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Drug-Membrane Interactions

Joachim K. Seydel, Michael Wiese, Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)
ISBN: 978-3-527-61649-7
367 pages
July 2009
Drug-Membrane Interactions (3527616497) cover image
Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes.
Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given.
This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.
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INTRODUCTION
Function, Composition, and Organization of Membranes
OCTANOL-WATER PARTITION VERSUS PARTITIONING INTO MEMBRANES
ANALYTICAL TOOLS FOR THE ANALYSIS AND QUANTIFICATION OF DRUG-MEMBRANE INTERACTIONS
High-performance Liquid Chromatography (HPLC)
Displacement of 45Ca from Phospholipid Head Groups
Differential Scanning Calorimetry (DSC)
Fluorescence Techniques
Fourier Transform Infrared Spectroscopy (FT-IR)
Electron Spin Resoncance (ESR)
Small Angle Neutron and X-ray Diffraction
Nuclear Magnetic Resonance (NMR)
Circular Dichroism (CD)
UV Spectroscopy
DRUG-MEMBRANE INTERACTIONS AND PHARMACOKINETICS OF DRUGS
Drug Transport
Drug Distribution
Uptake into and Distribution within Bacterial Cells
Drug Accumulation, Toxicity, and Selectivity
DRUG-MEMBRANE INTERACTIONS AND PHARMACODYNAMICS
Drug Efficacy
Drug Resistance
COMPUTER SIMULATION OF PHOSPHOLIPIDS AND DRUG-PHOSPHOLIPID INTERACTIONS
Modeling Strategies for Studying Phospholipids and Drug-Phospholipid Interactions
Computer Simulations with Phospholipids
Concluding Remarks
INDEX
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