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Pain in Osteoarthritis



Pain in Osteoarthritis

David T. Felson, Hans-Georg Schaible

ISBN: 978-0-470-93055-7 August 2010 Wiley-Blackwell 320 Pages

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An authoritative investigation of the sources and treatment of osteoarthritic joint pain

Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on:

  • The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more
  • Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more
  • Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation

Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.





1. Spinal Mechanisms Contributing to Joint Pain (Hans-Georg Schaible).

2. Activation of Sensory Neurons in the Arthritic Joint (Blair D. Grubb).

3. Changes in the Neural Substrate of Nociception in a Rat Derangement Model of Osteoarthritis (James L. Henry).

4. Inflammatory Mediators and Nociception in Osteoarthritis (Bruce L. Kidd, Jason J. McDougall, and Julia J. Inglis).

5. Phantoms in Rheumatology (Candida S. McCabe, Richard C. Haigh, Nicholas G. Shenker, Jenny Lewis, and David R. Blake).

6. Mechanisms That Generate and Maintain Bone Cancer Pain (Juan Miguel Jimenez-Andrade, Monica Herrera, and Patrick W. Mantyh).

7. Symmetry, T-Cells, and Neurogenic Arthritis (Nicholas G. Shenker, David R. Blake, Candida S. McCabe, Richard C. Haigh, and Paul I. Mapp).


8. Joint Mechanics in Osteoarthritis (Walter Herzog, Douglas Bourne, and Aliaa Rehan Youssef).

9. Neuromuscular Aspects of Osteoarthritis (Kenneth D. Brandt).

10. Pressure-Driven Intravasation of Osseous Fat in the Pathogenesis of Osteoarthritic Pain (Peer A. Simkin).

11. Structural Correlates of Osteoarthritis Pain: Lessons From Magnetic Resonance Imaging (Philip G. Conaghan).

12. Evidence of Sensitization to pain in Human Osteoarthritis (Gunnar Ordeberg).

13. Current Perspectives on the Clinical Presentation of Joint Pain in Human Osteoarthritis (Paul Creamer).


14. General Approach to treating Osteoarthritic Pain: Targeting Biomechanics Inflammation and Nociception (David T. Felson).

15. Neurobiological Mechanisms of Osteoarthritic Pain and Analgesic treatment (Tuhina Neogi and Joachim Scholz).

16. Exercise, Taping, and Bracing as Treatments for Knee Osteoarthritis Pain (Kim Louise Bennell, Michael Anthony Hunt, and Rana Shane Hinman).

17. Treating Inflammation to Relieve Osteoarthritic Pain (David T. Felson).