|
Home Page
|
|
Table of Contents
|
|
Sample Chapter
|
|
Figures
|
|
Icon Clip Art
|
|
Tables
|
|
Review Questions
|
|
Glossary
|
|
Internet Links
|
|
Exam Copy Request
|
|
WebCT
|
|
Contact Us For updates on Wiley publications of interest Sign our Guestbook |
|
Immunology A Short Course, Fourth Edition
Eli Benjamini, Richard Coico, and Geoffrey Sunshine Paper • February 2000 • 500 pp. • 0-471-34890-2 |
|
The earliest stages of B-cell differentiation
A) occur in the embryonic thymus.
B) require the presence of antigen.
C) involve rearrangement of k-chain gene segments.
D) involve rearrangement of surrogate light-chain gene segments.
E) involve rearrangement of heavy-chain gene segments.
Which of the following is expressed on the surface of the mature B lymphocyte?
A) CD40
B) MHC class II molecules
C) CD32
D) IgM and IgD
E) All of the above.
Which of the following statements is
incorrect?
A) Antibodies in a secondary immune response generally have a higher affinity for antigen
than antibodies formed in a primary response.
B) Somatic hypermutation of V region genes may contribute to changes in antibody affinity
observed during secondary responses.
C) Synthesis of antibody in a secondary response occurs predominantly in the blood.
D) Isotype switching occurs in the presence of antigen.
E) Predominantly IgM antibody is produced in the primary response.
Immature B lymphocytes
A) produce only m chains.
B) are progenitors of T as well as B lymphocytes.
C) express both IgM and IgD on their surface.
D) are at a stage of development where contact with antigen may lead to unresponsiveness.
E) must go through the thymus to mature.
Antigen binding to the B-cell receptor
A) transduces a signal through the antigen-binding chains.
B) invariably leads to B-cell activation.
C) transduces a signal through the Iga and Igb molecules.
D) results in macrophage activation.
E) leads to cytokine synthesis, which activates T cells.
Which of the following would
not be found on a memory B cell:
A) Iga and Igb
B) g heavy chains
C) e heavy chains
D) surrogate light chains
E) k light chains
A 19-year-old African-American presents to her primary care physician with an extranodal mass involving the mandible. Biopsy revealed lymphoma cells with the following characteristics: germline TCR genes, surface IgM+, surface IgD+, CD19+. What normal cell component markers are most similar to those expressed by the lymphoma cell?
A)
Pre-B cell
B)
Immature B cell
C)
Mature B cell
D)
Immature T cell
E)
Mature T cell
In B cell development when the heavy chain first rearranges it may be expressed on the cell surface prior to light chain rearrangement. If this occurs, the heavy chain is associated with which of the following on the surface of the cell?
A)
invariant chain
B)
surrogate light chains
C)
CLIP
D)
b-2 microglobulin
E)
it is expressed by itself
Answers to Review Questions
1. E The earliest events in B-cell differentiation take place in fetal liver and bone marrow in the adult and involve rearrangement of heavy-chain V, D, and J gene segments.
2. E All the molecules are expressed on the surface of the mature B cell.
3. C Antibody synthesis in secondary responses occurs predominantly in lymph nodes, not blood.
4. D In immature B cells, which express only IgM, contact with antigen leads to unresponsiveness rather than activation.
5 C. The molecules Iga and Igb, which are associated with the surface Ig molecule, transduce a signal following antigen binding to surface Ig.
6. D Surrogate light chains are expressed only at the pre-B cell stage of B-cell differentiation.
7. C The surface expression of IgM, IgD, and CD19 is characteristic of mature B cells.
8. C In the early stages of B cell development, the heavy chain is first expressed on the cell surface in association with the non-rearranged molecules VpreB and l5, known as the surrogate light chains.
Home Page | Table of Contents | Sample Chapter | Figures | Tables | Review Questions | Glossary | Internet Links | Exam Copy Request | WebCT
This Web site Copyright © 2000 John Wiley & Sons, Inc. All rights reserved.