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CHAPTER   17   DNA Replication
 
1.
A cluster of CG sequences that often marks the beginning of a gene in a mammalian genome is a/an ________.

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2.
A single-strand break in a double-stranded nucleic acid is a/an ________.

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3.
________ is a topological state of DNA in which the helix is underwound or overwound so that the molecule tends to coil up on itself.

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4.
________ is the disk-shaped complex of a histone octamer and DNA that represents the fundamental unit of DNA organization in eukaryotes.

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5.
________ are the short segments of DNA formed in the discontinuous lagging strand synthesis of DNA.

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6.
In addition to a polymerase active site that synthesizes a new polynucleotide chain, many polymerases contain an additional active site that acts to ________ the polymerase.

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7.
________ is the transcriptionally active, relatively uncondensed chromatin in a eukaryotic cell.

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8.
A heritable variation in the level of expression of a gene according to its parental origin is called ________.

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9.
An oligonucleotide that base-pairs with a template polynucleotide strand and is extended through template-directed polymerization is a/an ________.

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10.
During DNA ________, the parental polynucleotide strands separate so that each can direct the synthesis of a complementary daughter strand resulting in two complete DNA double helices.

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11.
________ is a property of a motor protein or other enzyme that undergoes many reaction cycles before dissociating from its track or substrate.

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12.
Reverse transcriptase is a DNA polymerase that uses ________ as its template.

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13.
A model for DNA replication in which DNA polymerase and associated proteins remain stationary while the DNA template is spooled through them is the ________.

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14.
The ________ is the DNA strand that is synthesized as a series of discontinuous fragments that are later joined.

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15.
A highly condensed, nonexpressed eukaryotic DNA is ________.

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16.
________ is the progressive movement of a single-strand break in DNA through the actions of an exonuclease that removes residues followed by a polymerase that replaces them.

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17.
Replication fork is the point in a replicating DNA molecule where the two ________ strands separate in order to serve as templates for the synthesis of new strands.

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18.
The DNA strand that is synthesized continuously during DNA replication is the ________.

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19.
Discontinuous synthesis is a mechanism whereby the ________ of DNA is synthesized as a series of fragments that are later joined.

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20.
The mechanism of DNA duplication in which each new molecule contains one strand from the parent molecule and one newly synthesized strand is ________.

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