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Cell and Molecular Biology: Concepts and Experiments, 6th Edition

October 2009, ©2010
Cell and Molecular Biology: Concepts and Experiments, 6th Edition (EHEP000329) cover image
Designed for courses in Cell Biology offered at the Sophmore/Junior level,   Cell and Molecular Biology gives students the tools they need to understand to make the connection between cell biology and experimental data. Karp explores core concepts in considerable depth, and presents experimental detail when it helps to explain and reinforce the concept being explained. This sixth edition continues to offer an exceedingly clear presentation and excellent art program, both of which have received high praise in prior editions.
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1 Introduction to the Study of Cell and Molecular Biology.

2 The Chemical Basis of Life.

3 Bioenergetics, Enzymes, and Metabolism.

4 The Structure and Function of the Plasma Membrane.

5 Aerobic Respiration and the Mitochondrion.

6 Photosynthesis and the Chloroplast.

7 Interactions Between Cells and Their Environment.

8 Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking.

9 The Cytoskeleton and Cell Motility.

10 The Nature of the Gene and the Genome.

11 Gene Expression: From Transcription to Translation.

12 The Cell Nucleus and the Control of Gene Expression.

13 DNA Replication and Repair.

14 Cellular Reproduction.

15 Cell Signaling and Signal Transduction: Communication Between Cells.

16 Cancer.

17 The Immune Response.

18 Techniques in Cell and Molecular Biology.

Glossary.

Additional Readings.

Index.

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  • The text has been completely updated to reflect the most recent advances in cellular and molecular biology.
  • Major topical revisions include:

Chapter 1: increased coverage of metagenomes and human biogenomes.; new Human Perspectives box on embryonic stem cells; new coverage on synthetic biology.

Chapter 2: coverage on calorie restriction and longevity, coverage on treatment of Alzheimer’s disease; proteomics; GroEL,

Chapter 3: conformational changes in enzymes, obesity and diabetes treatment with AMPK.

Chapter 4: homology modeling, treatment of CF patients with Bronchitol,

Chapter 5: mitochondrial dysfunction and resulting disorders, mutant gene Polg,

Chapter 7: added coverage on integrins, focal adhesions, selectins, epithelial-mesenchymal transition, platelet activating factor.

Chapter 8: coverage on RNA interference, small RNAs, COPII coat, targeting and tethering vesicles, phosphoinostedes, 

Chapter 9: Fluorescence imaging techniques to study cytoskeleton, IF polypeptides

Chapter 10: Amphioxus genome, protein coding genes in the human genome, HAR1, AMY1, genome-wide association studies, cost of genetic sequencing.

Chapter 11: RNA polymerase, RNA silencing, small interfering RNAs, pri-mi RNA, unnatural amino acids, tRNA hybrid states, release factors, arrangement/orientation of ribosomes,

Chapter 12: Chromatin is a dynamic cellular component, heterochromatin, histone tail modifications influence chromatin structure.

Chapter 13: function of telomerase, interactions between distantly located genes, DNA microarrays, role of transcription factors in determining a cell’s phenotype, promoter elements that regulate gene expression, CH1P technique,

Chapter 14: cyclin-Cdk complexes, kinetochores, nuclear envelope, spindle assembly checkpoints, ssDNA and dsDNA,

Chapter 15: protein kinases, GPCR rhodopsin, scaffolding proteins, insulin signaling and lifespan, store-operated calcium entry, Bcl-2 proteins,

Chapter 17: DC-T cell interactions, immunological tolerance to self-antigens,

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•     Offers an appropriate balance of concepts and experimentation.  Experimental detail is offered when it helps to reinforce the concept being explained.

•     Strong illustration program includes stepped-out art to break down complex processes into steps.

•     Illustrations are paired with micrographs to help students compare the real (micrograph) with the ideal (illustration).

•     Human aspects of cell biology are integral to this text, with “Human Perspective” essays throughout.

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"This is an excellent textbook for undergraduate students and would make for an excellent course. It could also be used as supplemental text for abnormal psychology for the discussion of assessment tools, an area to which most undergraduate students do not get adequate exposure. Strongly recommended!" (Doody's, November 2010)

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Instructors Resources
Wiley Instructor Companion Site
Princeton Review MCAT Sample Test
MCAT practice tests
Experimental Pathway Questions
Written by Joel Piperberg of Millersville University these questions focus on the Experimental Pathways boxes in the text further emphasizing the experimental nature of this text. Available in WileyPLUS and on the BCS.
Clinical Case Studies
Written by Clair Walczak of Indiana University these clinical case studies provide real world clinical applications. Linked directly into the eBook in WileyPLUS and assignable in WileyPLUS with accompanying questions.
Available Materials
by Allyn Bregman
978-0-471-20133-5
November 2001, ©2002, Paperback
by Allyn Bregman, State University of New York, New Paltz. This lab manual contains over 20 projects that cover key concepts in cell and molecular biology, such as, biochemistry and cytochemistry; organelle-sand their physiology; and more advanced molecular topics, including restriction mapping strategies.
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Students Resources
Wiley Student Companion Site
Clinical Case Studies
Written by Clair Walczak of Indiana University these clinical case studies provide real world clinical applications. Linked directly into the eBook in WileyPLUS and assignable in WileyPLUS with accompanying questions.
Available Materials
by Allyn Bregman
978-0-471-20133-5
November 2001, ©2002, Paperback
by Allyn Bregman, State University of New York, New Paltz. This lab manual contains over 20 projects that cover key concepts in cell and molecular biology, such as, biochemistry and cytochemistry; organelle-sand their physiology; and more advanced molecular topics, including restriction mapping strategies.
ADDITIONAL RESOURCES
WileyPLUS
A research-based online environment for learning and assessment.
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Purchase Options
Wiley E-Text   
Cell and Molecular Biology: Concepts and Experiments, 6th Edition
ISBN : 978-0-470-56389-2
March 2010, ©2010
$82.50   BUY

Loose-leaf   
Cell and Molecular Biology: Concepts and Experiments, 6th Edition Binder Ready Version
ISBN : 978-0-470-55655-9
832 pages
November 2009, ©2010
$137.95   BUY

Hardcover   
Cell and Molecular Biology: Concepts and Experiments, 6th Edition
ISBN : 978-0-470-48337-4
832 pages
October 2009, ©2010
$210.95   BUY

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