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Nutritional Genomics: Impact on Health and Disease

ISBN: 978-3-527-60775-4
470 pages
August 2006, Wiley-Blackwell
Nutritional Genomics: Impact on Health and Disease (3527607757) cover image


Nutritional genomics paves the way for novel applications in medicine and human nutrition, and this volume presents the latest data on how genetic variation is associated with dietary response and how nutrients influence gene expression. In so doing, it brings together the various disciplines involved in this field of research, making this essential reading for nutritionists, biochemists and molecular biologists.
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Table of Contents

Nutritional Genomics: Concepts, Tools and Expectations
Nuclear Receptors: An Overview
Mechanism of Action and Cancer Therapeutic Potential of Retinoids
Nuclear Receptors and the Control of Gene Expression by Fatty Acids
Cellular Adaptation to Amino Acid Availability: Mechanisms Involved in the Regulation of Gene Expression
Transcriptional Regulation of Hepatic Genes by Insulin and Glucose
PPARs: Lipid Sensors that Regulate Cell Differentiation Processes
Advances in Selenoprotein Expression: Patterns and Individual Variations
PPARs in Atherosclerosis
Protein Synthesis and Cancer
Mutations in the PPAR Gene Relevant for Diabetes and the Metabolic Syndrome
Regulation of Lipogenic Genes in Obesity
The Genetics of Type 2 Diabetes
Gene Variants and Obesity
Gene Polymorphisms, Nutrition, and the Inflammatory Response
Gene Variants, Nutritional Parameters, and Hypertension
Gene Variants, Nutrition, and Cancer
Taste Receptors and their Variants
Cancer and Gene Variants in Enzymes Metabolizing Dietary Xenobiotics
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Author Information

Professor Regina Brigelius-Flohe is the head of the Department of Biochemistry of Micronutrients in the German Institute of Human Nutrition, Potsdam, Germany. Prior to her position in this institute, she worked in industry in the Center of Research of Gruenenthal GmbH and in the Institute for Molecular Pharmacology in Hannover, Germany. Her work has focused on understanding the mechanisms by which small nutrient molecules such as selenium and vitamin E contribute to human health

Professor Hans-Georg Joost was made scientific director of the German Institute of Human Nutrition in 2002. Throughout his career he has published more than 100 peer-reviewed papers, with a primary focus on obesity research.
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