lee, Dae Shik Kim, JongMin Lee and Chonghun Han

42 Bioprocess Simulation and Scheduling 723
Doug Carmichael, Charles Siletti, Alexandros Koulouris, and Demetri Petrides

43 Metabolism-Combined GrowthModel Construction and Its Application to Optimal Bioreactor Operation 761
Dong H. Jeong, Jung H. Kim, and JongM. Lee

44 Software Applications for Phenotype Analysis and Strain Design of Cellular Systems 771
Meiyappan Lakshmanan, Lokanand Koduru, and Dong-Yup Lee

45 Metabolic Network Modeling for Computer-Aided Design of Microbial Interactions 793
Hyun-Seob Song,William C. Nelson, Joon-Yong Lee, Ronald C. Taylor, Christopher S. Henry, Alexander S. Beliaev, Doraiswami Ramkrishna, and Hans C. Bernstein

Index 803

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Author Information

Ho Nam Chang is Professor Emeritus at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He studied at Seoul National University (South Korea) and received his Master and Ph.D. degrees from Stanford University (USA) in 1971 and 1975. After this time, he returned to Korea and became Professor at KAIST, a position he hold until his retirement in 2010. In 1990, he was elected Director of the Bioprocess Engineering Research Center at KAIST. During his scientific career, Ho Nam Chang became a Humboldt Fellow at the University of Erlangen (Germany, 1980 to 1981), President of the Korean Society for Biotechnology and Bioengineering (1994 to 1995), Member of the Presidential Council on Science and Technology of Korea (1995 to 1997) and Honorary Professor at Nanjng University of Technology (China).
Sang Yup Lee is Distinguished Professor at the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He is currently the Director of the Center for Systems and Synthetic Biotechnology, Director of the BioProcess Engineering Research Center, and Director of the Bioinformatics Research Center. He received numerous awards, including the National Order of Merit, the Merck Metabolic Engineering Award and the Elmer Gaden Award. Lee is the Editor-in-Chief of the Biotechnology Journal and Associate Editor and board member of numerous other journals. Lee is currently serving as a member of Presidential Advisory Committee on Science and Technology (Korea).

Jens Nielsen has a PhD degree (1989) in Biochemical Engineering from the Danish Technical University (DTU), and after that established his independent research group and was appointed full Professor there in 1998. He was Fulbright visiting professor at MIT in 1995-1996. At DTU he founded and directed the Center for Microbial Biotechnology. In 2008 he was recruited as Professor and Director to Chalmers University of Technology, Sweden. Jens Nielsen has received numerous Danish and international awards including the Nature Mentor Award, and is member of several academies, including the National Academy of Engineering in USA and the Royal Swedish Academy of Science. He is a founding president of the International Metabolic Engineering Society.

Professor Gregory Stephanopoulos is the W. H. Dow Professor of Chemical Engineering at the Massachusetts Institute of Technology (MIT, USA) and Director of the MIT Metabolic Engineering Laboratory. He is also Instructor of Bioengineering at Harvard Medical School (since 1997). He has been recognized by numerous awards from the American Institute of Chemical Engineers (AIChE) (Wilhelm, Walker and Founders awards), American Chemical Society (ACS), Society of industrial Microbiology (SIM), BIO (Washington Carver Award), the John Fritz Medal of the American Association of Engineering Societies, and others. In 2003 he was elected member of the National Academy of Engineering (USA) and in 2014 President of AIChE.
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