Textbook

Fundamentals of Biochemistry: Life at the Molecular Level, 4th Edition

Donald Voet, Judith G. Voet, Charlotte W. Pratt

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Voet, Voet and Pratt's Fundamentals of Biochemistry, 4e addresses the enormous advances in biochemistry, particularly in the areas of structural biology and Bioinformatics by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. While continuing in its tradition of presenting complete and balanced coverage that is clearly written and relevant to human health and disease, Fundamentals of Biochemistry, 4e includes new pedagogy and enhanced visuals that provide a pathway for student learning. The authors are careful to present new information such that it links it to existing content, ever mindful that students assimilate new information only in the proper context. The enriched assessment content in WileyPLUS offers students the opportunity to gauge their conceptual understanding and receive immediate feedback to address misconceptions.

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Table of Contents

PART I INTRODUCTION

1 Introduction to the Chemistry of Life 1

2 Water 22

PART II BIOMOLECULES

3 Nucleotides, Nucleic Acids, and Genetic Information 40

4 Amino Acids 76

5 Proteins: Primary Structure 93

6 Proteins: Three-Dimensional Structure 127

7 Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies 176

8 Carbohydrates 217

9 Lipids and Biological Membranes 241

10 Membrane Transport 288

PART III ENZYMES

11 Enzymatic Catalysis 315

12 Enzyme Kinetics, Inhibition, and Control 355

13 Biochemical Signaling 396

PART IV METABOLISM

14 Introduction to Metabolism 436

15 Glucose Catabolism 472

16 Glycogen Metabolism and Gluconeogenesis 517

17 Citric Acid Cycle 551

18 Electron Transport and Oxidative Phosphorylation 581

19 Photosynthesis 623

20 Lipid Metabolism 657

21 Amino Acid Metabolism 712

22 Mammalian Fuel Metabolism: Integration and Regulation 767

PART V GENE EXPRESSION AND REPLICATION

23 Nucleotide Metabolism 793

24 Nucleic Acid Structure 821

25 DNA Replication, Repair, and Recombination 867

26 Transcription and RNA Processing 919

27 Protein Synthesis 962

28 Regulation of Gene Expression 1013

Solutions to Odd-Numbered Problems SP-1

Glossary G-1

Index I-1

New To This Edition

• Key Concepts: In a complex subject like biochemistry, students have difficulty recognizing the most important "takeaways" or concepts presented. Key Concepts at the beginning of each section provides the scaffolding for true understanding by better defining these important concepts.
• Checkpoint: A robust set of questions appearing at the end of every section for students to check their mastery of the section's Key Concepts. 280 NEW end of chapter problems have been added for a total of 788 end of chapter problems in the text (over 60% more than previous edition). Each chapter also includes a new category of question entitled More to Explore. More to Explore questions may ask students to extend the material they've learned in the chapter or having just read the chapter, ask that they apply the chapter's content to other topics.
• Expanded Summaries correlated to the main headings
• Process Diagrams: These visually distinct illustrations highlight important concepts and integrate descriptive text into the figure, appealing to visual learners.
• Figure Questions: Included within many captions, these questions encourage students to test their knowledge and understanding of the process being illustrated
• Meaningful art development. Many figures have been redeveloped to enhance understanding

Hallmark Features

Author reputation - The authors are well-known and highly regarded teachers, biochemical educators and researchers, bringing the highest level of accuracy, currency and scholarship to the book
Balanced coverage, explaining the chemistry behind the biology
Grounding in chemistry provides students with an understanding of reactions at the molecular level and helps students see patterns and the "big picture." FOB4e provides sample calculations and step by step walkthroughs for key equations.
Liberal use of original figures from the research literature coupled with author-developed schematics designed for clarity and understanding
Includes the most up-to-date coverage and structures, particularly in areas impacting upon human health and disease
Inclusion of BioInformatic Exercises and Case Study end of chapter questions