The Journal of Cellular Physiology publishes reports of high biological significance in areas of eukaryotic cell biology and physiology, focusing on those articles that adopt a molecular mechanistic approach to investigate cell structure and function. There is appreciation for the application of cellular, biochemical, molecular and in vivo genetic approaches, as well as the power of genomics and proteomics. In particular, the Journal actively encourages submission of high-interest papers investigating the regulation of growth and differentiation by growth factors, cytokines and their cognate receptors as well as signal transduction pathways and conditions that influence the expression, integration and activities of these physiological mediators. Similarly, the Journal actively encourages submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules as well as the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells, and the mechanisms that determine whether cells enter quiescence, proliferate or undergo apoptosis are also welcomed. Submission of papers that address contributions of the extracellular matrix to cellular phenotypes and physiological control as well as regulatory mechanisms governing fertilization, embryogenesis, gametogenesis, differentiation, development and dynamic parameters of cell motility are encouraged. Finally, the investigation of basic changes that differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.