Textbook

Cell and Molecular Biology: Concepts and Experiments, 6th Edition

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Designed for courses in Cell Biology offered at the Sophmore/Junior level, Cell and Molecular Biology gives students the tools they need to understand to make the connection between cell biology and experimental data. Karp explores core concepts in considerable depth, and presents experimental detail when it helps to explain and reinforce the concept being explained. This sixth edition continues to offer an exceedingly clear presentation and excellent art program, both of which have received high praise in prior editions.

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Table of Contents

1 Introduction to the Study of Cell and Molecular Biology.

2 The Chemical Basis of Life.

3 Bioenergetics, Enzymes, and Metabolism.

4 The Structure and Function of the Plasma Membrane.

5 Aerobic Respiration and the Mitochondrion.

6 Photosynthesis and the Chloroplast.

7 Interactions Between Cells and Their Environment.

8 Cytoplasmic Membrane Systems: Structure, Function, and Membrane Trafficking.

9 The Cytoskeleton and Cell Motility.

10 The Nature of the Gene and the Genome.

11 Gene Expression: From Transcription to Translation.

12 The Cell Nucleus and the Control of Gene Expression.

13 DNA Replication and Repair.

14 Cellular Reproduction.

15 Cell Signaling and Signal Transduction: Communication Between Cells.

16 Cancer.

17 The Immune Response.

18 Techniques in Cell and Molecular Biology.

Glossary.

Additional Readings.

Index.

New To This Edition

The text has been completely updated to reflect the most recent advances in cellular and molecular biology.
Major topical revisions include:

Chapter 1: increased coverage of metagenomes and human biogenomes.; new Human Perspectives box on embryonic stem cells; new coverage on synthetic biology.

Chapter 2: coverage on calorie restriction and longevity, coverage on treatment of Alzheimer’s disease; proteomics; GroEL,

Chapter 3: conformational changes in enzymes, obesity and diabetes treatment with AMPK.

Chapter 4: homology modeling, treatment of CF patients with Bronchitol,

Chapter 5: mitochondrial dysfunction and resulting disorders, mutant gene Polg,

Chapter 7: added coverage on integrins, focal adhesions, selectins, epithelial-mesenchymal transition, platelet activating factor.

Chapter 8: coverage on RNA interference, small RNAs, COPII coat, targeting and tethering vesicles, phosphoinostedes,

Chapter 9: Fluorescence imaging techniques to study cytoskeleton, IF polypeptides

Chapter 10: Amphioxus genome, protein coding genes in the human genome, HAR1, AMY1, genome-wide association studies, cost of genetic sequencing.

Chapter 11: RNA polymerase, RNA silencing, small interfering RNAs, pri-mi RNA, unnatural amino acids, tRNA hybrid states, release factors, arrangement/orientation of ribosomes,

Chapter 12: Chromatin is a dynamic cellular component, heterochromatin, histone tail modifications influence chromatin structure.

Chapter 13: function of telomerase, interactions between distantly located genes, DNA microarrays, role of transcription factors in determining a cell’s phenotype, promoter elements that regulate gene expression, CH1P technique,

Chapter 14: cyclin-Cdk complexes, kinetochores, nuclear envelope, spindle assembly checkpoints, ssDNA and dsDNA,

Chapter 15: protein kinases, GPCR rhodopsin, scaffolding proteins, insulin signaling and lifespan, store-operated calcium entry, Bcl-2 proteins,

Chapter 17: DC-T cell interactions, immunological tolerance to self-antigens,

Hallmark Features

• Offers an appropriate balance of concepts and experimentation. Experimental detail is offered when it helps to reinforce the concept being explained.

• Strong illustration program includes stepped-out art to break down complex processes into steps.

• Illustrations are paired with micrographs to help students compare the real (micrograph) with the ideal (illustration).

• Human aspects of cell biology are integral to this text, with “Human Perspective” essays throughout.

Reviews

"This is an excellent textbook for undergraduate students and would make for an excellent course. It could also be used as supplemental text for abnormal psychology for the discussion of assessment tools, an area to which most undergraduate students do not get adequate exposure. Strongly recommended!" (Doody's, November 2010)