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Encyclopedia of Controlled Drug Delivery (2-Volume Set)
Editor: Edith Mathiowitz
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ISBN: 0-471-14828-8 |
A
Alcoholism and drug dependence, drug delivery to treat
B
Bioadhesive Drug delivery systems
Biodegradable Polymers: Poly(phosphoester)s
Biodegradable Polymers: Polyanhydrides
Biodegradable Polymers: Polyesters
Blood Substitutes: A Review of Clinical Trials
C
Calcification, drug delivery to prevent
Cancer, drug delivery to treat - local & systemic
Cancer, Drug Delivery to Treat - Prodrugs
Cardiovascular Drug Delivery Systems
Carrier-mediated transport, oral drug delivery
Central Nervous System, Drug Delivery to treat
Characterization of Delivery Systems, Differential Scanning Calorimetry
Characterization of delivery systems, Gel permeation chromatography
Characterization of delivery systems, Magnetic Resonance Techniques
Characterization of delivery systems, Microscopy
Characterization of delivery systems, Particle Sizing Techniques
Characterization of delivery systems, Surface analysis and controlled release systems
Characterization of Delivery Systems, XPS, SIMS and AFM Analysis
Characterization of Delivery Systems, X-Ray Powder Diffraction
Characterization of delivery systems,Spectroscopy
Chemical Approaches to drug delivery
Coatings
D
Diagnostic Use of microspheres
E
Economic Aspects of Controlled Drug Delivery
F
Fabrication of Controlled-Delivery Devices
Fertility Control
Food and Drug Administration Requirements for Controlled Release Products
H
Hydrogels
I
Immunoisolated Cell Therapy
In vitro-In vivo correlation
Infectious Disease, Drug Delivery to Treat
Intelligent Drug Delivery systems
L
Liposomes
M
Microencapsulation
Microencapsulation for Gene Delivery
Mucosal drug delivery, buccal
Mucosal Drug Delivery, Intravitreal
Mucosal Drug Delivery, Nasal
Mucosal Drug Delivery, occular
Mucosal Drug Delivery, Vaginal Drug Delivery and Treatment Modalities
N
Nanoparticles
Non-degradable polymers for drug delivery
O
Oligonucleotide delivery
Oral Drug Delivery, Small Intestine & Colon
Oral Drug Delivery, Traditional
P
Parenteral Drug Delivery Systems
Patents and Other Intellectual Property Rights in Drug Delivery
Pendent Drugs, release from polymers
Peptide and Protein Drug Delivery
Pharmacokinetics
Poly (Ortho Esters)
Polymeric Systems for Gene Delivery, Chitosan and PINC Systems
Protein Therapeutics for Skeletal Tissue Repair
Pumps (osmotic)-Intro
Pumps/ Osmotic - ALZET® system
Pumps/ Osmotic-VITS Veterinary Implant
Pumps/Osmotic - DUROS™ osmotic implant for humans
Pumps/Osmotic - Ruminal osmotic bolus
R
Release Kinetics, Data Interpretation
Respiratory System Delivery
S
Synthetic Vascular Grafts and Controlled-Release Technology
T
Tissue-Implant Interface,Biological Resp. to Artificial Materials w/ Surface-Immobilized small peptides
Transdermal Drug Delivery, Electrical
Transdermal Drug Delivery, Passive
V
Vaccine Delivery
Veterinary Applications
The two-volume Encyclopedia of Controlled Drug Delivery will provide extensive, yet easily accessible, A-Z coverage of state-of-the-art topics in drug delivery systems. The encyclopedia can be used by research departments in industry, research institutes, universities, libraries, and consultants. The readers may range from undergraduate and graduate students to professional engineers, biologists, chemists, and medical researchers. In addition, research managers, as well as business venturers, will find this encyclopedia a very useful source of information. Scientists unfamiliar with the field of drug delivery will find a good introduction to the field, while experts will find the book to be a good, current source of information. The contents of these two volumes provide coverage of many aspects of drug delivery systems, including:
- The history and development of the field from 1975 to date
- Advantages and disadvantages of controlled release technology as compared to conventional delivery systems (pharmaceutical as well as veterinary applications)
- Detailed descriptions of the various systems for achieving controlled drug release, including nonerodible reservoir and matrix devices, bioerodible polymers, pendent drug substitutes, and osmotic pumps
- Pharmaceutical applications of drug delivery systems, approaches to achieve zerorelease kinetics, development of pulsatile delivery systems including approaches to develop selfregulated systems by using responsive hydrogels or encapsulated live cells
- Stabilization and release characterization of proteins
- Characterization of specific delivery systems such as oral, nasal, ocular, and other routes of administration
- Methods to fabricate controlled delivery systems, including microencapsulation, liposome preparation, film casting, and membrane formation
- Factors affecting regulatory considerations
- Economic aspects of controlled drug delivery devices
- Patents and other intellectual property rights in drug delivery
- Oligonucleotides and gene delivery
- Specific topics in polymer technology which are peculiar to drug delivery systems, including polymer synthesis, structure, morphology, amorphous polymers, glassy and rubbery states, polymer networks, and a variety of methods to characterize polymers and drug delivery systems
The encyclopedia can easily be used as an advanced text or reference book for a drug delivery system course. It is written by some of the greatest experts and most diligent educators in the field. These volumes should constitute an important research reference tool, a desktop information resource, and supplementary reading for teaching professionals and their students.
