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Chirality in Drug Research


Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Chiral drugs from a historical point of view (J. Gal)

Stereoselective synthesis of chiral drugs (H. Federsel)
Chiral drugs from natural source (F. Petersen)
Biotransformation methods for preparing chiral drugs and drug intermediates (M. Müller, M. Wubbolts)

Resolution of chiral drugs and drug intermediates by crystallisation (K. Saigo)
Resolution of chiral drugs by preparative chromatography (E. Francotte)

Stereoselective chromatographic methods for drug analysis (W. Lindner)
CE-MS for the quantitative analysis of chiral drugs (J. Veuthey)
Spectrosopic methods for chiral drug analysis (N. Harada)
Modeling of chiral drug-receptor interactions (G. Folkers)
"... In general, the book has been welledited and produced and contains a useful subject index."

"...As appropriately stressed throughout the book, the several issues associated with chirality have emerged as major factors in drug design and development. This book is a timely and well written resource."
Journal of Medicinal Chemistry, 06/2007

"...Overall this is a useful book for process chemists working with chiral compounds in industry and the chapters highlighted in this review are recommended reading."
Organic Process Research and Development Journal, 08/2007