Table of Contents with Internet Links
Chapter 1,
Chapter 2,
Chapter 3,
Chapter 4,
Chapter 5,
Chapter 6,
Chapter 7,
Chapter 8,
Chapter 9,
Chapter 10,
Chapter 11,
Chapter 12,
Chapter 13,
Chapter 14,
Chapter 15,
Chapter 16,
Chapter 17,
Chapter 18
Chapter 1:
Introduction to the Study of Cell Biology
How big is
a...?
Scaled images of different types of cells, from virus
particles to a human sperm cell.
Cells: O
rigins
The evolution of cellular life, types of cells, and
cellular components.
RES
PlantPat Electron Micrographs
Electron micrographs of many plant
viruses, organized by structure and nucleic acid.
Coronaviruses
One of the main causes of "the common cold"
Picornaviruses
A very old, diverse group of viruses that cause many diseases in humans,
including polio, meningitis, colds, and Hepatitis A.
Virus
Replication Tutorial
Tutorials in the form of quizzes linked to
background information about different viruses.
Beginner's Guide
to Molecular Biology
An introduction to cell
structure.
Chapter 1: Types of Cells
A brief illustrated description of prokaryotes and eukaryotes.
BioMOO, the biologists'
virtual meeting place
A MOO for biologists that is accessible via
a Web browser or telnet.
Cells Alive!
Many animations and
movies illustrating several aspects of cell biology.
Cell Biology
Chapter
Part of MIT's Biology Hypertextbook. Covers membranes,
cell types and cell division.
Microbiology -
Introductory Lecture Notes
A discussion of microbes: bacteria and
viruses.
The Microbe
Zoo
Microbial ecology, diversity and protist-metazoan
relationships.
Viruses,
Viroids, Prions, and Bacteria
Descriptions of the different
classes of prokaryotes.
The
Microbial Underground
Many links to sites on the Web regarding
microbiology, molecular biology, and medicine, as well as an online course
in medical microbiology.
Bugs in the
News
Recent events of a microbial nature, written for nontechnical
audiences.
bionet.cellbiol
Discussions about cell
biology.
Dictionary
of Science and Biotechnology
A dictionary of over 5600 life
science terms.
Virtual
Cell
A clickable image of a cell, with options for viewing
electron micrographs, diagrams, and stereographic images.
Back To Top
Chapter 2: The Chemical Basis of Life
ExPASy -
PROSITE
A database of protein families and domains. Search by
author, citation, keyword or other criteria. Submit sequences for
comparison against known families and domains.
IMB Jena Image Library of
Biological Molecules
Links to information on amino acids and
nucleic acids. Determination of secondary structure, Watson and Crick's
paper on DNA structure, and three-dimensional models of
macromolecules.
Molecules R Us
A
database of biological molecule image files viewable as static or
interactive three-dimensional images using the Rasmol program
or Chime
plugin.
HotMolecBase
A database of molecules that are promising targets for medical
applications. Detailed descriptions of structure, metabolism, isolation and
characterization, references and contacts are described for each
entry.
Chemicals in
the Cell, Part 1
Chemistry as it applies to living
cells.
Chemicals in
the Cell, Part 2
A continuation of the introduction to
biochemistry started in the previous link.
Chemistry
Review
A review of chemical principles necessary for the study of
cell biology, with problems.
Introduction
to Amino Acids
A quick introduction to amino acids, including
composition, stereochemistry, and interactive models.
bionet.molecules.peptides
Chemica
l and biological aspects of peptides.
Biotech:
Protein Sequence Databases
Links, with descriptions, of the major
protein sequence databases.
Biotech: Bio
Informatics
How a protein is characterized, from its sequence to
its three-dimensional structure
Back To Top
Chapter 3:
Energy, Enzymes and Metabolism
Glucose
Metabolism
A brief comparison of anaerobic and aerobic
metabolism.
Intracellular
Energy Sources
Molecules that "carry" energy within
cells.
Metabolism of
Fatty Acids
How energy is obtained from fatty acids.
Chemical
Energetics
The laws of thermodynamics applied to cellular
metabolism.
WMU Biology Dept.:Bios 150
Enzymes Lab
Introduction to enzymes in general, with specific
information on catechol oxidase.
Interactive
Biochemistry
Enzyme tutorial covering kinetics, amino acid
titration curves, and reversible inhibition (requires Java and Chime
plugin).
Yale's
metabolic database
A list-based metabolic database.
Enzyme
Biochemistry
Chemical energetics, enzymatic mechanisms, kinetics,
and regulation.
Enzymes
Ima
ges, including interactive 3D models, of several enzymes. Note: to view the
3D models you will need the appropriate helper
applications.
