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Thermal Biophysics of Membranes

ISBN: 978-3-527-40471-1
378 pages
September 2007
Thermal Biophysics of Membranes (3527404716) cover image
An overview of recent experimental and theoretical developments in the field of the physics of membranes, including new insights from the past decade.
The author uses classical thermal physics and physical chemistry to explain our current understanding of the membrane. He looks at domain and 'raft' formation, and discusses it in the context of thermal fluctuations that express themselves in heat capacity and elastic constants. Further topics are lipid-protein interactions, protein binding, and the effect of sterols and anesthetics. Many seemingly unrelated properties of membranes are shown to be intimately intertwined, leading for instance to a coupling between membrane state, domain formation and vesicular shape. This also applies to non-equilibrium phenomena like the propagation of density pulses during nerve activity.
Also included is a discussion of the application of computer simulations on membranes.
For both students and researchers of biophysics, biochemistry, physical chemistry, and soft matter physics.
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1. Membranes: An Introduction
2. Membrane Structure
3. The Composition of Biological Membranes
4. Introduction into Thermodynamics
5. Water
6. Lipid Melting
7. Phase Diagrams
8. Statistical Models for Lipid Melting
9. Lipid-Protein Interactions
10. Diffusion
11. Electrostatics
12. Adsorption, Binding and Insertion of Proteins
13. Elasticity and Curvature
14. Thermodynamics of the Elastic Constants
15. Structural Transitions
16. Relaxation Processes in Membranes
17. Permeability
18. Nerve Pulse Propagation
19. Anestesia

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Thomas Heimburg, Prof. Dr., born 1960 in London, Ph.D. 1989 in Physics and Habilitation in 1995 in Biophysics both from the University of Göttingen.
Since 1997, Heisenberg Fellow of the "Deutsche Forschungsgemeinschaft" at the Max Planck Institute for Biophysical Chemistry in Göttingen and head of the independent subgroup "Membrane Thermodynamics".
Since 2001, appointment as an extramural professor in the Physics department of the University of Göttingen
About 35 peer-reviewed articles and 3 book chapters. Invited talks at several national and international meetings.
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