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Immunological Reviews
Edited by:
Gary Koretzky
ISI Journal Citation Reports® Ranking: 2008: 6/121 Immunology
Impact Factor: 11.761
While each volume of Immunological Reviews is devoted to a single topic of immunological research, collectively their aim is to provide a broad and continously updated survey of advances in basic immunology and their clinical applications.
TopNews and Announcements
Dear Readers,
We are pleased to begin the 40th year of Immunological Reviews. This year will once again provide cutting edge reviews of six topics of interest to the immunology community. Immunological Reviews will continue to fill a unique niche by bringing together investigators who have made major contributions to their fields, encouraging them not only to review their area of expertise but also to emphasize their own perspective on the relationship of their work to that of others in the field. In this way, each issue of the Journal will provide a broad overview of a defined topic highlighting the newest data, emerging concepts, and areas where there is not yet agreement within the field.
This year our six volumes will emphasize how cells of the immune system are stimulated by their environment to elicit the appropriate biologic response. The first issue of 2009 tackles an area that has become increasingly important for our understanding of the initial stages of an immune response. Dr. Shizuo Akira has brought together individuals who have made seminal contributions explaining how the innate immune system is triggered by molecular patterns that differ from those expressed by the host. The articles in this volume describe the various pattern recognition receptors and how they transduce their signals, thus allowing for the rapid initiation of a protective response as soon as a pathogenic challenge is recognized.
This issue will be followed by a volume edited by Dr. Arthur Weiss examining the complex biology of kinases and phosphatases as these enzymes positively and negatively regulate immune cell responses. The contributors to this issue include investigators who have provided the most compelling evidence for the mechanisms by which protein phosphorylation and dephosphorylation exert exquisite control of key pathways in cells of both the adaptive and innate immune systems.
The third volume for 2009 addresses the key topic of costimulation in the immune system. For decades it has been known that engagement of immunoreceptors on both B and T lymphocytes is insufficient to elicit a productive immune response. Dr. Arlene Sharpe has assembled many of individuals who have made the most seminal findings that have informed the immunology community about our current understanding of how costimulation functions to enhance or repress immune system activation.
Dr. Sharpe's volume will be followed by one edited by Drs. Linda Blum and Paul Crocker informing our readers about the emerging notions of how glycosylation affects immune cell activation.
The fifth volume this year will be edited by Dr. Anjana Rao and tackles the role of calcium as a second messenger in immune cell function. This timely issue will address the mechanisms by which calcium levels are regulated in the cell, both via signals that control compartmentalization of calcium within intracellular stores and how the newly identified cell surface store operated calcium channels function to allow for calcium influx in the various cellular lineages of the immune system.
The final issue for this year will focus on how engagement of the different signaling cascades in immune cells is regulated to so that the appropriate downstream biologic response occurs. This issue, edited by Dr. André Veillette, will focus on the molecular mechanisms of the complex biology of signal integration and cross talk among receptor systems.
We are excited by the upcoming volumes of Immunological Reviews and are confident that our readers, be they trainees, individuals just starting their own laboratories, or senior investigators, will continue to find the journal a valuable resource. We are committed to provide our readers with comprehensive overviews of key topics, authored by the investigators making the most important contributions in these areas. As always, we welcome feedback from our readers at any time, and hope that each will enjoy reading all six volumes this year.
Gary Koretzky
Editor-in-Chief
Forthcoming 2009 Volumes
227 - Innate Recognition: Receptors and Signaling, Guest Editor Shizuo Akira
228 - Kinases and Phosphatases in Immune Cell Signaling, Guest Editor Art Weiss
229 - Mechanisms of Costimulation, Guest Editor, Arlene Sharpe
230 - Glycoimmunology, Guest Editor Linda Baum and Paul Crocker
231 - Calcium Signaling in Immune Cell Regulation, Guest Editor Anjana Rao
232 - Signal Integration in Immunoreceptor Function, Guest Editor André Veillette
Online Content Now Available Back to Volume 1
All back issues of this journal are available online. For further information on how to access these issues please visit our Librarian Site.
Free online access to this journal is available within institutions in the developing world through the AGORA Initiative with the Food and Agriculture Organization of the United Nations (FAO).
