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Clinical Applications of TGF-Beta



Clinical Applications of TGF-Beta

Gregory R. Bock (Editor), Joan Marsh (Editor)

ISBN: 978-0-470-51407-8 April 2008 264 Pages



TGF-beta, originally identified as a transforming growth factor with similar properties, is now known to exist as a family of factors with similar properties. These factors promote cell proliferation in some tissue types or conditions and induce cell differentiation in others. Features the latest information on the TGF-beta family and its receptors. Describes correlations between TGF-beta and certain cancers, including glioblastomas. Also contains reports of preliminary investigations of clinical applications for TGF-beta in many diseases, including leukemia and its use to accelerate wound healing.
Partial table of contents:

Multiple Forms of TGF-β: Distinct Promoters and Differential Expression (A. Roberts, et al.).

Mechanisms in TGF-β Action (J. Massagué, et al.).

Regulation of Epithelial Proliferation by TGF-β (H. Moses, et al.).

Latent Forms of TGF-β: Molecular Structure and Mechanisms of Action (K. Miyazono & C. Heldin).

TGF-β: A Possible Autocrine Immune Regulator (C. Lucas, et al.).

TGF-β and Wound Healing (E. Amento & L. Beck).

The Effects of TGF-β on Bone (G. Mundy).

Effects of TGF-βs in the Liver: Cell Proliferation and Fibrogenesis (N. Fausto, et al.).

Role of TGF-β1 in Experimental Glomerulonephritis (W. Border, et al.).

In Vivo and in Vitro Effects of TGF-β1 on Normal and Neoplastic Hemopoiesis (F. Ruscetti, et al.).

Expression of TGF-β2 in Human Glioblastoma: A Role in Resistance to Immune Rejection?

(A. Fontana, et al.).

Index of Contributors.

Subject Index.