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CH-Activation for Asymmetric Synthesis

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CH-Activation for Asymmetric Synthesis

Françoise Colobert, Joanna Wencel-Delord

ISBN: 978-3-527-34340-9 September 2019 286 Pages

Description

Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry

Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed.

Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods.

-Covers one of the most rapidly developing fields in organic synthesis and catalysis
-Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds)
-Edited by two leading experts in C-H activation in asymmetric synthesis

CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Asymmetric activation of C(sp3)-H bonds
-C(sp3)-H bond insertion by metal carbenoids and nitrenoids
- Stereoselective C-C Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
- Stereoselective C-N Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
C(sp3)-H activation as stereodiscriminant step
- Enantioselective Intra- and intermolecular couplings
- Substrat-controlled transformation ? diastereoselective functionalization
Stereoselective synthesis implying activation of C(sp2)-H bonds
C-H activation involved in stereodiscriminant step
-Planar chirality
-Stereoselective synthesis implying activation of C(sp2)-H bonds-Control of axial chirality
-Central chirality via Asymmetric C(sp2)-H activation implying Desymmetrization and kinetic resolution
Non-stereoselective C-H activation followed by selective functionalization of metallacyclic intermediate
Diastereoselective Formation of Alkenes through C(sp2)?H Bond Activation