ACKNOWLEDGMENT
The idea to start this two-volume book came from Hannah Ben-Zvi, of John Wiley and Sons, and caught me by surprise. I had been thinking for many years that there was no encyclopedia for the field of drug delivery systems, which has emerged since the 1970s. The encouragement to start this project came from my students. It was with the help of Kathleen Leach (Pekarek), Wendy Webber, and Camilla Santos that this project was born. I am also extremely thankful to the editorial board for the time and effort they contributed to this endeavor. I would like particularly to mention Howard Bernstein, Robert Gurny, and Nicholas Peppas, who contributed above and beyond to the success of this project. I would also like to thank Pierre Galletti, whose untimely death prevented him from seeing the completion of the encyclopedia. Special thanks to Jules Jacob, Jong Yong, Ben Hertzog, Mark Kreitz, Gerardo Carino, Chris Thanos, MaryEllen Sandor, and Don Chickering. I am also grateful to Glenn Collins of John Wiley, who was always there to help and comfort, to Susan Hirsch, who always kept me on track, and perhaps most importantly to the team of authors who put an enormous amount of time into writing this book. To my husband, who helped with graphics, I am eternally grateful for always being patient, even during the days when he hardly saw me.
Edith Mathiowitz
Brown University
Drug delivery systems that can precisely control drug release rates or target drugs to a specific body site, although a relatively recent technology, have had an enormous medical and economic impact. New drug delivery systems impact nearly every branch of medicine and annual sales of these systems are far in excess of 10 billion dollars. However, to intelligently create new delivery systems or to understand how to evaluate existing ones, much knowledge is needed. Dr. Edith Mathiowitz of Brown University has, in this encyclopedia, successfully put together a remarkable amount of information to achieve that goal of knowledge.
The Encyclopedia of Controlled Drug Delivery provides an up-to-date analysis of critical areas in this promising field. New approaches in treating diseases such as alcoholism, cancer, heart disease, and infectious diseases are examined. Delivery of vaccines, contraceptive agents, anticalcification agents, orthopedic agents, and veterinary agents is discussed. Novel polymeric materials including polyanhydrides, chitosan polyesters, polyphosphates, polyphosphazenes, hydrogels, bioadhesive materials, and poly(ortho esters) are evaluated. Extensive characterization approaches including differential scanning calorimetry, gel permeation chromatography, spectroscopy, X-ray photoelectron spectroscopy, X-ray powder diffraction, and surface characterization are explored.
New areas related to drug delivery such as gene therapy, blood substitutes, food ingredients, and tissue engineering are discussed. An analysis of various routes of administration including parenteral, intravitreal, oral, rectal, ocular, nasal, buccal, vaginal, and the central nervous system is provided. Different controlled release designs such as osmotic pumps, pendentchain systems, membrane systems, nanoparticles, and liposomes are examined. Finally, patents, regulatory issues, manufacturing approaches, economics, in vitro-in vivo correlations, pharmacokinetics, release kinetics, assays, diagnostics, and related issues are considered.
This encyclopedia is a very complete compendium of the stateoftheart of this burgeoning field and should be of considerable value for those who wish to enter it.
ROBERT LANGER
Massachusetts Institute of Technology