Molecular Farming: Plant-made Pharmaceuticals and Technical Proteins
March 2006, Wiley-Blackwell
Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.
PLANT PRODUCTION TECHNOLOGIES
Perennial plants as a production system for pharmaceuticals
Foreign protein expression using hairy roots and plant suspension cultures
Production of recombinant proteins in germinating seeds
Viral expression vectors
Chloroplast derived antibodies, biopharmaceuticals and edible vaccines
sIgA production in plants
Antibodies in plants and plant cell suspension cultures
Production of spider silk proteins in plants
Glycosylation of plant produced proteins
The precautionary approach to tackle the wicked problems
Requirements and expectations of Molecular Farming from the view of big pharma
Choice of crop species and improving recombinant protein levels
Gene farming in pea under field conditions: Seed specific synthesis of a bacterial exoenzyme
Within the last 15 years Prof. Dr. Rainer Fischer published over 90 research articles in leading international journals, 35 book chapters and established a strong global academic and industrial network. He is also well known within the scientific arenas for his international scientific talks, is on the editorial board of two highly ranked scientific journals and is reviewer for more than 20 journals. He has filed over 25 different patent applications and successfully secured more than 100 million Euros in financial support. Prof. Fischer serves as reviewer for multiple national and international grant agencies (EC, NATO and NSF), he is an adviser for four international Biotech companies and an active board member for two start-up companies.
“The book will be useful for molecular biologists and protein biochemists in academia and industry with an interest in molecular pharming and for anyone interested in obtaining a quick overview of the state of the field.” (Annals of Botany, 1 October 2005)"Authors from academia and industry provide a fascinating overview of current production technologies and possible future applications."
"... a valuable introduction. ... This volume, although aimed at a scientific audience, can be regarded as an early indication of a coming debate... Each chapter is concise but they all have many references ... I recommend this book."
Chemistry & Industry
"... this is an excellent book on this exciting new subject." American Journal of Therapeutics
"... covers a large amount of highly detailed material in a clear and concise manner."
Drug Development and Industrial Pharmacy