Biochemistry, 4th Edition
December 2010, ©2011
Guide to Media Resources xvi
PART I INTRODUCTION AND BACKGROUND 1
1 Life 3
2 Aqueous Solutions 40
3 Thermodynamic Principles: A Review 52
PART II BIOMOLECULES 65
4 Amino Acids 67
5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82
6 Techniques of Protein and Nucleic Acid Purifications 129
7 Covalent Structures of Proteins and Nucleic Acids 163
8 Three-Dimensional Structures of Proteins 221
9 Protein Folding, Dynamics, and Structural Evolution 278
10 Hemoglobin: Protein Function in Microcosm 323
11 Sugars and Polysaccharides 359
12 Lipids and Membranes 386
PART III MECHANISMS OF ENZYME ACTION 467
13 Introduction to Enzymes 469
14 Rates of Enzymatic Reactions 482
15 Enzymatic Catalysis 506
PART IV METABOLISM 557
16 Introduction to Metabolism 559
17 Glycolysis 593
18 Glycogen Metabolism 638
19 Signal Transduction 671
20 Transport through Membranes 744
21 Citric Acid Cycle 789
22 Electron Transport and Oxidative Phosphorylation 823
23 Other Pathways of Carbohydrate Metabolism 871
24 Photosynthesis 901
25 Lipid Metabolism 940
26 Amino Acid Metabolism 1019
27 Energy Metabolism: Integration and Organ Specialization 1088
28 Nucleotide Metabolism 1107
PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143
29 Nucleic Acid Structures 1145
30 DNA Replication, Repair, and Recombination 1173
31 Transcription 1260
32 Translation 1338
33 Viruses: Paradigms for Cellular Function W-1
34 Eukaryotic Gene Expression W-53
35 Molecular Physiology W-165
(Chapters 33–35 are available on our website, www.wiley.com/college/voet)
Judith Voet received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education.
- Many new and updated protein and nucleic acid structures
- Next generation DNA sequencing technologies
- New methods of protein structure prediction and design
- Discussion of glycomics
- How transmembrane proteins are inserted into membranes
- Updated discussions on vesicle formation and fusion
- Mechanism of nitric oxide synthase
- Structural characterization of G protein-coupled receptors
- Structures of (Na+-K+)-, Ca2+-, and (H+-K+)-ATPases
- ABC Transporters
- Voltage-gated ion channels
- Structures of all components of the electron transport system
- Structures of photosystems I and II
- Structures of fatty acid synthases
- Structure of topoisomerase II
- Mechanism of helicases
- Updated mechanisms of DNA replication
- DNA replication initiation
- Replication of mitochondrial DNA
- Mechanism of recombination
- Structure and mechanism of RecBCD
- Structure and mechanism of RNA polymerase II
- Structure and mechanism of Rho factor
- Structure of a group I intron
- Functions of RNAi
- Mechanism of ribosomal polypeptide synthesis
- Mechanism of DNA loading in phage heads
- Structure of chromatin
- As in past editions, the chemical basis of modern Biochemistry is presented in a thorough and uncompromising fashion. Don and Judy Voet are scholars and teachers who have dedicated their careers to their students and this text.
- A splendid art program of over 3000 figures presents both classical and contemporary concepts, experiments, and techniques.
- A lucid and elegant writing style captures the historical foundations of contemporary Biochemistry focusing on the scientific process rather than presenting Biochemistry as a body of static facts isolated from the flesh-and-blood work of experimentalists.
- Themes throughout the text integrate a vast amount of material. The unity of evolutionary processes, the interdependence of elaborate biological control systems and cascades, and the important biomedical consequences of understanding life at the molecular level are themes woven into the text to give students an intellectually satisfying journey, not just a dry presentation of topics and techniques.
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