Provides, in one handbook, comprehensive coverage of one of the hottest topics in stereoselective chemistry
Written by leading international authors in the field, this book introduces readers to C-H activation in asymmetric synthesis along with all of its facets. It presents stereoselective C-H functionalization with a broad coverage, from outer-sphere to inner-sphere C-H bond activation, and from the control of olefin geometry to the induction of point, planar and axial chirality. Moreover, methods wherein asymmetry is introduced either during the C-H activation or in a different elementary step are discussed.
Presented in two parts?asymmetric activation of C(sp3)-H bonds and stereoselective synthesis implying activation of C(sp2)-H bonds?CH-Activation for Asymmetric Synthesis showcases the diversity of stereogenic elements, which can now be constructed by C-H activation methods. Chapters in Part 1 cover: C(sp3)-H bond insertion by metal carbenoids and nitrenoids; stereoselective C-C bond and C-N bond forming reactions through C(sp3)?H bond insertion of metal nitrenoids; enantioselective intra- and intermolecular couplings; and more. Part 2 looks at: C-H activation involved in stereodiscriminant step; planar chirality; diastereoselective formation of alkenes through C(sp2)?H bond activation; amongst other methods.
-Covers one of the most rapidly developing fields in organic synthesis and catalysis
-Clearly structured in two parts (activation of sp3- and activation of sp2-H bonds)
-Edited by two leading experts in C-H activation in asymmetric synthesis
CH-Activation for Asymmetric Synthesis will be of high interest to chemists in academia, as well as those in the pharmaceutical and agrochemical industry.
Table of contents
Asymmetric activation of C(sp3)-H bonds
-C(sp3)-H bond insertion by metal carbenoids and nitrenoids
- Stereoselective C-C Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
- Stereoselective C-N Bond Forming Reactions Through C(sp3)?H Bond Insertion of Metal Nitrenoids
C(sp3)-H activation as stereodiscriminant step
- Enantioselective Intra- and intermolecular couplings
- Substrat-controlled transformation ? diastereoselective functionalization
Stereoselective synthesis implying activation of C(sp2)-H bonds
C-H activation involved in stereodiscriminant step
-Stereoselective synthesis implying activation of C(sp2)-H bonds-Control of axial chirality
-Central chirality via Asymmetric C(sp2)-H activation implying Desymmetrization and kinetic resolution
Non-stereoselective C-H activation followed by selective functionalization of metallacyclic intermediate
Diastereoselective Formation of Alkenes through C(sp2)?H Bond Activation