ExPASy - ENZYZME top
page
A database of enzyme nomenclature.
ExPASy -
Biochemical Pathways
A searchable database that displays graphical
maps of biochemical pathways.
EC Enzyme
A
searchable database of enzyme nomenclature, activity, and related
diseases.
Catabolism of Amino Acids
A picture of amino
acid breakdown pathways, linked to information on related enzymes and
pathways.
Back To Top
Chapter 4: The Structure and Function of the
Plasma Membrane
Chapter 2
..1: Phospholipid/Cell Membrane
The molecules that comprise the
plasma membrane of cells, and how they affect water movement across the
membrane.
BIOL 445 -
1997 Lecture Notes on the WWW
Ion channels and how they function
in nerve cells.
BIOL 445 -
1997 Lecture Notes on the WWW
Voltage- and ligand-gated ion
channels, and diseases affecting ion channels.
BIOL 445
- 1997 Lecture Notes on the WWW
Communication between nerve cells
via electrical and chemical synapses.
Membrane
Proteins Introduction
The major membrane protein classes: receptors
and transporters.
Membrane S
tructure and Composition
The architecture of cell
membranes.
Back To Top
Chapter 5: Aerobic Respiration and the
Mitochondrion
Lecture
16
The Krebs Cycle in aerobic respiration.
Bioch
emistry 2 Study Guides
A series of true/false questions (with
answers) on oxidative phosphorylation and electron transport in the
mitochondrian.
Lecture: C
ellular Respiration
The Krebs (TCA) Cycle, electron transport, and
oxidative phosphorylation and a quiz with links to related
information.
Mitochondria and Chloroplasts
Mitochondrial structure, TCA Cycle
and oxidative phosphorylation.
Glycolysis
and the Krebs Cycle
Links to several Web sources on aerobic energy
metabolism.
Glycolysis
Links to glycolysis materials as well as static and Interactive 3D
images of glycolysis enzymes and intermediates. Note: to view the 3D models
you will need the appropriate helper
applications.
TCA
Cycle
Static and Interactive 3D images of TCA Cycle molecules.
Note: to view the 3D models you will need the appropriate helper
applications.
Oxidative
Phosphorylation
Static and Interactive 3D images of enzymes,
transporters, and carriers involved in oxidative phosphorylation. Note: to
view the 3D models you will need the appropriate helper
applications.
Glycolysis
An image of glycolytic pathways linked to detailed
information about related enzymes and pathways.
Metabolism of TCA Intermediates
An image
of the TCA cycle linked to information about related metabolic pathways and
enzymes.
Back To Top
Chapter 6: Photosynthesis and the
Chloroplast
Mitochondria and Chloroplasts
Chloroplast structure and
CO2 fixation pathways.
Chloroplasts
Illustrated description of chloroplasts, with links
to information on photophosphorylation, C3 and C4
pathways and the Calvin Cycle
Photosynthesis
Chloroplast structure, pathways and enzymes involved in
photosynthesis.
Photosynthesis Problem Set 1
A self-test
linked to a glossary and tutorials on photosynthesis.
Internet
Directory for Botany - Subject Category List
Links to arboreta,
botanical societies, taxonomic databases, images, ethnobotany, paleobotany,
and other botanical sites.
Photosynthesis
Directory
The physics of light, the light and dark reactions, and
unusual forms of photosynthesis.
bionet.photosynthesis
Discussions about research on photosynthesis.
bionet.plants
Discussion about all
aspects of plant biology.
Photosynthesis
The biochemistry of photosynthesis and different
photosynthetic pathways.
Photosynthe
sis
The nature of light, the structure of chlorophyll and
chloroplasts, the light and dark reactions, and related links.
Back To Top
Chapter 7: Interactions Between Cells and Their
Environment
Lecture
5
Detailed discussion of cell adhesion and tight junctions between
cells.
Dictyosteli
um Lecture Notes
Cell-cell interactions in the slime mold,
Dictyostelium discoideum.
Video
s
Downloadable movies of phenomena related to Dictyostelium
discoideum.
Dictyostelium:
multicellular organisms
A Word 6.0 file describing the role of
cell-cell communication in the evolution of multicellular
organisms.
U of Minn. Medical
School Lecture Abstracts
Morphogenesis and cell-cell
adhesion.
Back To Top
Chapter 8: Cytoplasmic Membrane Systems:
Structure, Function, and Membrane Trafficking
Endoplasmic
Reticulum
The structure and function of the endoplasmic reticulum,
with links to information on the Golgi complex, peroxisomes, ribosomes, and
secretory pathways.
