Principles of Genetics, Chapters 15 - 28

15 Genetics of Viruses

Lambda lecture notes
A description of bacteriophage lambda's genome.
Virus Replication
A detailed description of viral replication.
The Biology of the HIV Virus
A brief description of the virus that causes AIDS.
Computer Visualizations of Viruses - Examples
Computer-generated images and animations of several viruses.
An Electronic Introduction To Molecular Virology
A short introduction to molecular virology, including ultrasctructure, classifcation and replication mechanisms.
The Big Picture Book of Viruses
Micrographs, reconstructions, and links to other sites for specific viruses.

16 Bacterial Genetics

Genome Sequence DataBase: Home Page
Sequences and related information, including the complete genome of Methanococcus jannaschii, Haemophilus influenzae and Mycoplasma g enitalium
Primer on Molecular Genetics (Department of Energy)
Information on the principles and strategies of sequence mapping.
Problem Index
A list of genetics problems, with answers, grouped by subject.
Microbiology -- Gen etic Code/Regulation Lecture Notes
Bacterial gene regulation.
PLP 428: Lecture notes: lecture 9
The F factor, recombination and m apping in E. coli.
Transformation/Conjugation lecture notes
Mechanisms of bacterial gene transfer.

17 Transposable Genetic Elements

FlyBase Transposons
A searchable database of fruit fly transposons.
Barbara McClintock
A biography of the discoverer of transposable elements.
Problem Index
A list of genetics problems, wi th answers, grouped by subject.
lecture20.html
Transposons that move via RNA intermediates.

18 The Genetics of Mitochondria and Chloroplasts

Part D:Mutation Experiments
An experiment involving yeast mitochondrial mutations.
Mitochondrial Inheritance
An example of non-Mendelian inheritance.
Free radical-induced mutation vs redox regulation: costs and benefits of genes in organelles
An abstract of a paper on possible selective advantages of gene movement from mitochondria and chloroplasts to the nucleus.
The UMDF Medical Article List
A reference list of mitochondrial myopathies.
The UMDF Medical Article List
A reference list of mitochondri al cytopathies.
crp 1: A Mutant in Chloroplast RNA procesing
Description of one laboratory's study of a chloroplast gene involve d in RNA processing.
Snapdragon Sequences
A database of genes from the Snapdragon, including extra-nuclear genes.

19 The Techniques of Molecular Genetics

Recombinant DNA Tutorials
A set of questions, with answers, related to recombinant DNA techniques.
The Graphics Galler
A set of short illustrated descriptions of some major concepts and techniques of molecular biology.
The Web Cutter
An online tool to create restriction maps of DNA sequences.
Shockwave Enhanced Biology Animations
Animations of Polymerase Chain Reaction (PCR) and Southern Blotting.
The Student Allele Database
A project that assists students in mapping a neutral gene as an exercise in population genetics and gene mapping.
Molecular Biology Protocols
documentation for many techniques used in molecular biological research.

20 The Molecular Analysis o f Genes & Gene Products

Internet Resources Related to Genetics and Molecular Biology
A large list of genetics and molecular biology databases, papers and newsgroups.
Basics of DNA Fingerprinting
information on the structure and function of DNA as it relates to DNA fingerprinting..
Human Genome
Mapping of mouse and human immune system genes.
Diving into the Gene Pool
A site that explores some ethical issues raised by the Human Genome Project. Visitors to the site can also submit comments and opinions for posting via the ETHEX mailing list.
TBASE: The Transgenic/Targeted Mutation Database
Information on transgenic animals and targeted mutations generated and analyzed around the world.

21 Gene Regulation in Prokaryotes

The Lac Operon
The first bacterial operon to be elucidated.
Life After the Lac Operon
Other operon s, including the Trp, His, and Lux operons.
Studying Prokaryotic Genetics
Strategies for studying bacterial gene regulation.
Prokaryotic Genetics and Gene Expression Practice Problems
Test your understanding of bacterial gene expression and regulation.
Microbiology -- Genetic Code/Regulation Lecture Notes
Bacterial gene regulation.
Joseph M. Calvo
The ilvIH operon in E. coli.

22 Gene Regulation in Eukaryotes

Microbiology -- Genetic Co de/Regulation Lecture Notes
Eukaryotic gene regulation.
Genetics and Cancer
Links to information on several forms of cancer, including breast cancer and ovarian cancer.
Molecular Cytogenetics (FISH)
A detailed discussion of the technique of fluorescence in situ hybridization.
The Tumor Gene Database
A database that contains information about genes which are targets for cancer-causing mutations; proto-oncogenes and tumor supressor genes.

23 The Genetic Control of Animal Development

Animal Geneticists Discussion Group Home Page
A mailing list that discusses Mendelian and population genetics as it r elates to the livestock industry.
Animal Geneticists Discussion Group Home Page
A mailing list that discusses molecular genetics as it relates to the livestock industry.
6WCGALP
Information on the 6th World Congress on Genetics Applied to Livestock Production.
CGIL WWW Home Page
Home Page for the Centre for the Genetic Improvement of Livestock.

24 The Genetic Control of the Vertebrate Immune System

The McCaig Center for Joint Injury and Arthritis Research
Description of research on epitope mapping of possible autoantigens.
Human Genome
Mapping of mouse and human immune system genes.
The Immune System
Overiview of the vertebrate immune system.
The Genetics of Immunity
Developmental meachanisms of immune diversity.
Department of Immunotechnology , Lund University
Research areas and applications of molecular biology to immune cells and molecules.
How Lymphocytes Produce Antibody
Animated and illu strated description of the role of lymphocytes in the immune response.
The Cytotoxic T Lymphocyte
A QuickTime movie of a killer T cell destroying a virus-infected cell.
Human Immunodeficiency Virus (HIV) Infection
An animated presentation of how the HIV virus infects human immune cells.
Anatomy of a Splinter
An animated presentation of how the immune system responds to a splinter pierces the skin.

25 Complex Inheritance Patterns

Complex Traits
Polygenic traits and heritablity factors.
children with DIABETES
LInks to information, surveys, and support groups for people with diabetes and their families.
DIABETES GENES
Two recently discovered genes that are linked to early-onset diabetes.
Mutant Gene Predicts Heart Disease
A gene recently found to contribute to one form of heart disease.
MORE GENETIC PIECES IN THE OBESITY PUZZLE
How some genes influence obesity.

26 The Genetic Control of Behavior

Canine OCD
The genetic basis of obsessive compulsive disorder (OCD) in dogs.
Mate Selection and Offspring Viability in fr uit flies
A paper on the evolution of mating behavior inDrosphila.
PKU (Phenylketonuria)
Overview of PKU: causes, detection, a nd treatment.
The Genetic Basis of Neurological Disorders
An exercise that introduces the genetic basis of some behavioral disorders to elementary or high school students.
FlyBase Gene Report - period gene
Links to several sources regarding a gene in Drosophila that influences periodic behavior.

27 The Basic Principles of Population Genetics

Bio3501 Jan 22 Notes
An overview of evolution and an introduction to population genetics.
Natural Selection
A discussion of natural selection, with links to sexual selection, kinship selection, genetic drift and microevolution.
Evolution of Modularity
A paper discussing the definition of homologous structures.

28 Genetics and Speciation

Bio3501 Feb 19 Notes
The importance of natural selection in the evolution of po pulations.
Speciation in Oceanic Islands
A report on the speciation of the genus Crepidiastrum on Hahajima Island, Japan.