Principles of Genetics, Chapters 1 - 14

1 Science of Genetics

History of Genetics Timeline
Part of the Access Excellence Project for K-12 science instruction.
Glossary
A comprehensive genetics glossary developed by the Department of Energy.
talk.origins/Evolution Echo Jargon File
Terms and phrases appearing in the talk.origins newsgroup and the Evolution Echo of Fidonet; with links to Frequently Asked Questions (FAQ)
Diving into the Gene Pool
A site that explores some ethical issues raised by the Human Genome Project. Visitors to the site can also submit comments and opinions for posting via the ETHEX mailing list.

2 Reproduction as Basis of Heredity

Introduction to Virtual FlyLab
A Web-based fly genetics lab.
A case study of genetics research applied to a medical problem.
UCSF WWW Page-The ABCs of DNA
An introduction to DNA, inheritance and molecular biotechnology.
Inheritance of Hemophilia
An illustration of how hemophilia in humans is inherited.
Recessive and Dominant Inheritance
A brief illustrated description of one mode of inheritance.
Sex-Linked Inheritance
A brief illustrated description of how genes on sex chromosomes are inherited.
Welcome to GenCalc
In this "genetic calculator" you get to choose the traits that the parents will pass on to the child and this program will tell you the percentage chance that the child will receive the trait that you have chosen.
Mendel and Heredity
A good overview of Mendelian genetics including colour display plates to assist in the explanation

3 Mendelism: the Basic Principles of Inheritance

About Johann Gregor Mendel
A short biography of Gregor Mendel from the Czech Republic (in English).
Cell Division Tutorials
A tutorial, with problems and answers, on the genetic consequences of cell division.
Genetics Lectures
A Genetics survey course home page with other Genetics links
Department of Genetics Courses
Links to course notes for Genetics at the University of Washington
MendelWeb Table of Contents
A comprehensive source of Genetics links and information, including Mendel's 1865 paper.
Classic Papers in Genetics
Descriptions of some classic Genetics papers, with links to pdf versions.
notes100996.html
Basic Genetics principles, from lecture notes at the University of Washington.
notes101596.html
An overview of agricultural genetics
Introduction to Virtual FlyLab
Background information and protocols for Genetic experiments using yeast.
Tribolium Home Page
Genetic information about the red flour beetle, Tribolium castaneum
GenScope
A novel computer program for studying genetics from the molecular to the population level.
Fundamentals of Inheritance
The principles of Mendelian inheritance.

4 Extensions of Mendelism

notes101696.html
Lecture notes on epistasis.
notes102196.html
Examples of polygenic traits.
Gene Interactions and Epistasis
A description of possible interactions between genes and mechanisms of differential gene expression.
Genetic Analysis of Vulval Development in C. elegans
An example of epistatic interactions during development.
The Pigment Parade
An example of epistasis: white pelt colora tion in cats.

5 The Chromosomal Basis of Mendelism

Tribolium Home Page
Genetic information about the red flour beetle, Tribolium castaneum
National Human Genome Research Institute
A central site for information about the Human Genome Project.
Berkeley Drosophila Genome Project
Information about a consortium that is determining the complete DNA sequence of the euchromatic genome of the fruitfly, Drosophila melanogaster.
The E. coli Genome Center
The entire genome of the bacterium E. coli.
Online Mendelian Inheritance in Man
A catalog of human genes and genetic disorders.
Sex Linkage
Practice problems involving sex linkage.

6 Variation in Chromosome Number and Structure

New Methods for Karyotyping
Karyotyping of human chromosomes using several fluorescent dyes that reveal translocations and other ano molies.
Primate Cytogenetics Network
A clearinghouse for information on primate karyotypes, ideograms and digital images, including human samples.
Karyotyping Activity
This exercise is a simulation of human karyotyping using digital images of chromosomes from actual human genetic studies.
Karyotype Samples
A link to a Shockwave for Director-based site that allows you to karyotype normal and abnormal karyotypes.
Human Genetics Problem Set
Several problems related to PCR, pedigrees, aneuploidy and sex linkage.
Drosophila Aberrations
A database of chromosomal abnormalities in Drosophila
Online Mendelian Inheritance in Man
A catalog of human genes and genetic disorders.
Featured Genes
A selected list of human disease genes, with information on chromosome location and descriptions of each disorder.
notes100296.html
Aneuploidy and chromosomal rearrangements in the study of meiosis.