Endoplasmic
Reticulum and Golgi
ER, Golgi and protein targeting within
eukaryotic cells.
Davis
Biology 220 Spring 1998
Text only description of the way in which
cells distribute proteins to their proper locations.
Intracellular
protein sorting and transport
Illustrated lecture notes describing
intracellular protein sorting.
The Cytoskeleton in Phagocytosis
How restructuring of the cytoskeleton facilitates the uptake of
particles by cells, with a link to a movie showing phagocytosis of a yeast
cell by Dictyostelium discoideum.
Mitochondria
and Protein Sorting
Mitochondrial compartments, diseases, and
protein signals for sorting between organelles.
Vesicle-Mediated Tr
ansport
Membrane flow between the endoplasmic reticulum, Golgi
bodies, and the plasma membrane.
bionet.cellbiol.insulin
Biology and chemistry of insulin and related receptors
Back To Top
Chapter 9: The Cytoskeleton and Cell Motility
Structure,
ultrastructure and biochemistry of the vertebrate myocyte
An
overview of muscle cell components, illustrated with diagrams and
micrographs.
Physiology and
Biophysics of the Mycocyte
A discussion of muscle cell contraction
that includes methods for studying contraction at the cellular level, the
mechanism and the proteins that are involved.
Molecular
Motors
Microtubules, intermediate filaments, and motor
molecules.
Biology 590 Related
Resource Links
Links to movies showing muscle cell contraction,
cell motility as well as interactive Shockwave titles on mitosis, heart
function and how Parkinson's Disease affects basal ganglia
cells.
Mucking about with
myosin motor mutants
One laboratory's efforts to better understand
how molecular motors function, with links to related information at other
sites.
Bacterial
Motility
How some bacteria "swim" with flagella.
bionet.cellbiol.cytonet
The
cytoskeleton, plasma membrane and cell wall.
U of Minn. Medical
School Lecture Abstracts
Morphogenesis: cell motility and shape
changes.
Neural
Crest Cell Movies in FishScope
Movies showing the migration of
cells destined to become neural crest cells during zebrafish
gastrulation.
Fish Epi
dermal Cell Movies
Movies portraying several examples of cellular
and organellar motility.
Back To Top
Chapter 10: The Nature of the
Gene and the Genome
Biology
210
The anatomy of eukaryotic chromosomes: centromeres, telemeres
and chromatin (graphics-rich).
Biology
210
How DNA is coiled and packed (graphics-rich).
Supercoiled DNA
on Gels
Annotated animation demonstrating how different DNA
conformations migrate at different rates in agarose gels.
Baylor
College of Medicine's Search Launcher
Several links to DNA and
protein analysis tools.
Kyoto Encyclopedia of Genes
and Genomes
A set of interwoven databases that relate genetic and
functional information about biomolecules. It consists of maps for
metabolic and some regulatory pathways, a molecular catalog, gene catalog,
and genome maps for some species.
FlyBase
A database
of the Drosophila genome.
Nucleic
Acid Sequence Databases
Links, with descriptions, to the major
sequence databases.
Fundamenta
l Concepts in Genetics
Genes, inheritance, and investigative
methods of genetics.
Primer on Molecular Genetics
(Department of Energy)
dAn introduction to DNA, transcription and
translation.
Microbiology --
Nucleic Acids in Microbial Cells
Replication and transcription in
prokaryotes.
Back To Top
Chapter 11: Utilization of Genetic
Information: From Transcription to Translation
Codon Usage
Database
The frequency of codon use in each organism from the
GenBank sequence database is searchable through this World Wide Web site.
DNA
Binders
Interactive models of different classes of DNA binding
proteins (requires Chime
plugin).
PolIII Beta
Subunit
Interactive model of the subunit of E. coli DNA
polymerase III, which is responsible for the holoenzyme's ability to
replicate a new strand very quickly (requires Chime
plugin).
Swiss-PDB
Viewer
A program for comparing the three-dimensional structure of
several proteins at once, view electron density maps, and generating
ray-traced model images.
Tr
anscription
A brief description of transcription using E.
coli as an example.
RNA P
rocessing
Capping, polyadenylation, and spliceosomes.
Ribozy
mes
How RNA acts as a catalyst in Tetrahymena
thermophila.
The Central
Dogma of Biology
How cells convert the information contained in
DNA to make proteins.
Translation
Translating mRNA into proteins, with an emphasis on
prokaryotes.
Back To Top
Chapter 12: The Cell Nucleus and the
Control of Gene Expression
Control of Gene
Expression
How gene expression is controlled in both prokaryotes
and eukaryotes.
