Now published monthly
Neurogastroenterology & Motility
Edited by:
Jan Tack, Keith Sharkey and Joseph Szurszewski
ISI Journal Citation Reports® Ranking: 2008: 30/156 Clinical Neurology; 15/55 Gastroenterology & Hepatology; 68/219 Neurosciences
Impact Factor: 3.48
The field of gastrointestinal motility has undergone phenomenal growth and change in the past three decades since it emerged as a distinct speciality. Neurogastroenterology & Motility provides a forum where current issues and advances relating to the motor function of the GI tract can be presented and discussed. It is of interest to both clinicians and researchers.
TopNews and Announcements
Features
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TopHighlights
Editors' Choice: Free to View
Safety Assessment of Prucalopride in Elderly Patients with Constipation: A Double-Blind, Placebo-Controlled Study, by M Camilleri
Some serotonergic prokinetic agents used for the treatment of constipation are associated with rare cardiovascular side-effects. Since chronic constipation is common in elderly patients and since many of these patients will have a history of cardiovascular disease it is paramount that any drug used to treat these patients carries low risk of adverse events. This paper describes a double-blind placebo-controlled trail of a selective 5-HT4 receptor agonist, prucalopride, and shows it to be safe and well tolerated in an elderly nursing home population with underlying cardiovascular disease.
Analysis of Gastrointestinal Physiology Using a Novel Intestinal Transit Assay in Zebrafish, by H. A. Field et al.
Zebrafish are an attractive model for the investigation of gastrointestinal development and physiology because GI transit can be observed non-invasively and in large numbers which is important for screening phenotypic alterations and pharmacological interventions.
And coming soon in January 2010…
L. reuteri ingestion and IK channel blockade have similar effect on rat colon motility and myenteric neurons. By Kunze and co-workers.
Commensal bacteria may have beneficial effects for colonic function. This study examines the effect of ingestion of L. reuteri on enteric neural activity and colonic motility and demonstrates that probiotics may affect motility by modulating the excitability of enteric neurons involved in sensory signalling from the colonic mucosa.
