Cell and Molecular Biology: Concepts and Experiments, 6th Edition
October 2009, ©2010
2 The Chemical Basis of Life.
3 Bioenergetics, Enzymes, and Metabolism.
4 The Structure and Function of the Plasma Membrane.
5 Aerobic Respiration and the Mitochondrion.
6 Photosynthesis and the Chloroplast.
7 Interactions Between Cells and Their Environment.
8 Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking.
9 The Cytoskeleton and Cell Motility.
10 The Nature of the Gene and the Genome.
11 Gene Expression: From Transcription to Translation.
12 The Cell Nucleus and the Control of Gene Expression.
13 DNA Replication and Repair.
14 Cellular Reproduction.
15 Cell Signaling and Signal Transduction: Communication Between Cells.
17 The Immune Response.
18 Techniques in Cell and Molecular Biology.
- The text has been completely updated to reflect the most recent advances in cellular and molecular biology.
- Major topical revisions include:
Chapter 1: increased coverage of metagenomes and human biogenomes.; new Human Perspectives box on embryonic stem cells; new coverage on synthetic biology.
Chapter 2: coverage on calorie restriction and longevity, coverage on treatment of Alzheimer’s disease; proteomics; GroEL,
Chapter 3: conformational changes in enzymes, obesity and diabetes treatment with AMPK.
Chapter 4: homology modeling, treatment of CF patients with Bronchitol,
Chapter 5: mitochondrial dysfunction and resulting disorders, mutant gene Polg,
Chapter 7: added coverage on integrins, focal adhesions, selectins, epithelial-mesenchymal transition, platelet activating factor.
Chapter 8: coverage on RNA interference, small RNAs, COPII coat, targeting and tethering vesicles, phosphoinostedes,
Chapter 9: Fluorescence imaging techniques to study cytoskeleton, IF polypeptides
Chapter 10: Amphioxus genome, protein coding genes in the human genome, HAR1, AMY1, genome-wide association studies, cost of genetic sequencing.
Chapter 11: RNA polymerase, RNA silencing, small interfering RNAs, pri-mi RNA, unnatural amino acids, tRNA hybrid states, release factors, arrangement/orientation of ribosomes,
Chapter 12: Chromatin is a dynamic cellular component, heterochromatin, histone tail modifications influence chromatin structure.
Chapter 13: function of telomerase, interactions between distantly located genes, DNA microarrays, role of transcription factors in determining a cell’s phenotype, promoter elements that regulate gene expression, CH1P technique,
Chapter 14: cyclin-Cdk complexes, kinetochores, nuclear envelope, spindle assembly checkpoints, ssDNA and dsDNA,
Chapter 15: protein kinases, GPCR rhodopsin, scaffolding proteins, insulin signaling and lifespan, store-operated calcium entry, Bcl-2 proteins,
Chapter 17: DC-T cell interactions, immunological tolerance to self-antigens,
• Strong illustration program includes stepped-out art to break down complex processes into steps.
• Illustrations are paired with micrographs to help students compare the real (micrograph) with the ideal (illustration).
• Human aspects of cell biology are integral to this text, with “Human Perspective” essays throughout.