Bioluminescence Lecture Notes
Quorum sensing in bacteria via
the Lux operon
Lac Operon lecture notes
How the Lac operon functions in
E. coli.
Multidrug Resistance lecture notes
Operons involved in the spread
of bacterial drug resistance.
Induci
ble Genes
Well illustrated description of inducible operons, with
a link to a problem set on the molecular genetics of
prokaryotes.
Prokaryoti
c Gene Expression
Transcriptional control, regulatory sequences
and proteins, and operons.
Regul
ation of Gene Expression
Eukaryotic gene regulation:
transcriptional and post-translational control, mRNA transport, and
post-translational modifications.
Prokaryotic Gene
Regulation
Operons, including one responsible for light production
in a marine bacterium.
Prokaryotic
Genetics Mutants
How gene expression can be studied in
prokaryotes.
The
Human Transcript Map
Chromosomal maps of disease alleles, from the
Human Genome Project.
Microbiology -- Genetic Code/Regulation Lecture Notes
Eukaryotic
gene regulation.
1
..26.96.html
Eukaryotic gene structure and RNA
splicing.
Back To Top
Chapter 13: DNA Replication and Repair
DNA Da
mage and Repair
How UV light damages DNA and the enzymes that can
repair it.
Defective DNA
Repair
Descriptions of diseases caused by errors involving DNA
repair enzymes.
DNA Repair
Causes of DNA damage and mechanisms of repair in
prokaryotes.
DNA
Replication
How DNA makes copies of itself.
The Central
Dogma of Biology
How cells convert the information contained in
DNA to make proteins.
Mic
robiology -- DNA and RNA Lecture Notes
DNA structure,
replication, repair and transcription.
Microbiology --
Nucleic Acids in Microbial Cells
Replication and transcription in
prokaryotes.
Back To Top
Eukaryotic Cell Growth and Cell Cycle Part
I
A short history of research on the cell cycle.
Cell Cycle Part 2
The transition from G2 to M
phase.
Cell Cycle Part 3
The transition from G1 to S
phase.
Chromosomes and Cell Division
The first of three linked
pages on the cell cycle, mitosis and meiosis.
Cell
Division
Mitosis, meiosis and Mendelian inheritance.
Cell Division Tutorials
Self-paced tutorials, with quizzes, on
mitosis and meiosis.
How Bacteria
Grow
Factors that influence bacterial cell division.
Cell
Division: Binary Fission and Mitosis
The cell cycle, phases of
mitosis, and related links.
Back To Top
Chapter 15: Cell Signaling:
Communication between Cells and Their Environment
BIOL 445
- 1997 Lecture Notes on the WWW
How programmed cell death helps
shape neuronal networks.
Cell
Signaling
How cells respond to changes in their environment and to
signals from other cells.
Lecture 2
2
How some toxins effect cells via cyclic AMP, a second
messenger.
G-Protein
Coupled Receptor Database
Receptor sequences, mutants, models and
signalling mechanisms of over 2400 receptors.
Cell Signalling
Classes of cell-cell interactions,
receptors, signal transduction and examples.
Apoptosis
Programmed cell
death in neutrophils.
Prokaryotic Gene
Regulation
An operon responsible for light production and "quorum
sensing" in a marine bacterium.
Apoptosis on
the Net
A review of Web sources on apoptosis, from the November
issue of Nature Biotechnology.
Cell Death and
Apoptosis
Current research, questions, and other cell death-related
information.
Streptococcus
How a
bacterium kills the cells that are supposed to kill it.
Signal
Transduction Proteins
Images of some of the proteins involved in
signal transduction.
Receptors
How environmental signals trigger actions within cells.
Back To Top
Basset
Healthcare Patient Advisory Group Education
Nontechnical
descriptions of non-traditional treatments, hospice and biological factors
of cancer.
Y-ME National Breast
Cancer Organization
Information on breast cancer, including
support resources and general breast cancer information.
Cancer Control and
Prevention
Links to major research groups at the Memorial
Sloan-Kettering Cancer Center.
Pathology
6311
Lecture slides on applications of molecular cytometry to
cancer and gene therapy.
Breast Cancer Information
Clearinghouse
Links to web sites, organizations and mailing lists
about breast cancer.
Colon Connection
A long
list of links about colon cancer: images, screening, heredity, literature,
mailing lists, and a glossary.
The Prostate Cancer
Infolink
Screening, treatments, support resources related to
prostate cancer.
The Cell Cycle
and Cancer
A summary of types and origins of cancer.
Cancer
Examples
Some examples of cancer-producing mutations.
Cyberbotanica: Plant
Compounds and Chemotherapy
Information about plant compounds used
in cancer therapy and the plants that produce them.