7 Linkage , Crossing Over and Mapping in Eukaryotes

FlyBase Genes
A database of the Drosophila genome.
The Dog Genome Project
The techniques used and data collected on dog genes responsible for behavior and diseases.
The Maize Genome Database Project
A database of known corn genes.
Roslin Institute Online
Information on genetic research on farm animals.
Virtual Genome Center
A list of links useful for evaluating sequence data.
Primer on Molecular Genetics (Department of Energy)
Chromosome maps derived from the Human Genome Project.
Search OMIM -- Online Mendelian Inheritance in Man
A searchable database of human genes, both normal and disease-related.
Problem Index
A list of genetics problems, with answers, grouped by subject.
Introduction to Virtual FlyLab
Background information and protocols for Genetic experiments using yeast.
Tribolium Home Page
Genetic information about the red flour beetle, Tribolium castaneum
Saccharomyces Genome Database
Genomic and biological information on baker's yeast, Saccharomyces cerevisiae
GenScope
A novel computer program for studying genetics from the molecular to the population level.
VL: Genetics
Gene mapping strategies and movement of genes.
Featured Genes
Different types of DNA polymorphisms.

8 Advanced Linkage Analysis

FlyBase Genes
A database of the Drosophila genome.
The Dog Genome Project
he techniques u sed and data collected on dog genes responsible for behavior and diseases.
The Maize Genome Database Project
A database of known corn genes.
Roslin Institute Online
Information on genetic research on farm animals.
Virtual Genome Center
A list of links useful for evaluating sequence data.
Problem Index
A list of genetics problems, with answers, grouped by subject.
BCM Search Launcher
Links to molecular biology-related search engines and analysis services.
NCBI BLAST Search
A sequence analysis tool for comparing nucleotide or peptide sequences.

9 DNA and the Structure of Chromosomes

James Dewey Watson
A biography of one of the co-discoverers of the genetic code.
Virtual Genome Center
A list of links useful for evaluating sequence data.
Primer on Molecular Genetics (Department of Energy)
What chromosomes look like, with examples.
Saccharomyces Genome Database
A database containing the genome of the yeast Saccharamyces
The Molecular Basis of Genetics
Replication and estimates of genome size.

10 DNA and Chromosome Replication

Problem Index
DNA structure and replication.
mg501n12.html
DNA replication, repair, mutation and recombination.
lecture960126.html
Illustrated lecture notes on DNA structure and replication.
Topoisomerase Action
An enzyme involved in DNA replication.
DNA Replication
DNA replication. Part of MIT's Biology Hypertextbook.

11 Transcription and RNA processing

Problem Index
A list of genetics problems, with answers, grouped by subject.
UCSF WWW Page-The ABCs of DNA
An overview of the structure of DNA, genes, and chromosomes.
The Human Transcript Map
A comparison between prokaryotic and eukaryotic transcription.
Transcription of RNA from DNA
How genetic information gets from the nucleus to the rest of the cell.

12 Translation and the Genetic Code

Problem Index
The Yeast Protein Database, with links to other yeast and sequence analysis sites.
GenScope
A novel computer program for studying genetics from the molecular to the population level.
UCSF WWW Page-The ABCs of DNA
Transcription and translation.
Codon Usage D atabase
The frequency of codon use in each organism from the GenBank sequence database is searchable through this World Wide Web site.
Translation of RNA to Protein
How messenger RNAs direct protein synthesis.

13 Mutation, Recombination and DNA Repair

Barbara McClintock
A biography of the discoverer of transposable elements.
Cold Spring Harbor Laboratory Online (CLIO)
An important center for research on the genetics of cancer.
The Maize Genome Database Project
A database of known corn genes.
Primer on Molecular Genetics (Department of Energy)
An introduction to DNA, transcription and translation.
Problem Index
A list of genetics problems, with answers, grouped by subject.
Welcome to GENE:Yeast Experiments
Background information and protocols for Genetic experiments using yeast.
Tribolium Home Page
Errors in replication.

14 Definitions of the Gene

Primer on Molecular Genetics (Department of Energy)
Background information and protocols for Genetic experiments using yeast.
Glossary
A comprehensive genetics glossary developed by the Department of Energy.
James D. Watson
A biography of one of the discoverers of the structure of DNA.