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Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications

ISBN: 978-3-527-60419-7
320 pages
March 2006
Modern Fluoroorganic Chemistry: Synthesis, Reactivity, Applications (3527604197) cover image

Description

In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides.
This long-awaited book represents an indispensable source of high quality information for everyone working in the field.
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Table of Contents

INTRODUCTION
Why Organofluorine Chemistry
History
The Basic Materials
The Unique Properties of Organofluorine Compounds
SYNTHESIS OF COMPLEX ORGANOFLUORINE COMPOUNDS
Introduction of Fluorine
Perfluoroalkylation
Special Fluorinated Groups
Syntheses with Fluorinated Building Blocks
FLUOROUS CHEMISTRY
Fluorous Biphasic Catalysis
Fluorous Synthesis and Combinatorial Chemistry
FLUOROPHARMACEUTICALS
Why Fluorinated Pharmaceuticals?
Lipophilicity
Hydrogen bonding and Electrostatic Interactions
Metabolic Stabilization
Bioisosteric Mimicking
Orthogonal Reactivity and Suicide Inhibition
LIQUID CRYSTALS FOR ACTIVE MATRIX LCDs
Calamatic Liquid Crystals: A Short Introduction
Functioning of an Active Matrix LCD
Why Fluorinated Liquid Crystals?
Fluorinated Polar Groups
Fluorinated Bridge Structures
REFERENCES
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Author Information

Peer Kirsch received his PhD under the supervision of Prof. Staab at the Max Planck Insitute for Medical Research in Heidelberg. He joined the Liquid Crystal Division of Merck KGaA in 1995 and his research interest is the application of fluorine chemistry for the design and synthesis of liquid crystals.
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Reviews

"Von einem geschichtlichen Überblick bis hin zu neuesten Methoden und Anwendungen zeigt das Buch die gesamte Bandbreite an fluororganischer Chemie auf."

www.organische-chemie.ch

"... der Autor, ein renommierter Industriemechaniker, bewies bei der Auswahl der Themen ein feines Gespür für die wichtigsten Aspekte dieses noch in der Entwicklung befindlichen Forschungsgebiets. .... Das Layout ist ansprechend und die graphische Darstellung der Strukturformeln klar und einheitlich. Ein zweckmäßiges Sachwortvrzeichnis rundet den positiven Eindruck ab. .... Praktiker auf dem Gebiet werden das Buch bald als Referenzwerk zu schätzen wissen, aber auch fortgeschrittenen Studenten kann es als vorlesungsbegleitende Lektüre gute Dienste leisten.

G. K. Surya Prakash, Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, Angewandte Chemie, 2. Märzheft 2005-117/10 + International Edition 2005-44/10
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