Related
Newsgroups:
sci.med.diseases.cancer
alt.support.cancer
Back To Top
Regulation of Humoral Immunity
How major histocompatibility
complexes (MHC) prevent autoimmune responses.
Some
Biochemical Aspects of AIDS
Envelope structure, replication,
method of infection, and drug therapies.
Biology 221a -
1997
An online course on the biology of infection and
immunity.
Protease
Inhibitors
Structures of several protease inhibitors used to treat
individuals with AIDS.
Immunity an
d Opportunism
Inherited and acquired immune system defects and
some organisms take advantage of them.
Immunology
An overview of the vertebrate immune system,
with links to detailed information on humoral and cellular
immunity.
Back To Top
Chapter 18: Techniques in Cell and Molecular
Biology
Molecular Tools of
Medicine
An overview of molecular techniques used in medicine,
including Polymerase Chain Reaction, RFLP analysis, and gene
therapy.
Partial
Restriction Digestion
Annotated animation demonstrating the
digestion of a plasmid with restriction endonucleases.
Cell
Biology Laboratory Manual
Many protocols for cell biology
techniques, including electrophoresis, fractionation, microscopy and
histochemistry.
Biology
210 - GENETICS
A description of methods used for characterizing a
sequence of DNA.
Comprehensive P
rotocol Collection
Molecular biology and nematode research
protocols.
Proto
cols
Lab protocols and links to background information about yeast
genetics, cell biology and biochemistry.
Tests
In vitro assays used
by industrial toxicologists.
Mitchison Lab
Protocols
Many protocols for microinjection, cytoskeleton
immunofluorescence, antibody production, chromatin assays and microscopy,
and microtubule isolation.
Table of
Contents
A guide to different methods of sequence comparison, with
links to the actual search engines.
REBASE - The Restriction
Enzyme Database
comprehensive information on restriction enzymes,
methylases, and the organisms from which they have been isolated.
Mike
Serfas' lab protocols
Research methods for immunohistochemistry,
in situ hybridization, and RNAse protection assays.
Molecu
lar and Genetic Methods (Prof. Huberman)
Interactive exams on
molecular and genetics methods, including hybridization, PCR, restriction
enzymes, and cDNA cloning.
Microscopy: Yale
Center for Cell Imaging
A manual of techniques associated with
microscopy, including immunocytochemistry, cryosectioning, and specimen
preparation for electron microscopy.
3-D Confocal
Microscopy Home Page
An overview of 3-D laser scanning confocal
microscopy.
Micrographs from the
Yale Center for Cell Imaging
Light and electron micrographs of
viruses, bacteria and infected cells.
Recombinant DNA
Chapter Directory
Cloning, blots, PCR and DNA
fingerprinting.
Basics
of DNA Fingerprinting
A description of DNA fingerprinting,
including applications and limitations.
sci.techniques.microscopy
The field of microscopy.
NanoWorld
Gallery
The Center for Microimagery and Microanalysis,
Queensland, Australia. Images, scientific papers, and other information
about the study of organic and inorganic materials by the use of X-rays,
ions, electrons and photons.
NWFSC Molecular
Biology Protocols
Links to experimental techniques,
journals and databases in molecular biology as well as a forum for posting
questions.
Back To Top
Features:
- Experimentation
Experimental Pathways appear at the end of each chapter. These
narratives describe in detail some of the key experimental findings that
have led to scientists understand a subject from the chapter. These also
illustrate the steps or progression of a discovery.
Example:
The Acetylcholine Receptor (ch. 4)
Experiments are referenced and
explained throughout each chapter, supporting the concepts being explained
by giving historical background while not overwhelming the reader with
detail.
- The Human Perspective
Each chapter contains a section that highlights information gained
from cell research and how it effects the lives of humans. These are
particularly relevant for student pursuing medical careers in that they
illustrate how research is impacting the way medicine is practiced.
Example: The Growing Problem of Antibiotic Resistance (ch. 3)
- Illustration Program
Four-color
illustrations designed to be self-contained learning elements.
Example: chemical structure of amino acids (ch. 2)
Complex
processes "stepped-out" so students can break down the process into
manageable parts
Example: replication of bacteriophage (ch.
1)
Supplements:
- Instructor's Manual
0-471-13591-7
chapter
outlines, teaching hints, test
questions
- Transparencies
0-471-13592-5
four-color
acetates of key 75 key illustrations
- Study Guide/Problems
Workbook
0-471-14287-5
includes art from text for student
reference and review, chapter outlines and problems to
solve
- CD-ROM
ISBN pending
illustrations from text for
projection in class