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The Power of Functional Resins in Organic Synthesis

ISBN: 978-3-527-62618-2
683 pages
December 2008
The Power of Functional Resins in Organic Synthesis (3527626182) cover image
While many books cover solid phase synthesis and combinatorial synthesis, this one is unique in its exclusive coverage of the other aspects of solid-phase synthesis. As such, it contains everything you need to know -- from supported reagents, to scavengers, resins, and the synthesis of biomolecules and natural products.
An invaluable companion for all chemists and biochemists working in university research and industry.
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INTRODUCTION
The (Classic Concept of) Solid Support
Molecularly Imprinted Polymers
Nanoparticles Functionalized with Bioactive Molecules: Biomedical Applications
SOLID-SUPPORTED REAGENTS AND SCAVENGERS
Oxidizing and Reducing Reagents
Base and Acid Reagents
Nucleophilic, Electrophilic, and Radical Reactions
Coupling and Introducing Building Block Reagents
Supported/Tagged Scavengers for Facilitating High-Throughput Chemistry
Metal Scavengers
RESIN-BOUND CATALYSTS
Polymer-Supported Organocatalysts
Transition Metal Catalysts
Chiral Auxiliaries on Solid Support
Immobilized Enyzmes in Organic Synthesis
RESINS FOR SOLID-PHASE SYNTHESIS
Acid-Labile Resins
Base/Nucleophile-Labile Resins
Safety-Catch and Traceless Linkers/Resins in SPOS
Photolabile and Miscellaneous Linkers/Resins
SOLID-PHASE SYNTHESIS OF BIOMOLECULES. THE STATE OF THE ART (FROM THE RESIN POINT OF VIEW)
Peptides
Oligonucleotides and their Derivatives
Oligosacharides
High Throughput Synthesis of Natural Products
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Judit Tulla-Puche is a senior scientist at the Institute for Research in Biomedicine in the group of Professor Fernando Albericio. She received her Ph.D. in chemistry at the University of Minnesota under the supervision of Professor George Barany, and then moved to the Barcelona Science Park. Her research efforts are directed at the synthesis of cyclic peptides and depsipeptides with anticancer activity, and the development of drug delivery methodologies.

Fernando Albericio is the Executive Director of the Barcelona Science Park, Professor at the University of Barcelona, and group leader at the Institute for Research in Biomedicine. His major research interests cover practically all aspects of peptide synthesis and combinatorial chemistry methodologies, as well as synthesis of peptides and small molecules with therapeutic activities. He has published over 500 papers and is currently editor of Amino Acids and the International Journal of Peptide Research and Therapeutics.
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"The editors have succeeded in providing an authoritative summary of the use of functional resins in organic synthesis. The book impresses by the enormous range of topics that are discussed. Every chemistry library in academia or industry should own a copy of this book." (Angewandte Chemie, May 2009)
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