Preface
PART I: THE START
Platinum Complexes for the Treatment of Cancer: Why the Search goes on
PART II: CISPLATIN -
HOW GOOD IS IT?
Clinical Status of Cisplatin and other Pt Antitumor Drugs
PART III: HOW DOES IT POSSIBLY WORK? -
BIOCHEMISTRY
The Response of Cellular Proteins to Cisplatin -
Damaged DNA
The Mechanism of Action of Cisplatin: From Adducts to Apoptosis
Replication of Platinated DNA and its Mutagenic Consequences
Interstand Cross-Links in Cisplatin- or Transplatin-Modified DNA
PART IV. CHEMISTRY RELEVANT TO PT-BIOMOLECULE INTERACTIONS
Platinum Complexes: Hydrolysis and Binding to N7 and N1 of Purines
Reactivity and Inertness of Pt-Nucleobase Complexes
Kinetics and Selectivity of DNA Platination
Structure and Dynamics of Pt Anticancer Drug Adducts from Nucleotides to Oligonucleotides as Revealed by NMR Methods
Pt and 15N NMR Spectroscopic Studies of Cisplatin Reactions with Biomolecules
Structural Aspects of Pt-Purine Interactions: From Models to DNA
Platinum-Sulfur Interactions involved in Antitumor Drugs, Rescue Agents and Biomolecules
Diammine- and Diamineplatinum Complexes with Non-Sulfur-Containing Amino Acids and Peptides
PART V: INORGANIC CHEMISTRY REVIVED OR INITIATED BY CISPLATIN
Platinum Blues: On the Way toward Unraveling a Mystery
Heteronuclear Pt(II) Complexes with Pyrimidine Nucleobases
Diplatinum(III) Complexes: Chemical Species more widely spread than suspected
Inorganic and Organometallic Chemistry of Cisplatin-Derived PT(III) Complexes
PART VI: NEW DEVELOPMENTS
Structure-Activity Relationships within Di- and Trinuclear Platinum Phase I Clinical Anticancer Agents
The Development of Orally-active Platinum Drugs
Methods for Screening the Potential Antitumor Activity of Platinum Compounds in Combinatorial Libraries
Computational Studies on Platinum Antitumor Complexes and their Adducts with Nucleid Acids Constituents