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Biochemistry, 4th Edition

December 2010, ©2011
Biochemistry, 4th Edition (EHEP001782) cover image
The "Gold Standard" in Biochemistry text books, Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.
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Guide to Media Resources xvi

PART I INTRODUCTION AND BACKGROUND 1

1 Life 3

2 Aqueous Solutions 40

3 Thermodynamic Principles: A Review 52

PART II BIOMOLECULES 65

4 Amino Acids 67

5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology 82

6 Techniques of Protein and Nucleic Acid Purifications 129

7 Covalent Structures of Proteins and Nucleic Acids 163

8 Three-Dimensional Structures of Proteins 221

9 Protein Folding, Dynamics, and Structural Evolution 278

10 Hemoglobin: Protein Function in Microcosm 323

11 Sugars and Polysaccharides 359

12 Lipids and Membranes 386

PART III MECHANISMS OF ENZYME ACTION 467

13 Introduction to Enzymes 469

14 Rates of Enzymatic Reactions 482

15 Enzymatic Catalysis 506

PART IV METABOLISM 557

16 Introduction to Metabolism 559

17 Glycolysis 593

18 Glycogen Metabolism 638

19 Signal Transduction 671

20 Transport through Membranes 744

21 Citric Acid Cycle 789

22 Electron Transport and Oxidative Phosphorylation 823

23 Other Pathways of Carbohydrate Metabolism 871

24 Photosynthesis 901

25 Lipid Metabolism 940

26 Amino Acid Metabolism 1019

27 Energy Metabolism: Integration and Organ Specialization 1088

28 Nucleotide Metabolism 1107

PART V EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION 1143

29 Nucleic Acid Structures 1145

30 DNA Replication, Repair, and Recombination 1173

31 Transcription 1260

32 Translation 1338

33 Viruses: Paradigms for Cellular Function W-1

34 Eukaryotic Gene Expression W-53

35 Molecular Physiology W-165

(Chapters 33–35 are available on our website, www.wiley.com/college/voet)

xii

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Donald Voet received a Ph.D. in chemistry from Harvard University and did postdoctoral research in the Biology Department at MIT. Don took up a faculty position in the department of chemistry at the University of Pennsylvania, upon completing his postdoctoral work. He has been a visiting scholar at Oxford University, the University of California San Diego, and the Weismann Institute of Science in Israel.

Judith Voet received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox  Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education.

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  • Many new and updated protein and nucleic acid structures
  • Next generation DNA sequencing technologies
  • New methods of protein structure prediction and design
  • Discussion of glycomics
  • How transmembrane proteins are inserted into membranes
  • Updated discussions on vesicle formation and fusion
  • Mechanism of nitric oxide synthase
  • Structural characterization of G protein-coupled receptors
  • Structures of (Na+-K+)-, Ca2+-, and (H+-K+)-ATPases
  • ABC Transporters
  • Voltage-gated ion channels
  • Structures of all components of the electron transport system
  • Structures of photosystems I and II
  • Structures of fatty acid synthases
  • Structure of topoisomerase II
  • Mechanism of helicases
  • Updated mechanisms of DNA replication
  • DNA replication initiation
  • Replication of mitochondrial DNA
  • Mechanism of recombination
  • Structure and mechanism of RecBCD
  • Structure and mechanism of RNA polymerase II
  • Structure and mechanism of Rho factor
  • Structure of a group I intron
  • Functions of RNAi
  • Mechanism of ribosomal polypeptide synthesis
  • Mechanism of DNA loading in phage heads
  • Structure of chromatin
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  • As in past editions, the chemical basis of modern Biochemistry is presented in a thorough and uncompromising fashion. Don and Judy Voet are scholars and teachers who have dedicated their careers to their students and this text.
  • A splendid art program of over 3000 figures presents both classical and contemporary concepts, experiments, and techniques.
  • A lucid and elegant writing style captures the historical foundations of contemporary Biochemistry focusing on the scientific process rather than presenting Biochemistry as a body of static facts isolated from the flesh-and-blood work of experimentalists.
  • Themes throughout the text integrate a vast amount of material. The unity of evolutionary processes, the interdependence of elaborate biological control systems and cascades, and the important biomedical consequences of understanding life at the molecular level are themes woven into the text to give students an intellectually satisfying journey, not just a dry presentation of topics and techniques.
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Instructors Resources
Wiley Instructor Companion Site
Image Gallery
JPG files of ALL figures and tables from the book
Test Bank
The Test Bank has over 1,000 questions containing a variety of question types including multiple choice and matching. Each question is rated by difficulty.
Image PowerPoints
The PowerPoints contain optimized versions of all figures and tables in the text with bold leader lines and large labels for classroom projection.
Bioinformatics Exercises Answers
Classroom Response Questions (Clicker Questions)
Case Study Answers
Available Materials
by Donald Voet, Judith G. Voet
978-1-118-00814-0
February 2011, ©2011, Paperback
Written by the authors, the Student Solutions Manual provides worked-out solutions to all end-of-chapter problems in the text.
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Students Resources
Wiley Student Companion Site
Bioinformatics Exercises
Written by Paul Craig, Rochester Institute of Technology, these exercises cover the contents and uses of databases related to nucleic acids, protein sequences, protein structures, enzyme inhibition, and other topics. The exercises use real data sets, pose specific questions, and prompt students to obtain information from online databases and to access software tools for analyzing this data.
Case Studies
A set of 33 case studies by Kathleen Cornely, Providence College, use problem-based learning to promote understanding of biochemical concepts. Each case presents data from the literature and asks questions that require students to apply key principles.
Guided Explorations
30 self-contained presentations, many with narration, employ extensive animated computer graphics to enhance student understanding of key topics.
Interactive Exercises
58 molecular structures from the text have been rendered in Jmol, a brower-independent interface for manipulating structure in three dimensions. Structures are paired with questions designed to facilitate comprehension of concepts.
Kinemages
A set of 22 exercises comprising 55 three-dimensional images of selected proteins and nucleic acids that can be manipulated by users.
Animated Figures
67 figures from the text, illustrating various concepts, techniques, and processes, are presented as brief animations to facilitate learning.
Available Materials
by Donald Voet, Judith G. Voet
978-1-118-00814-0
February 2011, ©2011, Paperback
Written by the authors, the Student Solutions Manual provides worked-out solutions to all end-of-chapter problems in the text.
ADDITIONAL RESOURCES
CourseSmart
Instant access to textbooks as eTextbooks.
Learn more
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Purchase Options
Wiley E-Text   
Biochemistry, 4th Edition
ISBN : 978-0-470-91410-6
1520 pages
February 2011, ©2011
$103.50   BUY

Hardcover   
Biochemistry, 4th Edition
ISBN : 978-0-470-57095-1
1520 pages
December 2010, ©2011
$274.95   BUY

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