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GC/MS in Clinical Chemistry

ISBN: 978-3-527-61405-9
257 pages
July 2008
GC/MS in Clinical Chemistry (3527614052) cover image
This book enables the reader to gain a rapid understanding of GC/MS analysis through a basic knowledge of the fundamental principles, linking these with simple and practical applications in the field of industrial medicine and analysis of drugs. Additional information from other specialist fields is also provided with the aim of helping the analyst to understand their relevance to the interpretation of results. The book describes efficient methods of sample preparation and quality assurance and provides information on epidemiology and pharmacology, without which drug screening is impossible.

This comprehensive overview is mainly written for the practical analyst in the clinical laboratory but it is equally suited for teaching purposes.
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PART I: FUNDAMENTAL PRINCIPLES OF ANALYSIS BY GAS CHROMATOGRAPHY AND MASS SPECTROMETRY
Physical Theory and Equipment Design
Injection and Headspace Technique
Columns and Carrier Gas
GC Detectors and Mass Spectrometry
Quantification
PART II: DRUG SCREENING
Epidemiology of the Abuse of Drugs and Medicaments
Methods of Sample Preparation for Drug Analysis
Drug Screening from Urine by GC/MS
PART III: ENVIRONMENTALLY HAZARDOUS SUBSTANCES IN WORKING MEDICINE
Quantitative Determination of Pentachlorophenol and Lindane in Blood
Headspace Gas Chromatography in Clinical Chemistry
PART IV: ORGANIZATION AND COST-EFFECTIVENESS IN THE CLINICAL LABORATORY
The Provision of Samples to the Medical Laboratory
Internal Cost Calculations in GC/MS Analysis using Drug Screening from Urine as an Example
Quality Assurance in the Clinical Laboratory using Drug Analysis as the Example
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