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Microsystem Engineering of Lab-on-a-chip Devices

Oliver Geschke (Editor), Henning Klank (Editor), Pieter Telleman (Editor)
ISBN: 978-3-527-60636-8
270 pages
August 2006
Microsystem Engineering of Lab-on-a-chip Devices (352760636X) cover image


Written by an interdisciplinary team of chemists, biologists and engineers from one of the leading European centers for microsystem research, MIC in Lyngby, Denmark, this book introduces and discusses the different aspects of (bio)chemical microsystem development. Unlike other, far more voluminous and theoretical books on this topic, this is a concise, practical handbook, dealing with analytical applications, particularly in the life sciences.
Topics include:
* microfluidics
* silicon micromachining
* glass and polymer micromachining
* packaging
* analytical chemistry
illustrated with examples taken mainly from ongoing research projects at MIC.
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Table of Contents


1. Introduction (Pieter Telleman).

2. Clean Rooms (Daria Petersen and Pieter Telleman).

3. Microfluidics - Theoretical Aspects (Jörg P. Kutter and Henning Klank).

4. Microfluidics - Components (Jörg Kutter, Klaus Bo Mogensen, Henning Klank, and Oliver Geschke).

5. Simulations in Microfluidics (Goran Goranovic and Henrik Bruus).

6. Silicon and Cleanroom Processing (Anders Michael Jorgensen and Klaus Bo Mogensen).

7. Glass Micromachining (Daria Petersen, Klaus Bo Mogensen, and Henning Klank).

8. Polymer Micromachining (Henning Klank).

9. Packaging of Microsystems (Gerardo Perozziello).

10. Analytical Chemistry on Microsystems (Jö P. Kutter and Oliver Geschke).

Subject Index.

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Author Information

Oliver Geschke graduated in Chemistry in 1994 at the university of Münster, Germany. He joined the Institute for Chemical and Biochemical Sensor Research, Münster, Germany, where he carried out his PhD research titles “Development and Characterization of μTAS sensors analyzing phenolic compounds and dissolved oxygen – Ways to a laboratory on a chip”. In December 1998 he joined the MIC at the Technical University of Denmark (DTU), kgs. Lyngby, Denmark, where he worked as an assistant professor on a European Project on wastewater analysers. In November 2001 he became Associated Professor at MIC where he is heading a research group “Polymeric Environmental Microsystems, POEM”. Oliver has been supervising and co-supervising a number of MSc and PhD students and postdoctoral researchers. He published about 15 papers in various journals and international conference proceedings, contributed to two textbooks and holds one patent. Apart from his teaching duties at DTU he taught in several national and international courses – mostly on matter that is covered in this book.

Henning Klank studied Physics at the Ludwig-Maximillian University in Munich, Germany, finishing with a MSc degree in experimental physics. The following years he spent at Massey University in Palmerston North, New Zealand, where he completed a PhD in Physics, working on the instrumentation for a scanning tunneling microscope. Currently Henning is working as a postdoctoral fellow at the um;TAS group at MIC at the Technical University of Denmark (DTU), kgs. Lyngby, Denmark. His general field of interest is instrumentation, automation and measurement. His most recent work at MIC involved fabrication of plastic Microsystems using infrared laser machining, particle image velocimetry and designing electronic measurement and processing equipment for Bio/Chemical MicroSystem.

Pieter Telleman received a Chemical Engineering degree from the University of Twente, Enschede, The Netherlands, in 1987 and a MSc degree in Biochemistry from the University of Nijmegen, The Netherlands in 1990. In 1995 he received his PhD in Medicine from the University of Amsterdam (Amsterdam, The Netherland). In 1995 Pieter joined the Harvard University, Boston, MA, USA as a postdoctoral fellow at the Harvard Institutes of Medicine (HIM) followed by a postdoctoral fellowship at the Harvard Medical School (HMS), He joined the MIC at the Technical University of Denmark (DTU), kgs. Lyngby, Denmark, as a group leader of the Bio/Chemical MicroSystem group in 1998. Pieter was appointed Professor in Bio/Chemical MicroSystem at the DTU on July 1, 2001 and assumed the position of center director at MIC in 2003. His research focuses on the application of micro- and nanotechnology to chemistry and the life sciences where the aim is to perform complete chemical and bio/chemical analyses on silicon, glass and plastic chips thereby improving overall performance.

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"Insgesamt ist das Buch eine nützliche Ergänzung der auf dem Markt befindlichen einschlägigen Literatur und kann als Lehrbuch für das Grundstudium oder als Einführung in die Mikrofluidik dienen."
Jaisree Moorthy, David T. Eddington, David J. Beebe, University of Wisconsin, Madison (USA)
Angewandte Chemie 2004-116/34

"Über den Bereich Lab-on-a-Chip gibt es schon das ein oder andere editierte Buch. Das hier zu diskutierende Werk ist aber nicht nur aktueller, es bietet dem Leser auch mehr. ... Das Buch bietet profunde und logisch dargelegte Information und liest sich dabei leicht. Man merkt , dass hier "Überzeugungstäter" schreiben; die Begeisterung für das Thema schwingt immer wieder durch. Das Buch wird auch seinem Titel und damit Anspruch gerecht. Der Leser wird bestens über die Ingenieuraspekte zu Lab-on-a-Chip informiert."
Volker Hessel, Mainz,
Chemie Ingenieur Technik, 11/2004

"Jetzt liegt auch eine überschaubare, praxistaugliche Einführung vor, die nicht das gesamte Gebiet der Mikroreaktoren und mikromechanischen Systeme abdecken will, sondern sich auf analytische Anwendungen in der Chemie und den Lebenswissenschaften konzentriert."

"In conclusion, the book is a useful addition to the literature and would be useful as an undergraduate textbook, to bridge the gap between the engineers and the chemists, or also as an introduction to the field of microfluidics for researchers who are unfamiliar with the field."
—Jaisree Moorthy, David T. Eddington, David J. Beebe, University of Wisconsin, Madison (USA), Angewandte Chemie, IE, 2004-43/34

"The stated goal of the authors to "allow a broad range of scientists and engineers to get interested and familiarized with this very exciting topic" is well accomplished. An excellent overview-in-a-book about lab-on-achip devices."
—Yoko Kamotani, Shuichi Takayama, University of Michigan (US), ChemBioChem, 9/2004

"I recommend this book to anyone who wants to start working on miniaturized analytical/biological applications. It is interdisciplinary and accessible not only to engineers but also to chemists and biochemists interested in understanding the basics of microfluidic systems. ... The authors have found a didactic approach to inform you about (nearly) everything you ever wanted to know about engineering lab-on-a-chip devices but were afraid to ask."
—Emmanuel Delamarche, IBM Research, Zurich Research Laboratory,
Advanced Materials, Vol. 16, No. 21, 2004; Bioworld, 6/November 2004

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