Microsystem Engineering of Lab-on-a-chip Devices
* silicon micromachining
* glass and polymer micromachining
* analytical chemistry
illustrated with examples taken mainly from ongoing research projects at MIC.
1. Introduction (Pieter Telleman).
2. Clean Rooms (Daria Petersen and Pieter Telleman).
3. Microfluidics - Theoretical Aspects (Jörg P. Kutter and Henning Klank).
4. Microfluidics - Components (Jörg Kutter, Klaus Bo Mogensen, Henning Klank, and Oliver Geschke).
5. Simulations in Microfluidics (Goran Goranovic and Henrik Bruus).
6. Silicon and Cleanroom Processing (Anders Michael Jorgensen and Klaus Bo Mogensen).
7. Glass Micromachining (Daria Petersen, Klaus Bo Mogensen, and Henning Klank).
8. Polymer Micromachining (Henning Klank).
9. Packaging of Microsystems (Gerardo Perozziello).
10. Analytical Chemistry on Microsystems (Jö P. Kutter and Oliver Geschke).
Henning Klank studied Physics at the Ludwig-Maximillian University in Munich, Germany, finishing with a MSc degree in experimental physics. The following years he spent at Massey University in Palmerston North, New Zealand, where he completed a PhD in Physics, working on the instrumentation for a scanning tunneling microscope. Currently Henning is working as a postdoctoral fellow at the um;TAS group at MIC at the Technical University of Denmark (DTU), kgs. Lyngby, Denmark. His general field of interest is instrumentation, automation and measurement. His most recent work at MIC involved fabrication of plastic Microsystems using infrared laser machining, particle image velocimetry and designing electronic measurement and processing equipment for Bio/Chemical MicroSystem.
Pieter Telleman received a Chemical Engineering degree from the University of Twente, Enschede, The Netherlands, in 1987 and a MSc degree in Biochemistry from the University of Nijmegen, The Netherlands in 1990. In 1995 he received his PhD in Medicine from the University of Amsterdam (Amsterdam, The Netherland). In 1995 Pieter joined the Harvard University, Boston, MA, USA as a postdoctoral fellow at the Harvard Institutes of Medicine (HIM) followed by a postdoctoral fellowship at the Harvard Medical School (HMS), He joined the MIC at the Technical University of Denmark (DTU), kgs. Lyngby, Denmark, as a group leader of the Bio/Chemical MicroSystem group in 1998. Pieter was appointed Professor in Bio/Chemical MicroSystem at the DTU on July 1, 2001 and assumed the position of center director at MIC in 2003. His research focuses on the application of micro- and nanotechnology to chemistry and the life sciences where the aim is to perform complete chemical and bio/chemical analyses on silicon, glass and plastic chips thereby improving overall performance.
—Jaisree Moorthy, David T. Eddington, David J. Beebe, University of Wisconsin, Madison (USA), Angewandte Chemie, IE, 2004-43/34
"The stated goal of the authors to "allow a broad range of scientists and engineers to get interested and familiarized with this very exciting topic" is well accomplished. An excellent overview-in-a-book about lab-on-achip devices."
—Yoko Kamotani, Shuichi Takayama, University of Michigan (US), ChemBioChem, 9/2004
"I recommend this book to anyone who wants to start working on miniaturized analytical/biological applications. It is interdisciplinary and accessible not only to engineers but also to chemists and biochemists interested in understanding the basics of microfluidic systems. ... The authors have found a didactic approach to inform you about (nearly) everything you ever wanted to know about engineering lab-on-a-chip devices but were afraid to ask."
—Emmanuel Delamarche, IBM Research, Zurich Research Laboratory,
Advanced Materials, Vol. 16, No. 21, 2004; Bioworld, 6/November 2004