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Infections Causing Human Cancer

ISBN: 978-3-527-60929-1
531 pages
September 2007, Wiley-Blackwell
Infections Causing Human Cancer (3527609296) cover image
Written by the Nobel Prize Laureate in Physiology or Medicine 2008

In the 1970s, the author of this work and his co-workers initially found Epstein-Barr virus DNA in Burkitt’s lymphomas and nasopharyngeal cancer and made the connection between HPV infection and cervical cancer. It was also during this period and subsequently that scientists all over the world discovered tumor-inducing bacteria, viruses, parasites, and protozoa, opening up entirely new prospects for the prevention and treatment of infection-induced cancer by vaccination.

Adopting a unifying concept and a consistent structure for the individual chapters, Professor zur Hausen provides a thorough and comprehensive overview on cancer-inducing infective agents — viruses, bacteria and parasites — and their corresponding transforming capacities and mechanisms. He does not cover the structure and molecular biology of the agents presented in great detail, but rather concentrates on those aspects that link the respective agents to human oncogenesis. As such, an extensive bibliography after each chapter permits further studies on the subject.

With a chapter on Helicobacter written by James Fox and his colleagues at Harvard University, this is an invaluable and instructive reference for all oncologists, microbiologists and molecular biologists working in the area of infections and cancer.

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HISTORICAL REVIEW
The Early Period (1898-1911)
Frustration and Successes (1912-1950)
The Period from 1950 to 1965
A First Human Tumor Virus?
The Difficult 1970s
The Re-emergence of a Concept
THE QUEST FOR CAUSALITY
Infectious Agents as Direct Carcinogens
Infectious Agents as Indirect Carcinogens
TUMORS LINKED TO INFECTIONS -
SOME GENERAL ASPECTS
Tumor Types Linked to Infections
Global Contributions of Infections to Human Cancer
Host Interactions with Potentially Carcinogenic Infections
HERPESVIRUSES AND ONCOGENESIS
Alphaherpesviridae
Betaherpesviridae
Gammaherpesviridae
PAPILLOMAVIRUSES -
A MAJOR CAUSE OF HUMAN CANCERS
Introduction
Concept of Viral Interfering Cascades
Cancers Linked to HPV Infections
Role of Co-factors
Preventive Vaccination
Therapeutic Vaccination
Therapy
HEPADNAVIRUS FAMILY
Hepatitis B Virus
Animal Hepadnaviruses
FLAVIVIRUS FAMILY
Hepatitis C Virus
RETROVIRUS FAMILY
Human T-lymphotropic Retroviruses 1 (HTLV-1)
Human T-lymphotropic Retroviruses 2 (HTLV-2)
Human Endogenous Retroviruses
Gibbon Ape Leukaemia Virus and Simian Sarcoma Virus
OTHER VIRUS INFECTIONS POSSIBLY INVOLVED IN HUMAN CANCERS
Polyomaviruses (JC, BK and SV40)
HELICOBACTER, CHRONIC INFLAMMATION AND CANCER
Discovery, Taxonomy and Genomics
Life Cycle, Specificity, and Virulence Determinants in Cancer Development
Prevention of H. Pylori Induced Cancer
Animal Models
Virulence Determinants of Enterohepatic Helicobacter Spp
Enterohepatic Helicobacter Spp. -
Are they Cocarcinogens?
PARASITES AND HUMAN CANCER
Schistosomiasis
Infection with Liver Flukes (Opisthorchis Viverrini, O. Felineus, Clonorchis Sinensis)
CANCERS WITH A POSSIBLE INFECTIOUS ETIOLOGY
Leukemias and Lymphomas
Human Breast Cancer
Other Human Cancers Possibly Linked to Infectious Events
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In 2008 Professor zur Hausen was awarded the Nobel Prize in Physiology/Medicine. Among his many other awards, he has held the Robert Koch Award, the Charles S. Mott Prize of the General Motors Cancer Research Foundation, the Paul Ehrlich and Ludwig Darmstaedter Award, the German Cancer Award, and the Federal Order of Merit, as well as six honorary degrees and seven visiting professorships.
Since 1983 Harald zur Hausen acted as chairman of the management board and scientific director of the German Cancer Research Center in Heidelberg until his retirement in 2003. Previously he worked at a range of different universtities in the USA and Germany. Professor zur Hausen has served on a large number of different scientific and policy bodies in many different countries including the European Board of Directors of HUGO, the International Scientific Advisory Committee of the French National Cancer Institute and Vice-Chairman of the German American Academic Council.
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"You should consider purchasing it." Lab Times
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Wikipedia Find more information about Harald zur Hausen
Nobel Prize in Physiology or Medicine 2008 View the official announcement
Interview Listen to a telephone interview with Harald zur Hausen immediately following the announcement of the 2008 Nobel Prize in Physiology or Medicine, 6 October 2008
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