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Lipophilicity in Drug Action and Toxicology

Vladimir Pliska (Editor), Bernard Testa (Editor), Han Waterbeemd (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Hendrik Timmerman (Series Editor)
ISBN: 978-3-527-61498-1
E-book
463 pages
September 2008
US $155.00 Purchase This E-book

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Aus dem Inhalt:
Lipophilicity: The empirical tool and the fundamental objective/
Lipophilicity: A history/
Thermodynamics of van der Waals and hydrophobic interactions/
Intramolecular interactions encoded in lipophilicity: their nature and significance/
Lipophilicity measurement by reversed-phase high performance liquid chromatography (RP-HPLC)/
Centrifugal partition chromatography for lipophilicity measurements/
Assessment of distribution - pH profiles/
Estimation of lipophilicty by reversed-phase thin layer chromatography/
The future of log P calculation/
Theoretical calculation of partition coefficients/
Cellular automata model of partitioning between liquid phases