|
E-book
Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and BioavailabilityISBN: 978-3-527-60515-6
E-book
602 pages
March 2006
 Purchase This E-book
This price is valid for United States. Change location to view local pricing and availability.   
|
I. STUDIES OF MEMBRANE PERMEABILITY AND ORAL ABSORPTION
Physicochemical Approaches to Drug Absorption
High Throughput Measurement of log D and pKa
High Throughput Measurement of Membrane Permeability
Biosensors to Study Intestinal Drug Absorption
Cell Cultures of Caco-2, MDCK and Other Cell Lines: General Overview
Cell Cultures in Drug Discovery: An Industrial Perspective
Role of Animals in Absorption and Bioavailability Estimation
In Vivo Permeability Studies in the GI Tract
II. DRUG DISSOLUTION AND SOLUBILITY
Gastrointestinal Dissolution and Absorption of Drugs
Solubility Screening in Drug Discovery
Impact of Salt/Crystal Forms on Solubility and Permeability in Drug Development
Prediction of Solubility
III. ROLE OF TRANSPORTERS AND METABOLISM IN ORAL ABSORPTION
Transporters in the GI Tract
Role of Transporters in Liver Extraction of Drugs
Gut Wall Metabolism
Modified Cell Lines
IV. COMPUTATIONAL APPROACHES TO DRUG ABSORPTION AND BIOAVAILABILITY
Intestinal Absorption: The Role of Polar Surface Area
Calculated Molecular Properties and Multivariate Statistical Analysis in Absorption Prediction
2D and 3D Molecular Descriptors in ADME prediction
Simulation of the Absorption Process
Prediction of Bioavailability
Towards P-gp Structure-Activity Relationships
V. DRUG DEVELOPMENT ISSUES
Biopharmaceutical Classification System: How Important Are Solubility and Permeability?
Prodrugs
Physicochemical Approaches to Drug Absorption
High Throughput Measurement of log D and pKa
High Throughput Measurement of Membrane Permeability
Biosensors to Study Intestinal Drug Absorption
Cell Cultures of Caco-2, MDCK and Other Cell Lines: General Overview
Cell Cultures in Drug Discovery: An Industrial Perspective
Role of Animals in Absorption and Bioavailability Estimation
In Vivo Permeability Studies in the GI Tract
II. DRUG DISSOLUTION AND SOLUBILITY
Gastrointestinal Dissolution and Absorption of Drugs
Solubility Screening in Drug Discovery
Impact of Salt/Crystal Forms on Solubility and Permeability in Drug Development
Prediction of Solubility
III. ROLE OF TRANSPORTERS AND METABOLISM IN ORAL ABSORPTION
Transporters in the GI Tract
Role of Transporters in Liver Extraction of Drugs
Gut Wall Metabolism
Modified Cell Lines
IV. COMPUTATIONAL APPROACHES TO DRUG ABSORPTION AND BIOAVAILABILITY
Intestinal Absorption: The Role of Polar Surface Area
Calculated Molecular Properties and Multivariate Statistical Analysis in Absorption Prediction
2D and 3D Molecular Descriptors in ADME prediction
Simulation of the Absorption Process
Prediction of Bioavailability
Towards P-gp Structure-Activity Relationships
V. DRUG DEVELOPMENT ISSUES
Biopharmaceutical Classification System: How Important Are Solubility and Permeability?
Prodrugs
How to read this e-book on:
View the Series
Wiley's Methods and Principles in Medicinal Chemistry Series
