Novel Therapeutic Proteins

Foreword (Juergen Drews)
Preface (Klaus Dembowsky and Peter Stadler)
INTRODUCTION AND OVERVIEW
Medical Applications of Recombinant Proteins in Humans
Gayle Delmonte Wetzel
RECOMBINANT HORMONES
Clinical Applications of Recombinant Human Erythropoietin (Dimitrios Spentzos and Arthur J. Sytkowski)
Human Recombinant Growth Hormone (Carmen Ariznavarreta Ruiz and Jesus A.F. Tresguerres)
Human Recombinant Follicle Stimulating Hormone (Follitropin-a) (José A. Peinado, Colin M. Howles, and Jesus A.F. Tresguerres)
RECOMBINANT CYTOKINES AND THEIR RECEPTORS
Granulocyte Colony Stimulating Factor (G-CSF) (Karl Welte)
Interferon b-1b in Multiple Sclerosis (Bernd Aufdembrinke, Reinhard Horowski, and Joachim-Friedrich Kapp)
TNF-a -Receptors as Recombinant Proteins in Treatment of Rheumatoid Arthritis (Hanns-Martin Lorenz and Joachim R. Kalden)
RECOMBINANT ENZYMES, ENZYME ACTIVATORS AND INHIBITORS
Improvement of Principles of Nature: t-PA (Rolf G. Werner and Gerhard Heusel)
The Clinical Development of Recombinant Coagulation Factor VIII (KogenateO) for the Treatment of Hemophilia A (Peter J. Larson)
Aprotinin, Recombinant Aprotinin and Recombinant Aprotinin Mutants (Klaus Dembowsky and Werner Schroeder)
RECOMBINANT VACCINES
Recombinant Hepatitis B Vaccines -- Characterization of the Viral Disease and Vaccine Production in the Methylotrophic Yeast, Hansenula polymorpha (Stephan Schaefer, Michael Piontek, Sang-Jeom Ahn, Adam Papendieck, Zbigniew A. Janowicz and Gerd Gellissen)
MONOCLONAL ANTIBODIES
Therapeutic Applications of Monoclonal Antibodies: A Clinical Overview (Mark Sopwith)
Antibody Therapy for Sepsis: Some Lessons Learned (Steven M. Opal)
An Engineered Human Antibody for Chronic Therapy: CDP571 (Mark Sopwith and Sue Stephens)
The Evolution of ReoPro(r) Clinical Development (Catherine F. Farrell, Elliot S. Barnathan and Harlan F. Weisman)
Index