Essential Biochemistry, 2nd Edition
January 2010, ©2011
Within each chapter, the chemistry that underlies biochemical phenomena is presented using examples of actual molecules and reactions, along with explanations of basic chemical principles. In addition, the biological context is provided, in many cases, by focusing on a disease or other familiar issue. Much of this material has been consolidated in new, brief Clinical Notes features. Descriptions of some laboratory methods appear in the new Tools and Techniques sections for appropriate chapters. These sections are brief, but include actual data to illustrate the techniques, rather than a strictly theoretical descripttion of the methods. .Molecular structure and biochemical processes are explored in detail through a set of media exercises that are fully integrated with the text.
This new edition continues to approach biochemistry as a guidebook rather than a catalog, allowing the student to master the material at several levels while minimizing the need for rote memorization.
- Depth of coverage over breadth of coverage - for example, Chapter 6 describes in detail the mechanism of one enzyme - chymotrypsin, rather than presenting many mechanisms superficially.
- Some traditional topics with few applications have been eliminated. For example, amino acid titration, detailed pathways of amino acid and nucleotide metabolism, and carbohydrate nomenclature have been omitted in order to make room for newer material, such as proteomics, genetic disease, and the use of enzyme inhibitors as drugs.
- Each chapter is designed to be self-contained.
- Within each chapter, Sample Calculations show how to use key equations.
- Each chapter ends with a large selection of problems, including many multi-step case-type problems that require students to apply information rather than simply recall memorized details. In this edition, the authors included more problems that provide students with increased opportunities to interpret raw data and apply their knowledge to novel situations. In addition, a new feature, Bioinformatics Exercises require the use of online biological databases and software tools.
- The electronic media (website) are fully integrated with and complement the text. The interactive exercises/animations and the questions based on them do not merely echo material from the text but instead focus on themes such as three-dimensional shape and molecular motions - processes that can be best illustrated via the computer.
- Reminders to explore the web-based animations, guided explorations, and interactive exercises appear at appropriate places within the chapters. The text includes additional cross-references to specific topics in the on line exercises.
1. The Chemical Basis of Life.
2. Aqueous Chemistry.
3. From Genes to Proteins.
4. Protein Structure.
5. Protein Function.
6. How Enzymes Work.
7. Enzyme Kinetics and Inhibition.
8. Lipids and Membranes.
9. Membrane Transport.
Part Two: Metabolic Reactions.
12. Overview of Metabolism and Free Energy.
13. Glucose Metabolism.
14. The Citric Acid Cycle.
15. Oxidative Phosphorylation.
17. Lipid Metabolism.
18. Nitrogen Metabolism.
19. Regulation of Mammalian Fuel Metabolism.
Part Three: Management of Genetic Information.
20. DNA Replication and Repair.
21. Transcription and RNA.
22. Protein Synthesis.
- New Chapter 11, Carbohydrate Chemistry, consolidates carbohydrate coverage, including basic structure and nomenclature.
- Two large chapters in the 1e have been split into smaller, more manageable chapters:
- Chapter 4, will become Chapter 4, Protein Structure and Chapter 5, Myoglobin and Hemoglobin: A Study of Protein Function replace 1e Chapter 4, Myoglobin and Hemoglobin: A Study of Protein Structure and Function
- Chapter 9, Lipids and Membranes and Chapter 10, Membrane Function replaces 1e Chapter 8, Biological Membranes.
Key Concepts at the beginning of each section help focus students on learning objectives for the section.
Clinical Notes explore the biochemical basis of disease and its treatment;, including typical clinical symptoms, an explanation of the relevant biochemistry, and questions that prompt students to draw connections to their knowledge of molecular structure, metabolism, and so on.
Tools & Techniques sections in the appropriate chapters address real world laboratory methods and include actual data to illustrate the techniques rather than a theoretical approach to the methods.
Increased Problem-Solving opportuhites through the inclusion of additional problems and simple questions that assess understanding of basic concepts This edition also include increased opportunities for students to practice recognizing, drawing, and otherwise manipulating simple molecule
Bioinformatics Exercises require students ‘utilization of online biological databases and software tools to solve exercises addressing DNA and protein sequences, protein three-dimensional structure, enzymes and metabolic pathways, and the genetic basis of metabolic diseases.
- This Chapter in Context at the beginning of each chapter helps orient the student to the main topics of the chapter and how they relate to surrounding chapters.
- Key Concepts at the beginning of each major heading and Concept Review Questions at the end of each section help students use the text as guidebook.
- A Closer Look boxes features biochemical applications, human health, and other topics that can enrich student understanding of biochemistry.
- Sample Calculations illustrate the use of quantitative data in biochemistry, including thermodynamics, acid base chemistry, net charges, binding phenomena, enzyme kinetics, transport processes, equili
- Online Resources Reminders to explore the online resources in WileyPLUS appear at appropriate places in the chapter.
- Clinical Notes boxes explore in detail the biochemistry behind certain human diseases and are accompanied by a set of questions that could be assigned as homework (answers are available at the instruc
- Tools and Techniques sections showcase of biochemistry and provide an overview of some key experimental techniques that students are likely to encounter in their reading or laboratory experience.
- Chapter Summary highlights important concepts, grouped by section.
- Glossary Terms, includes key terms, highlighted in text.
- Bioinformatics Projects are designed to introduce students to the online databases and software tools of bioinformatics.
- 400 New Problems. The end of chapter problem sets for the second edition is greatly expanded, for a total of over 1,000 problems.