Neuropathology and Applied Neurobiology
Journal of the British Neuropathological Society
Edited by:
Dr Stephen Wharton
ISI Journal Citation Reports® Ranking: 2008: 26/156 Clinical Neurology; 63/219 Neurosciences; 13/68 Pathology
Impact Factor: 3.66
Neuropathology and Applied Neurobiology is an international journal for the publication of original papers, both clinical and experimental, on problems and pathological processes in neuropathology and muscle disease. Established in 1974, this reputable and well respected journal is an international journal sponsored by the British Neuropathological Society, one of the world leading societies for Neuropathology, pioneering research and scientific endeavour with a global membership base. Additionally members of the British Neuropathological Society get 50% off the cost of print colour on acceptance of their article.
TopNews and Announcements
Neuropathology and Applied Neurobiology publishes OnlineEarly meaning that articles are published online, before the print version, in their fully citable and final form. Submitted papers receive a decision from the editorial board in an average of 30-days!
Submission to the journal is easy via Manuscript Central. Multidisciplinary papers are especially welcomed, particularly those with a neurobiological emphasis. The journal encourages work on all the relevant aspects of neural and muscle tissues in health and disease regardless of the methodology.
Free Access in the Developing World
Free online access to this journal is available within institutions in the developing world through the HINARI initiative with the World Health Organization (WHO).
Articles published online ahead of print
Articles which have been fully copy-edited and peer-reviewed are published online through our OnlineEarly feature before the print edition of this journal is published.
Online Open
Authors of articles in this journal can now choose to make their articles open access and available free for all readers through the payment of an author fee. Read more.
NIH Public Access Mandate
For those interested in the Wiley-Blackwell policy on the NIH Public Access Mandate, please visit our policy statement.
TopHighlights
Read Stephen Wharton's choice of top articles FREE online:
Review: The human premotor oculomotor brainstem system - can it help to understand oculomotor symptoms in Huntington's disease?
Volume 35, Issue 1, Pages 4-15
U. Rüb, H. Heinsen, E. R. Brunt, B. Landwehrmeyer et al
Rub et al review the function neuroanatomy and involvement of the premotor oculomotor brainstem system in Huntington's disease.
Lentivirus Tau (P301S) expression in adult amyloid precursor protein (APP)-transgenic mice leads to tangle formation
Volume 34, Issue 5, Pages 523-531
M. Osinde, F. Clavaguera, R. May-Nass et al
Using a lentiviral system to over-express mutant tau in an APP transgenic model, Osinde et al show that APP or Aβpromotes tau pathology in adult brain, independently of early developmental mechanisms.
Diagnostic value of WT1 in neuroepithelial tumours
Volume 35, Issue 1, Pages 69-81
J. Schittenhelm, R. Beschorner, P. Simon et al
This paper reports a comprehensive survey of WT1 expression in human gliomas. The work suggests that WT1 may have a role in the development of brain tumours and be of differential diagnostic value.
pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium
C. M. Monoranu, M. Apfelbacher, E. Grünblatt et al
Volume 35, Issue 3, Pages 329-337
This study from the BrainNet Europe Consortium adds to the work from this group contributing to improved standards in brain banking. This paper shows the value of tissue pH, which is dependent on pre-mortem agonal state and ischaemia, as a quality measure for brain banking.
Microcalcification after excitotoxicity is enhanced in transgenic mice expressing parvalbumin in all neurones, may commence in neuronal mitochondria and undergoes structural modifications over time
W. Maetzler, H. Stünitz, K. Bendfeldt et al
Volume 35, Issue 2, Pages 165-177
Microcalcification occurs in several neurodegenerative diseases and neuronal injury states. Maetzler et al have studied microcalcification in an excitotoxicity model. The regulation of calcium shuttling into calcium stores is relevant to the ability of neurones to respond to injury.
Pathogenesis and molecular targeted therapy of spinal and bulbar muscular atrophy
H. Adachi, M. Waza, M. Katsuno, F. Tanaka, M. Doyu, G. Sobue
This review discusses the latest in the molecular pathology and pathogenesis of SBMA. The authors discuss novel approaches to therapy and biomarker development based on advances in the understanding of pathologenesis.
Classical sheep transmissible spongiform encephalopathies: pathogenesis, pathological phenotypes and clinical disease
M. Jeffrey, L. González
This review discusses the relationship of the varied molecular phenotypes of sheep scrapie to strain diversity and clinical manifestations.
The authors also review the latest state of knowledge of peripheral nervous system and lymphoreticular involvement, which are important for disease transmission and food safety.
Genetic intratumour heterogeneity in high-grade brain tumours is associated with telomere-dependent mitotic instability
C. Glanz, et al
An investigation of the mechanisms by which complex chromosomal abnormalities develop in glioblastoma, showing that telomere-dependent abnormal chromosome segregation at mitosis is a common occurrence.
Expression of the endoplasmic reticulum stress response marker, BiP, in the central nervous system of HIV-positive individuals
K. A. Lindl, C. Akay, Y. Wang, M. G. White, K. L. Jordan-Sciutto
This paper shows that there is an up-regulation of a master regulator and an initiator of the endoplasmic reticulum stress response pathway, suggesting that the ER stress response plays a role in HIV-related neurocognitive impairment.
Limbic structures are prone to age-related impairments in proteasome activity and neuronal ubiquitinated inclusions in SAMP10 mouse: a model of cerebral degeneration
A. Shimada, H. Keino, N. Kawamura, Y. Chiba, M. Hosokawa
Ubiquitinated inclusion formation in a senescence accelerated model system, showing the importance of proteasomal impairment for neurodegeneration. Regionally selective proteasomal impairment in this model explains the regional susceptibility to inclusion formation.
